Silymarin
- CAS No.
- 65666-07-1
- Chemical Name:
- Silymarin
- Synonyms
- Silybum marianum;MilkthistleP.E.exsemencardui;ymarin;Legalon;NSC4733;NSC 4733;NSC-4733;Silymarin;SILYBIN(P);Ccris 7096
- CBNumber:
- CB5348848
- Molecular Formula:
- C25H22O10
- Molecular Weight:
- 482.44
- MOL File:
- 65666-07-1.mol
- Modify Date:
- 2024/7/25 20:04:51
| Melting point | 158 °C |
|---|---|
| storage temp. | -20°C |
| solubility | Acetone (Slightly), DMSO (Slightly), Methanol (Very Slightly) |
| form | Solid |
| color | Light Orange to Brown |
| InChI | InChI=1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-18-7-12(3-5-16(18)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3 |
| InChIKey | FDQAOULAVFHKBX-UHFFFAOYSA-N |
| SMILES | C1(C2=CC=C3OC(C4=CC=C(O)C(OC)=C4)C(CO)OC3=C2)OC2=CC(O)=CC(O)=C2C(=O)C1O |
| CAS DataBase Reference | 65666-07-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H373-H361 |
| Precautionary statements | P260-P314-P501-P201-P202-P281-P308+P313-P405-P501 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
Silymarin price More Price(2)
Silymarin Chemical Properties,Uses,Production
Uses
Silymarin a flavonolignan complex extracted from milk thistle, has been shown to provide cytoprotective, antioxidant and hepatoprotective effects. Provides extracts such as (+)-taxifolin as an inhibitor of β-amyloid aggregation.
Indications
Milk thistle (Silybum [Carduus] marianus) is a spiny European plant with white-veined leaves and milky sap, the seed of which is used to treat liver disease.Milk thistle seed extract is used orally in the treatment of alcoholic and other cirrhoses and in Europe intravenously for its hepatoprotective effect in Amanita and other mushroom poisonings. It is grown in this country primarily as a “liver cleanser” and is reputed to protect this organ from a wide array of toxins.Milk thistle seed contains the active principle silymarin, a complex of flavonolignan compounds including silibinin (silybin), silidianin, and silychristin.
General Description
Silymarin is a flavonolignan, obtained from milk thistle (Silybum marianum) plant.
Mechanism of action
Silymarin is thought to protect the liver by preventing the entry of toxins into the hepatocyte and by stimulating nucleolar polymerase A, which, in turn, increases protein synthesis and liver regeneration. Silymarin undergoes enterohepatic circulation, increasing its concentration in hepatocytes. It is also an antioxidant in its own right and is considered to have some cytoprotective effect against carcinogens.
Clinical Use
Alcoholic cirrhosis has been improved (faster return
of liver enzymes to baseline) in at least three trials, although
one multicenter Spanish study failed to
demonstrate any change in the clinical course.There is
no evidence to support the use of milk thistle to increase
alcohol tolerance, although it is certainly being
used for this purpose. The effectiveness of silymarin
for viral hepatitis is not clear, although several trials
demonstrated enough benefit to encourage further
studies.
Intravenous silymarin has been demonstrated to
lower mortality from Amanita mushroom poisonings,
but this formulation is available only in Europe.Animal
studies have demonstrated hepatic protection against
alcohol, acetaminophen, and mushroom toxins and protection
against hepatic fibrosis with bile duct occlusion.
There is also evidence of silybin protecting against cisplatin-
induced nephrotoxicity in rats. It is not yet clear
whether milk thistle extract offers any renal protection
to humans.
Side effects
Milk thistle appears to be remarkably safe, with loose stools due to increased bile solubility and occasional allergic reactions being the common side effects. It has not been evaluated in children or in pregnant women.There are no known serious drug or herb interactions.
Silymarin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Medi Pharma Drug House | +919930911911 | Mumbai, India | 143 | 58 | Inquiry |
| Himpharm | +91-9816648055 +91-9816664455 | Himachal Pradesh, India | 29 | 58 | Inquiry |
| Quality Products Lab Private Limited | 08048250471Ext 345 | Uttar Pradesh, India | 43 | 58 | Inquiry |
| Vital Herbs | 08046067358 | Delhi, India | 36 | 58 | Inquiry |
| Herbo Nutra | +91-8048966502 | Delhi, India | 27 | 58 | Inquiry |
| Phytotech Extracts Private Limited | 08048372076Ext 241 | Karnataka, India | 3 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Xi'an ZB Biotech Co.,Ltd | +8618591943808 | China | 816 | 58 | Inquiry |
| Lewoo Pharmatech(Shanghai)Co.,Ltd | +86-15800805830 +86-15800805830 | China | 184 | 58 | Inquiry |
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Related Qustion
- Q:Is silymarin good for people with high blood pressure or fatty liver disease?
- A:?Positive effects of silymarin supplementation were also reported in humans, namely in patients with hypertension and microalb....
- Apr 9，2024
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