ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate

ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate Structure
CAS No.
4450-98-0
Chemical Name:
ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate
Synonyms
1-Ebpc;CP-10668;Nsc 229530;Aldose Reductase,inhibit,EBPC,Inhibitor;1-Benzyl-4-bydroxy-5-oxo-3-pyrroline-3-carboxylic Acid Ethyl Ester;1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester;2,5-Dihydro-4-hydroxy-5-oxo-1-(phenylMethyl)-1H-pyrrole-3-carboxylic Acid Ethyl Ester;1H-Pyrrole-3-carboxylic acid, 2,5-dihydro-4-hydroxy-5-oxo-1-(phenylmethyl)-, ethyl ester
CBNumber:
CB51373216
Molecular Formula:
C14H15NO4
Molecular Weight:
261.27
MOL File:
4450-98-0.mol
Modify Date:
2023/6/8 9:01:56

ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate Properties

Melting point 135-136 °C
Boiling point 479.8±45.0 °C(Predicted)
Density 1.340±0.06 g/cm3(Predicted)
storage temp. room temp
solubility DMSO: ≥10mg/mL
form white powder
pka 4.50±1.00(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H318
Precautionary statements  P280-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22-41
Safety Statements  26
WGK Germany  3
HazardClass  IRRITANT
NFPA 704
0
3 0

ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) PZ0140 EBPC ≥98% (HPLC) 4450-98-0 5MG ₹13184.85 2022-06-14 Buy
Sigma-Aldrich(India) PZ0140 EBPC ≥98% (HPLC) 4450-98-0 25MG ₹51180.6 2022-06-14 Buy
Product number Packaging Price Buy
PZ0140 5MG ₹13184.85 Buy
PZ0140 25MG ₹51180.6 Buy

ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate Chemical Properties,Uses,Production

Description

The human aldose reductase AKR1B1 is considered the rate limiting enzyme of the polyol pathway responsible for the conversion of glucose into sorbitol. It also acts as a highly efficient PGF synthase in response to interleukin-1β. Increased aldose reductase expression has been associated with complications of diabetes and may contribute to reduced efficacy of certain chemotherapeutic drugs. EBPC is a potent, selective inhibitor of aldose reductase with an IC50 value of 47 nM in vitro. Through its regulation of glucose metabolism, EBPC has been used to improve the cytotoxic effects of the anticancer agents doxorubicin and cisplatin in HeLa cervical carcinoma cells. EBPC also inhibits prostaglandin F (PGF) and PGE2 production in human endometrial cells with an EC50 value of 10 μM.

Uses

A highly specific aldose reductase inhibitor that has been shown to enhance HeLa cell sensitivity to chemotherapeutic drugs.

ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate Suppliers

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1-Ebpc 1H-Pyrrole-3-carboxylic acid, 2,5-dihydro-4-hydroxy-5-oxo-1-(phenylmethyl)-, ethyl ester Nsc 229530 1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester 1-Benzyl-4-bydroxy-5-oxo-3-pyrroline-3-carboxylic Acid Ethyl Ester 2,5-Dihydro-4-hydroxy-5-oxo-1-(phenylMethyl)-1H-pyrrole-3-carboxylic Acid Ethyl Ester CP-10668 Aldose Reductase,inhibit,EBPC,Inhibitor 4450-98-0 Aromatics Heterocycles Inhibitors Intermediates & Fine Chemicals Pfizer Compounds Pharmaceuticals