Vasicine
- CAS No.
- 6159-55-3
- Chemical Name:
- Vasicine
- Synonyms
- PEGANINE;1,2,3,9-TETRAHYDROPYRROLO[2,1-B]QUINAZOLIN-3-OL;C10733;vasicin;VASICINE;ST012797;TOS-BB-0711;NCI60_030781;(-)-Vasicine;AKOS NCG1-0080
- CBNumber:
- CB5300633
- Molecular Formula:
- C11H12N2O
- Molecular Weight:
- 188.23
- MOL File:
- 6159-55-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/1 18:08:31
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | 1544 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
Vasicine Chemical Properties,Uses,Production
Description
This quinazoline alkaloid was first isolated from the leaves of Adhatoda vasica
Nees by Hooper and subsequently discovered in Peganum harmala under the
name Peganine. The base is optically inactive although Spath and Kesztler have
reported the isolation of the (-)-form from the fresh leaves of A. vasica and
Rosenfeld and Kolesnikow have obtained the same form from the flowers and
stems of Peganum harmala. The salts are readily obtained crystalline, e.g. the
hydrochloride dihydrate, m.p. 208°C (dry); hydriodide dihydrate, m.p. 195°C
(dry); picrate, m.p. 199°C (dec.) and the methiodide, m.p. 187°C.
With AcOH, the alkaloid gives an anomalous acetyl derivative, m.p. 165°C,
subsequently shown to be N-acetylpedadiene. Oxidation with KMn04 gives
4-quinazolone and 4-keto-3 :4-dihydroxyquinazolyl-3-acetic acid, the latter
characterized as the methyl ester, m.p. 152°C.
The crude drug from A. vasica is used in India as a remedy for asthma while
the pure alkaloid acts as a bronchodilator.
Chemical Properties
White needle-like crystals, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from camels.
Biological Activity
Vasicine, isolated from A. vasica, is an alkaloid. It is a natural cholinesterase (cholinesterase) inhibitor, has anticholinesterase activity in preclinical models, and can be used for the development of therapeutic drugs for Alzheimer's disease.
References
Hooper., Pharm. J., 18,841 (1888)
Sen, Ghose.,J. Ind. Chem. Soc., 1,315 (1924)
Ghose., ibid, 4, 1 (1927)
Spath, Nakawitz., Ber., 67,45 (1934)
Spath, Kuffner., ibid, 67, 1494 (1934)
Narang, Ray., Chem. & Ind., 53,698 (1934)
Hanford, Liang, Adams., J. Amer. Chem. Soc., 56, 2780 (1934)
Ghoseetal., ibid, 57,921,951 (1935)
Rosenfeld, Kolesnikov., Ber., 69, 2022 (1936)
Pharmacology:
Chopra., Ind. Med. Gaz., 60, 354 (1925)
Tutaev, Makarova., Trans. Ukraine Inst. Exp. Pharm., 1,32 (1938)
Vasicine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CHEMAZON LABORATORIES | +91 9848551964 | Hyderabad, India | 1320 | 58 | Inquiry |
| Biosyn Research Chemicals | +91 9346022300/+91 9399339999 | Telangana, India | 1340 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21669 | 55 | Inquiry |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | CHINA | 1824 | 58 | Inquiry |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | China | 3777 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24639 | 58 | Inquiry |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | China | 15395 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
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