ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate
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- ₹13184.85 - ₹51180.6
- Product name: ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate
- CAS: 4450-98-0
- MF: C14H15NO4
- MW: 261.27
- EINECS:
- MDL Number:MFCD00179167
- Synonyms:1-Ebpc;1H-Pyrrole-3-carboxylic acid, 2,5-dihydro-4-hydroxy-5-oxo-1-(phenylmethyl)-, ethyl ester;Nsc 229530;1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester;1-Benzyl-4-bydroxy-5-oxo-3-pyrroline-3-carboxylic Acid Ethyl Ester;2,5-Dihydro-4-hydroxy-5-oxo-1-(phenylMethyl)-1H-pyrrole-3-carboxylic Acid Ethyl Ester;CP-10668;Aldose Reductase,inhibit,EBPC,Inhibitor
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberPZ0140
- Product descriptionEBPC ≥98% (HPLC)
- Packaging5MG
- Price₹13184.85
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberPZ0140
- Product descriptionEBPC ≥98% (HPLC)
- Packaging25MG
- Price₹51180.6
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PZ0140 | EBPC ≥98% (HPLC) | 5MG | ₹13184.85 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PZ0140 | EBPC ≥98% (HPLC) | 25MG | ₹51180.6 | 2022-06-14 | Buy |
Properties
Melting point :135-136 °C
Boiling point :479.8±45.0 °C(Predicted)
Density :1.340±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO: ≥10mg/mL
form :white powder
pka :4.50±1.00(Predicted)
Boiling point :479.8±45.0 °C(Predicted)
Density :1.340±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO: ≥10mg/mL
form :white powder
pka :4.50±1.00(Predicted)
Safety Information
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| Signal word: | Danger | |||||||||||||||||||||
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Description
The human aldose reductase AKR1B1 is considered the rate limiting enzyme of the polyol pathway responsible for the conversion of glucose into sorbitol. It also acts as a highly efficient PGF2α synthase in response to interleukin-1β. Increased aldose reductase expression has been associated with complications of diabetes and may contribute to reduced efficacy of certain chemotherapeutic drugs. EBPC is a potent, selective inhibitor of aldose reductase with an IC50 value of 47 nM in vitro. Through its regulation of glucose metabolism, EBPC has been used to improve the cytotoxic effects of the anticancer agents doxorubicin and cisplatin in HeLa cervical carcinoma cells. EBPC also inhibits prostaglandin F2α (PGF2α) and PGE2 production in human endometrial cells with an EC50 value of 10 μM.Related product price
- 4450-98-0
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