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MK-4827 (tosylate)

CAS No.: 1038915-73-9

Chemical Name:: MK-4827 (tosylate)

Synonyms: Niraparib Tosylate;Niraparib TOS;Niraparib TsOH;MK-4827 (tosylate);Niraparib Tosilate;Niraparib(MK-4827) tosylate;MK-4827(Niraparib) tosylate;niraparib p-toluenesulfonate;MK-4827, Niraparib TsOH salt;Niraparib Tosylate (MK-4827)

CBNumber:: CB52682012

Molecular Formula:: C26H28N4O4S

Molecular Weight:: 492.58992

MOL File:: 1038915-73-9.mol

Modify Date:: 2024/5/18 8:51:57

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MK-4827 (tosylate) Properties

Melting point	>142oC (dec.)
storage temp.	-20°C Freezer
solubility	Methanol (Slightly)
form	Solid
color	Off-White to Pale Yellow
InChIKey	LCPFHXWLJMNKNC-XOIICWPPNA-N
SMILES	S(C1C=CC(C)=CC=1)(O)(=O)=O.C(C1=CC=CC2=CN(C3C=CC([C@H]4CNCCC4)=CC=3)N=C12)(=O)N \|&1:23,r\|

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

MK-4827 (tosylate) Chemical Properties,Uses,Production

Description

Niraparib tosylate (MK-4827 tosylate) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with an IC50 of 3.8 and 2.1 nM, respectively; with significant activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-fold selective against PARP3, V-PARP, and Tank1. Niraparib tosylate leads to inhibition of repair of DNA damage, activates apoptosis, and shows anti-tumor activity.

Uses

Niraparib is a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.

in vitro

In a whole-cell assay, Niraparib (MK-4827) tosylate hydrate inhibits PARP activity with EC50=4 nM and EC90=45 nM. Niraparib tosylate hydrate inhibits the proliferation of cancer cells with mutant BRCA-1 and BRCA-2 with CC50 in the 10-100 nM range. Niraparib tosylate hydrate displays excellent PARP 1 and 2 inhibition with IC50=3.8 and 2.1 nM, respectively, and in a whole-cell assay. Niraparib tosylate hydrate inhibits PARP within 15 minutes of treatment, reaching about 85% inhibition in the A549 cells at 1 h and about 55% inhibition at 1 h for the H1299 cells.

MK-4827 (tosylate) Preparation Products And Raw materials

Raw materials

Preparation Products

MK-4827 (tosylate) Suppliers

Global( 131)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Dr. Reddy's Laboratories Ltd	+91-4049002900 +91-4049002900	Hyderabad, India	165	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Beijing Hope Pharmaceutical Co., Ltd.	+86-010-67886402 +8613611125266	China	71	58	Inquiry
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	China	10978	58	Inquiry
hebei hongtan Biotechnology Co., Ltd	+86-86-1913198-3935 +8617331935328	China	973	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29826	58	Inquiry
WinWin Chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	China	14279	58	Inquiry

Supplier	Advantage
Dr. Reddy's Laboratories Ltd	58
A.J Chemicals	58
SynZeal Research Pvt Ltd	58
Beijing Hope Pharmaceutical Co., Ltd.	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
hebei hongtan Biotechnology Co., Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
BOC Sciences	58
career henan chemical co	58
WinWin Chemical CO., Limited	58

MK-4827 (tosylate)
To validate that MK-4827 (Niraparib) inhibits PARP in these cell lines, A549 and H1299 cells are treated with 1 μM MK-4827 for....
Aug 26，2019

MK-4827 (tosylate) Spectrum

MK-4827 (tosylate)(1038915-73-9)¹HNMR

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tert-butyl (S)-3-(4-bromophenyl)piperidine-1-carboxylate Niraparib Niraparib tosylate (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide 3-(4-Bromophenyl)piperidine-1-carboxylic acid tert-butyl ester

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Niraparib TsOH niraparib p-toluenesulfonate MK-4827(Niraparib) tosylate MK-4827 (tosylate) (3S)-3-[4-[7-(Aminocarbonyl)-2H-indazol-2-yl]phenyl]piperidine tosylate MK-4827, Niraparib TsOH salt Niraparib(MK-4827) tosylate NIRAPARIB TOSYLATE;MK 4827 TOSYLATE;MK4827 TOSYLATE 2H-Indazole-7-carboxamide,2-[4-[(3S)-3-piperidinyl]phenyl]-,4-methylbenzenesulfonate(1:1) Niraparib TOS MK-4827 (tosylate) ISO 9001：2015 REACH Niraparib Tosylate (MK-4827) Niraparib Tosylate (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide 4-methylbenzenesulfonate Niraparib tosylate monohydrate (S)-2-(4-(piperidin-3-yl)phenyl)-2H-isoindole-4-carboxamide compound with 1-methyl-4-(methylsulfonyl)benzene (1:1) hydrate Niraparib Tosilate 1038915-73-9 C19H20N4OC7H8O3S