IONOMYCIN
- CAS No.
- 56092-81-0
- Chemical Name:
- IONOMYCIN
- Synonyms
- Ionomycin from Streptomyces conglobatus;EM 94;SQ-23377;IONOMYCIN;SQ 23377, EM 94;Ionomycinefreeacid;IONOMYCIN (SQ23377);IONOMYCIN USP/EP/BP;Ionomycin, Free Base;Ionomycin Free Acid (85%)
- CBNumber:
- CB5380046
- Molecular Formula:
- C41H72O9
- Molecular Weight:
- 709.01
- MOL File:
- 56092-81-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Boiling point | 817.2±65.0 °C(Predicted) |
|---|---|
| Density | 1.072±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | Soluble to 10 mM in Ethanol and to 10 mM in DMSO. |
| form | Waxy solid |
| pka | 4.77±0.10(Predicted) |
| color | Yellow |
| BRN | 3642126 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS02 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H225 | |||||||||
| Precautionary statements | P210-P240-P241-P280a-P303+P361+P353-P501a | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 36-36/37/39-27-26-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NO0650000 | |||||||||
| F | 8-10 | |||||||||
| HazardClass | 3 | |||||||||
| HS Code | 29419090 | |||||||||
| NFPA 704 |
|
IONOMYCIN price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | I9657 | Ionomycin from Streptomyces conglobatus ≥98% (HPLC) | 56092-81-0 | 1MG | ₹20838.13 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | I9657 | Ionomycin from Streptomyces conglobatus ≥98% (HPLC) | 56092-81-0 | 5MG | ₹74454.35 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 407950 | Ionomycin, Free Acid, Streptomyces conglobatus - CAS 56092-81-0 - Calbiochem Ionomycin, Free Acid, Streptomyces conglobatus, CAS 56092-81-0, is a highly specific for divalent cations and more effective than A23187 (Cat. No. 100 | 56092-81-0 | 1MG | ₹17380.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 407950 | Ionomycin, Free Acid, Streptomyces conglobatus - CAS 56092-81-0 - Calbiochem Ionomycin, Free Acid, Streptomyces conglobatus, CAS 56092-81-0, is a highly specific for divalent cations and more effective than A23187 (Cat. No. 100 | 56092-81-0 | 5MG | ₹67380 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 407950 | Ionomycin, Free Acid, Streptomyces conglobatus - CAS 56092-81-0 - Calbiochem Ionomycin, Free Acid, Streptomyces conglobatus, CAS 56092-81-0, is a highly specific for divalent cations and more effective than A23187 (Cat. No. 100 | 56092-81-0 | 10MG | ₹117120.01 | 2022-06-14 | Buy |
IONOMYCIN Chemical Properties,Uses,Production
Chemical Properties
White powder
Uses
Ionomycin was isolated from Streptomyces conglobatus as a potent Gram positive antibiotic . During isolation, it was recognised that ionomycin exhibits a very high affinity and selectivity for calcium ions, suggesting the metabolite acts as a calcium ionophore. More recently, ionomycin has been used in cell biology as a universal calcium ionophore to explore the role of calcium regulation in the cell.
Definition
ChEBI: A very long-chain fatty acid that is docosa-10,16-dienoic acid which is substituted by methyl groups at positions 4, 6, 8, 12, 14, 18 and 20, by hydroxy groups at positions 11, 19 and 21, and by a (2',5-dimethyloctahydro-2,2'-bifuran-5-yl)ethanol group at osition 21. An ionophore produced by Streptomyces conglobatus, it is used in research to raise the intracellular level of Ca2+ and as a research tool to understand Ca2+ transport across biological memb anes.
General Description
Highly specific for divalent cations (Ca2+ > Mg2+ >> Sr2+ = Ba2+). More effective than antibiotic A23187 as a mobile ion carrier for Ca2+. Complexes with Ca2+ between pH 7 and 9.5, causing significant absorption in the UV range; however, in contrast to A23187 (Cat. No. 100105), it is not fluorescent. Useful for studies of Ca2+ transport across biological membranes and measurement of cytoplasmic free Ca2+. Induces apoptotic neuronal degeneration in embryonic cortical neurons. Also induces cell cycle arrest in the G1 interval of mature Burkitt lymphoma cell lines.
Biological Activity
Calcium ionophore; more specific than A23187 (5-(Methylamino)-2-[[2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)-ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid ).
IONOMYCIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | China | 10326 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24330 | 58 | Inquiry |
| BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
| LEAP CHEM CO., LTD. | +86-852-30606658 | China | 24738 | 58 | Inquiry |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | China | 8474 | 58 | Inquiry |
| LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | China | 33350 | 58 | Inquiry |