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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >Pyridine compound >Ethylpyridine >(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride

(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride

(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride Structure
CAS No.
119770-60-4
Chemical Name:
(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride
Synonyms
Des Loratadine methanone;Loratadine Methyl Ketone;Loratadine Impurity 10 HCl;Loratadine Impurity 36 HCl;Loratadine Impurity 39 HCl;Loratadine Methanone Impurity;(3-(3-chlorophenethyl)pyridin-;Desloratadine Methanone Impurity;Desloratadine?Methanone?Impurity?HCl;(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridiny...
CBNumber:
CB51503925
Molecular Formula:
C20H24Cl2N2O
Molecular Weight:
379.32
MOL File:
119770-60-4.mol
Modify Date:
2024/1/8 17:20:55
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(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride Properties

Melting point 183-185 °C

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS05,GHS09
Signal word  Warning
Hazard statements  H400-H318-H410-H302
Precautionary statements  P264-P270-P301+P312-P330-P501-P273-P391-P501-P273-P391-P501-P280-P305+P351+P338-P310

(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride Chemical Properties,Uses,Production

Uses

(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride is an important fine chemical, Desloratadine methanone impurity, which can be used in organic synthetic materials or chemical research.

Synthesis

(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride is prepared by the reaction of 4-chloro-1-methylpiperidine and 3-(3-chlorophenethyl)picolinonitrile. The specific synthesis steps are as follows:
Add magnesium (3.6g) and a small amount of iodine into the reaction flask under nitrogen protection,Add re-distilled THF (20ml), 1,2-dibromoethane (1ml), 4-chloro-N-methylpiperidine (1ml), and stir at 75°C; after the liquid surface of the system is foamed, add 4- Chloro-N-methylpiperidine (20.4ml) was dissolved in THF (240ml) and slowly added dropwise. After the dropwise addition, it was reacted for 1h and cooled to room temperature for later use. Compound V (26.0g, 107mmol) was dissolved in THF (250ml) under nitrogen protection;Add the prepared Grignard reagent dropwise to the reaction flask at room temperature to control the temperature of the system; after the dropwise addition, control the temperature of the system at 40-50°C and continue the reaction for 1 hour. After the reaction is completed, adjust the pH of the reaction solution to below 2 with a 2mol/L HCl solution, and continue the reaction at room temperature for 1 hour; after the reaction is completed, THF is distilled off under reduced pressure, and then the pH value of the solution is adjusted with a 50% NaOH solution. Adjust to 3-4, crystallize in an ice-water bath, filter and wash, and dry the solid to obtain a pale yellow powder ((1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride, 33.8 g, 83.3%).
(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride synthesis

(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride Suppliers

Global( 68)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
VASUDHA PHARMA CHEM LIMITED +91-91-4044763666 +91-9396659284 Telangana, India 102 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49392 58 Inquiry
ANHUI WITOP BIOTECH CO., LTD +8615255079626 China 23555 58 Inquiry
Shaanxi Dideu Medichem Co. Ltd +86-029-89586680 +86-18192503167 China 8444 58 Inquiry
sgtlifesciences pvt ltd +8617013299288 China 12382 58 Inquiry
Hefei TNJ Chemical Industry Co.,Ltd. +86-0551-65418684 +8618949823763 China 25363 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43348 58 Inquiry
Supplier Advantage
VASUDHA PHARMA CHEM LIMITED 58
SynZeal Research Pvt Ltd 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Pharma Affiliates 58
CONIER CHEM AND PHARMA LIMITED 58
ANHUI WITOP BIOTECH CO., LTD 58
Shaanxi Dideu Medichem Co. Ltd 58
sgtlifesciences pvt ltd 58
Hefei TNJ Chemical Industry Co.,Ltd. 58
LEAPCHEM CO., LTD. 58

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(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride [3-[2-(3-Chlorophenyl)ethyl]-2-pyridinyl](1-methyl-4-piperidinyl)methanone hydrochloride (3-(3-Chlorophenethyl)pyridin-2-yl)(1-methyl-piperidin-4-yl)methanone hydrochloride Loratadine Methanone Impurity [3-[2-(3-chlorophenyl)ethyl]pyridin-2-yl]-(1-methylpiperidin-4-yl)methanone:hydrochloride Loratadine Impurity 10 HCl Desloratadine Methanone Impurity (3-(3-chlorophenethyl)pyridin- Loratadine Impurity ((1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone) {3-[2-(3-Chlorophenyl)ethyl]pyridine-2-yl}-(1-methyl?piperidine-4-yl) (Methonal HCL) Des Loratadine methanone Desloratadine Impurity 3/Desloratadine Methanone Impurity HCl/Desloratadine Ketone Impurity HCl Loratadine Methyl Ketone (1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride ISO 9001：2015 REACH Desloratadine Methanone Impurity/ Desloratadine Ketone Impurity (Loratadine Methanone Impurity) Loratadine Methanone Impurity (Desloratadine Methanone Impurity/ Desloratadine Ketone Impurity) (1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridiny... Loratadine Impurity 36 HCl Desloratadine?Methanone?Impurity?HCl (1-methyl-4-piperidinyl) [3- [2- (3-chlorophenyl) ethyl] pyridin-2-yl] ketone hydrochloride Loratadine Impurity 39 HCl {3-[2-(3-chlorophenyl)ethyl]pyridin-2-yl}(4- methylcyclohexyl)methanone 119770-60-4 C20H24Cl2N2O