Chinese english Japanese Germany Korea

ML-180

ML-180 Structure
CAS No.
863588-32-3
Chemical Name:
ML-180
Synonyms
SR1848;ML-180;ML-180 (SR1848);SR1848 >=98% (HPLC);6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-1H-pyrimidine-2，4-dione;6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexyl-1H-pyrimidine-2,4-dione;6-[4-(3-Chlorophenyl)piperazin-1-yl]-3-cyclohexylpyrimidine- ,4(1H,3H)dione;6-(4-(3-chlorophenyl)piperazin-1-yl)-3-cyclohexylpyrimidine-2,4(1H,3H)-dione;2,4(1H,3H)-Pyrimidinedione, 6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-;6-[4-(3-Chlorophenyl)piperazin-1-yl]-3-cyclohexyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
CBNumber:
CB53152684
Molecular Formula:
C20H25ClN4O2
Molecular Weight:
388.89
MOL File:
863588-32-3.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:11
Request For Quotation

ML-180 Properties

Density 1.312±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 10 mg/ml
form A crystalline solid
pka 9.37±0.40(Predicted)
color Off-white to light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
NFPA 704
0
2 0

ML-180 Chemical Properties,Uses,Production

Description

ML-180 is an inverse agonist of liver receptor homolog-1 (LRH-1, IC50 = 3.7 μM) with maximum efficacy of 64% repression. It is inactive at the related steroidogenic factor-1 transcriptional activator. Through LRH-1, ML-180 alters the expression of haptoglobin and serum amyloid proteins A1 and A4, induces the death of estrogen-receptor negative MDA-MB-231 breast cancer cells, and inhibits the steroidogenic acute regulatory promoter (IC50 = 2.05 μM).

ML-180 Preparation Products And Raw materials

Raw materials

Preparation Products

ML-180 Suppliers

Global( 50)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32836 60 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30250 58 Inquiry
Hangzhou MolCore BioPharmatech Co.,Ltd. +86-057181025280; +8617767106207 China 49739 58 Inquiry
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd +86-18341751992 +86-15382112998 China 892 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Wuhan Jingkang en Biomedical Technology Co., Ltd +8613720134139 China 5225 58 Inquiry
ZhengZhou Edward Biology Co.,Ltd 13298105281 13298105281 China 7511 58 Inquiry
Nanjing Tengyi Biotechnology Co., Ltd 025-58851786 17714337195 China 5585 58 Inquiry
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. 025-66061636 18013972705 China 8263 58 Inquiry
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 60
TargetMol Chemicals Inc. 58
Career Henan Chemica Co 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 58
Aladdin Scientific 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 58
ZhengZhou Edward Biology Co.,Ltd 58
Nanjing Tengyi Biotechnology Co., Ltd 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. 58

ML-180 Spectrum

ML-180(863588-32-3)1HNMR

863588-32-3(ML-180)Related Search:

5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one ML-228 ML188 (Racemate) ML 18 ML-098
ML277 ML 204 ML329 ML364 VU0456810
ML188 ML418 [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone ML213 N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
ML-327 PTP1B-IN-2 ML264
chevron_left

1of4

chevron_right
ML-180 SR1848 6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexyl-1H-pyrimidine-2,4-dione 2,4(1H,3H)-Pyrimidinedione, 6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl- 6-(4-(3-chlorophenyl)piperazin-1-yl)-3-cyclohexylpyrimidine-2,4(1H,3H)-dione SR1848 >=98% (HPLC) ML-180 (SR1848) 6-[4-(3-Chlorophenyl)piperazin-1-yl]-3-cyclohexylpyrimidine- ,4(1H,3H)dione 6-[4-(3-Chlorophenyl)piperazin-1-yl]-3-cyclohexyl-1,2,3,4-tetrahydropyrimidine-2,4-dione ML-180,steroidogenic,SR-1848,Inhibitor,ML180,Orphan,factor-1,LRH-1,cancers,nuclear,NR5A2,NR5A1,ML 180,inhibit,homolog,liver,SR 1848,receptor,SF-1 6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-1H-pyrimidine-2，4-dione 863588-32-3