Magnesium stearate
- CAS No.
- 557-04-0
- Chemical Name:
- Magnesium stearate
- Synonyms
- MAGNESIUM OCTADECANOATE;stearatedemagnesium;Magnesium Stearate Bp;C4d-A;Dolomol;Anti-C4d-A;硬脂酸镁生产厂家价格;petracmg20nf;nesium stearate;MAGENSIUM STEARATE
- CBNumber:
- CB5330900
- Molecular Formula:
- C36H70MgO4
- Molecular Weight:
- 591.24
- MOL File:
- 557-04-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/14 18:30:21
| Melting point | 200 °C (lit.) |
|---|---|
| Density | 1.028g/cm3 |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | alcohol: insoluble |
| form | Fine Powder |
| color | White |
| PH | 7 (H2O) (slurry) |
| Odor | wh. soft oily powd., tasteless, odorless |
| Water Solubility | Insoluble |
| Merck | 14,5690 |
| BRN | 3919702 |
| Exposure limits | ACGIH: TWA 10 mg/m3; TWA 3 mg/m3 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | DRJIJXNWSSRTTE-UHFFFAOYSA-M |
| LogP | 8.216 (est) |
| CAS DataBase Reference | 557-04-0(CAS DataBase Reference) |
| EPA Substance Registry System | Magnesium stearate (557-04-0) |
Magnesium stearate price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 415057 | Magnesium stearate technical grade | 557-04-0 | 25G | ₹5607.35 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 415057 | Magnesium stearate technical grade | 557-04-0 | 1KG | ₹7068.73 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 26454 | Magnesium stearate puriss., meets analytical specification of Ph.?Eur., BP, ≥90% stearic and palmitic acid basis, ≥40% stearic acid basis (GC), 4.0-5.0% Mg basis (calc o | 557-04-0 | 1KG | ₹4124.33 | 2022-06-14 | Buy |
| TCI Chemicals (India) | S0238 | Magnesium(II) Stearate | 557-04-0 | 25G | ₹1600 | 2022-05-26 | Buy |
| TCI Chemicals (India) | S0238 | Magnesium(II) Stearate | 557-04-0 | 250G | ₹2600 | 2022-05-26 | Buy |
Magnesium stearate Chemical Properties,Uses,Production
Description
Magnesium stearate, also called octa decanoic acid, magnesium salt, is a white substance, powder which becomes solid at room temperature. It has the chemical formula Mg(C18H35O2)2. It is a salt containing two equivalents of stearate (the anion of stearic acid) and one magnesium cation (Mg2+). Magnesium stearate melts at about 120 °C, is not soluble in water, and is generally considered safe for human consumption at levels below 2500 mg/kg per day.In 1979, the FDA's Subcommittee on GRAS (generally recognized as safe) Substances (SCOGS) reported, "There is no evidence in the available information on ... magnesium stearate ... that demonstrates, or suggests reasonable grounds to suspect, a hazard to the public when they are used at levels that are now current and in the manner now practiced, or which might reasonably be expected in the future.".
Chemical Properties
Magnesium stearate is a very fine, light white, precipitated or milled, impalpable powder of low bulk density, having a faint odor of stearic acid and a characteristic taste. The powder is greasy to the touch and readily adheres to the skin. nonflammable used in baby dusting powder(s) and as tablet lubricant.
Uses
Magnesium Stearate is the magnesium salt of stearic acid which functions as a lubricant, binder, emulsifier, and anticaking agent. it is a white powder that is insoluble in water. it is used as a lubricant or die release in tableting pressed candies and is also used in sugar- less gum and mints.
Preparation
Magnesium stearate is created by the reaction of sodium stearate with magnesium sulfate.
Production Methods
Magnesium stearate is prepared either by the interaction of aqueous solutions of magnesium chloride with sodium stearate or by the interaction of magnesium oxide, hydroxide, or carbonate with stearic acid at elevated temperatures.
Definition
Mg(C18H35O2)2 or with one H2O. Technical grade contains small amounts of the oleate and 7% magnesium oxide, MgO.
General Description
Magnesium stearate (Mg-St) is the magnesium salt of stearic acid. Its anhydrate, dihydrate and trihydrate forms have been prepared. The tabletting of the blends of magnesium stearate and lactose granules has been described. The influence of mixing time on hardness, disintegration time and ejection force on the compressed tablets was examined. Mg-St is widely used lubricant in pharmaceutical industry. It also plays a role in delaying the process of dissolution. Its detection in tablets by laser-induced breakdown spectroscopy has been proposed.
Pharmaceutical Applications
Magnesium stearate is widely used in cosmetics, foods, and pharmaceutical formulations. It is primarily used as a lubricant in capsule and tablet manufacture at concentrations between 0.25% and 5.0% w/w. It is also used in barrier creams.
Safety Profile
Slightly toxic by ingestion. Spontaneously combustible. When heated to decomposition it emits acrid smoke and toxic fumes.
Safety
Magnesium stearate is widely used as a pharmaceutical excipient
and is generally regarded as being nontoxic following oral
administration. However, oral consumption of large quantities
may produce a laxative effect or mucosal irritation.
No toxicity information is available relating to normal routes of
occupational exposure. Limits for heavy metals in magnesium
stearate have been evaluated in terms of magnesium stearate worstcase
daily intake and heavy metal composition.
Toxicity assessments of magnesium stearate in rats have
indicated that it is not irritating to the skin, and is nontoxic when
administered orally or inhaled.
Magnesium stearate has not been shown to be carcinogenic
when implanted into the bladder of mice.
LD50 (rat, inhalation): >2 mg/L
LD50 (rat, oral): >10 g/kg
storage
Magnesium stearate is stable and should be stored in a well-closed container in a cool, dry place.
Incompatibilities
Incompatible with strong acids, alkalis, and iron salts. Avoid mixing with strong oxidizing materials. Magnesium stearate cannot be used in products containing aspirin, some vitamins, and most alkaloidal salts.
Regulatory Status
GRAS listed. Accepted as a food additive in the USA and UK. Included in the FDA Inactive Ingredients Database (oral capsules, powders, and tablets; buccal and vaginal tablets; topical preparapreparations; intravitreal implants and injections). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients. Listed on the US TSCA inventory.
Magnesium stearate Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Indiana ChemPort | +91-91-2652638667 +91-7574886711 | Gujarat, India | 85 | 58 | Inquiry |
| Atul Intermediates | +91-7940399111 +91-9825071644 | Gujarat, India | 24 | 58 | Inquiry |
| Gangotri Inorganic Private Limited | +91-9725738888 +91-9898237777 | Gujarat, India | 33 | 58 | Inquiry |
| Sunkem Industries | +91-9839115521 +91-9839115521 | Gujarat, India | 19 | 58 | Inquiry |
| S.V ENTERPRISES | +919322701159 | Mumbai, India | 150 | 58 | Inquiry |
| Choice Chemicals | +91-9895031268 +91-9895031268 | Kerela, India | 118 | 58 | Inquiry |
| SAANVI CORP | +91-7208939370 +91-7208939370 | Maharashtra, India | 46 | 58 | Inquiry |
| Otto Chemie Pvt Ltd | +91-2222070099 +91-2266382599 | Maharashtra, India | 429 | 58 | Inquiry |
| Kronox Lab Sciences Pvt Ltd | +91-9313231074 +91-9313231074 | Gujarat, India | 240 | 58 | Inquiry |
| MLA Industries | +919336432992 | Uttar Pradesh, India | 20 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Indiana ChemPort | 58 |
| Atul Intermediates | 58 |
| Gangotri Inorganic Private Limited | 58 |
| Sunkem Industries | 58 |
| S.V ENTERPRISES | 58 |
| Choice Chemicals | 58 |
| SAANVI CORP | 58 |
| Otto Chemie Pvt Ltd | 58 |
| Kronox Lab Sciences Pvt Ltd | 58 |
| MLA Industries | 58 |
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