2-Deoxy-D-ribose
- CAS No.
- 533-67-5
- Chemical Name:
- 2-Deoxy-D-ribose
- Synonyms
- Deoxyribose;D-2-DEOXYRIBOSE;THYMINOSE;2-DEOXYRIBOSE;D-erythro-Pentose, 2-deoxy-;(3S,4R)-3,4,5-trihydroxypentanal;desoxyribose;D-deoxyribose;(2R,4S,5R)-5-(hydroxyMethyl)tetrahy-drofuran-2,4-diol;ribodesose
- CBNumber:
- CB5315585
- Molecular Formula:
- C5H10O4
- Molecular Weight:
- 134.13
- MOL File:
- 533-67-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/9 22:15:29
| Melting point | 89-90 °C(lit.) |
|---|---|
| Boiling point | 167.23°C (rough estimate) |
| alpha | -57 º (c=1, H2O, 24hr) |
| Density | 1.0590 (rough estimate) |
| refractive index | -56 ° (C=1, H2O) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated) |
| form | Crystalline Powder |
| pka | 12.61(at 25℃) |
| color | White to slightly yellow |
| optical activity | [α]22/D 59°, c = 1 in H2O |
| Water Solubility | soluble |
| Sensitive | Hygroscopic |
| Merck | 14,2908 |
| BRN | 1721978 |
| Stability | Hygroscopic |
| InChIKey | ASJSAQIRZKANQN-CRCLSJGQSA-N |
| CAS DataBase Reference | 533-67-5(CAS DataBase Reference) |
| NIST Chemistry Reference | D-Erythro-pentose, 2-deoxy-(533-67-5) |
| EPA Substance Registry System | D-erythro-Pentose, 2-deoxy- (533-67-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 24/25-37/39-36-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | SB7230000 | |||||||||
| F | 3-10 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29400000 | |||||||||
| NFPA 704 |
|
2-Deoxy-D-ribose price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D5899 | 2-Deoxy-D-ribose suitable for cell culture, BioReagent | 533-67-5 | 10MG | ₹2165 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 31170 | 2-Deoxy-D-ribose ≥99.0% (TLC) | 533-67-5 | 1G | ₹1818.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D5899 | 2-Deoxy-D-ribose suitable for cell culture, BioReagent | 533-67-5 | 1G | ₹4438.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 31170 | 2-Deoxy-D-ribose ≥99.0% (TLC) | 533-67-5 | 5G | ₹7534.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 31170 | 2-Deoxy-D-ribose ≥99.0% (TLC) | 533-67-5 | 25G | ₹17655.58 | 2022-06-14 | Buy |
2-Deoxy-D-ribose Chemical Properties,Uses,Production
Description
2-deoxy-D-Ribose is a reducing sugar formed as a degradation product during metabolism of thymidine by thymidine phosphorylase. It increases levels of reactive oxygen species (ROS) in HL-60 human leukemia cells when used at a concentration of 15 mM. 2-deoxy-D-Ribose (10 μM) induces tubulogenesis and migration of bovine aortic endothelial (BAE) cells. Topical administration of 2-deoxy-D-ribose increases blood vessel formation and accelerates wound healing in a rat full-thickness cutaneous wound model.
Chemical Properties
White powder
Definition
ChEBI: 2-deoxy-D-ribose is a deoxypentose that is D-ribose in which the hydroxy group at position C-2 is replaced by hydrogen. It has a role as a human metabolite, a Saccharomyces cerevisiae metabolite and a mouse metabolite. It is functionally related to a D-ribose.
Purification Methods
Dissolve 2-deoxy--D-ribose in a little H2O, evaporate to a syrup (in a vacuum), and seed to crystallise. Triturate the crystals with a little EtOAc containing 5% MeOH, decant and dry in vacuum over P2O5. It is best purified via the anilide which separates from a mixture of the ribose (100-125g) in MeOH (100mL) and redistilled aniline (40mL) in a few minutes. After standing for 20hours at room temperature, it is cooled to 0o, filtered, washed with 50% aqueous MeOH and Et2O followed by recrystallisation from ethylene glycol monomethyl ether. The anilide has m 172-173o, [ ] D 25 +46o (equilibrium in pyridine). The anilide (5g), benzaldehyde (5mL) and benzoic acid (0.5g) in H2O (150mL) are shaken mechanically for 2024hours. The aqueous phase is extracted with Et2O (3x), decolourised with a little charcoal and evaporated in a vacuum to a syrup. This is dried over P2O5 in high vacuum. The syrupy sugar weighs 3.1g and crystallises in a few days, but more rapidly on seeding. Triturate it with a little EtOAc containing 5% MeOH, decant and dry it over P2O5. At this stage it has m 78-82o, [ ] D 25 -57o (c 1, H2O final). This is a mixture of and anomers. Pure -anomer is obtained by recrystallisation from EtOAc The -anomer when recrystallised from EtOAc and isoPrOH has m 96-98o, [ ] D 25 -55o (c 0.5, H2O final). [Sowden Biochemical Preparations 5 75 1957.] The mutarotation is as follows: [] D 20.5 +96.3o(0minutes), -76o(33minutes), -56o (24hours) (c 5.8 MeOH). It is moderately hygroscopic and should be kept in a well stoppered bottle. It also crystallises from diethyl ether. [Deriaz et al. J Chem Soc 1879 1949, Beilstein 1 IV 4181, Hauske & Rapoport J Org Chem 4 4 2472 1979.]
2-Deoxy-D-ribose Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Vardhaman P Golechha | 9704422000 | Telangana, India | 294 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Central Drug House(P) Ltd. | 91-11-49404040 | New Delhi, India | 6160 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Vardhaman P Golechha | 58 |
| JSK Chemicals | 58 |
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| CHEMSWORTH | 30 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Triveni chemicals | 58 |
| Central Drug House(P) Ltd. | 58 |
| SynZeal Research Pvt Ltd | 58 |
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