RHOEADINE
- CAS No.
- 2718-25-4
- Chemical Name:
- RHOEADINE
- Synonyms
- rhoeadin;rheadine;RHOEADINE;Brn 0098745;(+)-Rheadine;Rheadine (8ci);RHODIZONIC ACID Dihydrate(RG);8β-Methoxy-16-methyl-2,3:10,11-bis[methylenebis(oxy)]rheadan;8-beta-methoxy-16-methyl-2,3:10,11-bis(methylenebis(oxy))rheadan;3:10,11-bis(methylenebis(oxy))-8-methoxy-16-methyl-(8-beta)-rheada
- CBNumber:
- CB5435166
- Molecular Formula:
- C21H21NO6
- Molecular Weight:
- 383.4
- MOL File:
- 2718-25-4.mol
- Modify Date:
- 2023/5/25 18:01:13
RHOEADINE Chemical Properties,Uses,Production
Description
This alkaloid was found by Hesse in Papaver rhoeas Linn (red poppy) and its
reputed existence in opium now appears doubtful. The base crystallizes from a
mixture of CHCl3 and Et20 and sublimes at 21 5-225°C/0.02 mm. It has
[α]17.5D + 232° (CHCI 3) or [α]19D + 243° (CHCl3). It behaves as a weak base and
is sparingly soluble in H20, alkaline solutions and most organic solvents. It
dissolves in mineral acids giving an intensely red solution but investigation shows that only a small proportion of the alkaloid is used to produce the colour, the
major part being converted into a colourless, crystalline substance, Rhoeagenine,
a much stronger base, non-volatile, and stable to acids. This base is not isomeric
with the alkaloid as first thought but has the formula C2oH1906N, m.p. 236-8°C; [α]19D + l68° (AcOH).).
Rhoeadine itself contains two methylenedioxy groups, one methoxy group
and an N-methyl group. The salts are not easy to prepare but a crystalline
hydriodide dihydrate is formed by addition of KI to a solution of the alkaloid in
AcOH. The ultraviolet spectrum of the alkaloid shows absorption maxima at 205,
240 and 292 mμ.
Uses
As an isoquinoline alkaloid, Rhoeadine can be used in the therapeutic field particularly for the prevention and the treatment of pathologies implying a central and/or peripheral disorder.
References
Hesse., Annalen, Suppl., 4, 50 (1S65)
Hesse., ibid, 140, 145 (1S66)
Spath., Monatsh., 68,33 (1936)
Awe., Arch. Pharm., 279,116 (1941)
Santavy etat., Collect. Czech. Chem. Commun., 30,335,3479 (1965)
Mass spectrum:
Dolejs, Hanus., Tetrahedron, 23, 2997 (1967)
Stereochemistry:
Shamma et at., Chem. Commun., 212 (1968)
RHOEADINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30250 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| ABCR GmbH & CO. KG | 49 721 95061 0 | Germany | 6846 | 75 | Inquiry |
| Shanghai Sanhao Biological Technology Co., Ltd. | 021-67891653 18202139324 | CHINA | 6411 | 58 | Inquiry |
| cjbscvictory | 13348960310 13348960310 | China | 10000 | 58 | Inquiry |
| SHANGHAI ZZBIO CO., LTD. | 13916577892 19921389125 | China | 12063 | 58 | Inquiry |
| Chengdu Push Bio-Technology Co., Ltd. | 028-85370565-229 18080489829 | China | 9369 | 60 | Inquiry |
| ChromaDex | 949 419 0288 | United States | 2501 | 76 | Inquiry |
| Apin Chemicals Ltd. | +44 1235 832515 | United Kingdom | 6811 | 42 | Inquiry |
2718-25-4(RHOEADINE)Related Search:
1of4
chevron_right