(R)-SLV 319

(R)-SLV 319 Structure
CAS No.
656827-86-0
Chemical Name:
(R)-SLV 319
Synonyms
(R)-SLV 319;SLV 319, (R)-(+)-;(4R)-5-(4-chlorophenyl)-N-(4-chlorophenyl)sulfonyl-N'-methyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide;4-chloro-N-{[3-(4-chloro-phenyl)-4-phenyl-4,5-dihydro-pyrazol-1-yl]-methylamino-methylene}-benzenesulfonamide;1H-Pyrazole-1-carboximidamide, 3-(4-chlorophenyl)-N-[(4-chlorophenyl)sulfonyl]-4,5-dihydro-N'-methyl-4-phenyl-, (4R)-
CBNumber:
CB52453032
Molecular Formula:
C23H20Cl2N4O2S
Molecular Weight:
487.4
MOL File:
656827-86-0.mol
Modify Date:
2023/5/21 10:59:17

(R)-SLV 319 Properties

Boiling point 623.2±65.0 °C(Predicted)
Density 1.38±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
form crystalline solid
pka 11?+-.0.60(Predicted)

(R)-SLV 319 Chemical Properties,Uses,Production

Description

Central cannabinoid (CB1) receptor antagonists may have potential in the treatment of a number of diseases such as neuroinflammatory disorders, cognitive disorders, septic shock, obesity, psychosis, addiction, and gastrointestinal disorders. (R)-SLV 319 is the inactive enantiomer of SLV 319 with 100-fold less affinity for the CB1 receptor. SLV 319 is a potent and selective CB1 receptor antagonist with Ki values of 7.8 and 7,943 nM for CB1 and peripheral cannabinoid (CB2) receptors, respectively. SLV 319 is less lipophilic (log P = 5.1) and therefore more water soluble than other known CB1 receptor ligands.

(R)-SLV 319 Preparation Products And Raw materials

Raw materials

Preparation Products

656827-86-0((R)-SLV 319)Related Search:

(R)-SLV 319 (4R)-5-(4-chlorophenyl)-N-(4-chlorophenyl)sulfonyl-N'-methyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide 4-chloro-N-{[3-(4-chloro-phenyl)-4-phenyl-4,5-dihydro-pyrazol-1-yl]-methylamino-methylene}-benzenesulfonamide 1H-Pyrazole-1-carboximidamide, 3-(4-chlorophenyl)-N-[(4-chlorophenyl)sulfonyl]-4,5-dihydro-N'-methyl-4-phenyl-, (4R)- SLV 319, (R)-(+)- 656827-86-0