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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Mitogen-activated protein kinase (MAPK) >MEK inhibitor >Refametinib

Refametinib

Refametinib Structure
CAS No.
923032-37-5
Chemical Name:
Refametinib
Synonyms
CS-2434;RDEA119;BAY-869766;RefaMetinib;BAY 8697661;RDEA119 USP/EP/BP;REFAMETINIB(RDEA119);RDEA-119 (BAY-869766);Acrylamide Impurity 13;BAY 869766; BAY 86-9766
CBNumber:
CB52561494
Molecular Formula:
C19H20F3IN2O5S
Molecular Weight:
572.34
MOL File:
923032-37-5.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:11
Request For Quotation

Refametinib Properties

Boiling point 566.9±60.0 °C(Predicted)
Density 1.82±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility insoluble in H2O; ≥151.8 mg/mL in DMSO; ≥90.2 mg/mL in EtOH
form Powder
pka 15.54±0.20(Predicted)
color White to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H372-H361
Precautionary statements  P201-P202-P281-P308+P313-P405-P501-P260-P264-P270-P314-P501
HS Code  2935909099

Refametinib Chemical Properties,Uses,Production

Description

Lorlatinib (PF-06463922, Pfizer Oncology, Groton, CT, USA) is an oral TKI that targets both ALK and ROS1 with high affinity and good CNS penetration [91].

Uses

Refametinib (RDEA119, Bay 86-9766) is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2. Potent MEK inhibitor.

Clinical Use

Lorlatinib is the sole third-generation ALK inhibitor at this time; it is approved for ALK-positive NSCLC patients who progressed on at least two ALK inhibitors with one being crizotinib or who progressed on alectinib or ceritinib if either is used in the frontline setting.

target

MEK1

Refametinib Preparation Products And Raw materials

Raw materials

Preparation Products

Refametinib Suppliers

Global( 106)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32835 60 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 23499 58 Inquiry
Baoji Guokang Bio-Technology Co., Ltd. 0917-3909592 13892490616 China 9316 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Hebei Fengjia New Material Co., Ltd +86-0311-87836622 +86-17333973358 China 8054 58 Inquiry
Nantong HI-FUTURE Biology Co., Ltd. +undefined18051384581 China 3136 58 Inquiry
Supplier Advantage
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
SynZeal Research Pvt Ltd 58
ATK CHEMICAL COMPANY LIMITED 60
Dideu Industries Group Limited 58
Baoji Guokang Bio-Technology Co., Ltd. 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
Hebei Fengjia New Material Co., Ltd 58
Nantong HI-FUTURE Biology Co., Ltd. 58

Refametinib Spectrum

RDEA119(923032-37-5)1HNMR

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RDEA119 BAY-869766 RefaMetinib RDEA-119 (BAY-869766) BAY 8697661 RefaMetinib/BAY 8697661 N-[3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]cyclopropanesulfonamide (S)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide REFAMETINIB(RDEA119) CS-2434 BAY 869766; BAY 86-9766 Refametinib (BAY86-9766) N-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)-6-methoxyphenyl]-1-[(2s)-2,3-dihydroxypropyl]cyclopropane-1-sulfonamide BAY 869766;BAY 86-97661;RDEA119 Cyclopropanesulfonamide, N-[3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]- RDEA119 USP/EP/BP Refametinib S enantiomer Acrylamide Impurity 13 923032-37-5 C19H20F3IN2O5S Inhibitors