Phenylephrine
- CAS No.
- 59-42-7
- Chemical Name:
- Phenylephrine
- Synonyms
- PHENYLEPHRINE BASE;Phenylephrin;L-PHENYLEPHRINE;(r)-phenylephrine;(-)-Phenylephrine Base;(R)-3-(1-Hydroxy-2-(methylamino)ethyl)phenol;C07441;Mesaton;Mezaton;Mydfrin
- CBNumber:
- CB0438096
- Molecular Formula:
- C9H13NO2
- Molecular Weight:
- 167.21
- MOL File:
- 59-42-7.mol
- Modify Date:
- 2024/7/2 8:54:58
| Melting point | 171°C |
|---|---|
| Boiling point | 295.79°C (rough estimate) |
| Density | 1.1222 (rough estimate) |
| refractive index | -55.5 ° (C=5, 1mol/L HCl) |
| storage temp. | -20°C Freezer, Under inert atmosphere |
| solubility | Slightly soluble in water, sparingly soluble in methanol, slightly soluble in ethanol (96 per cent). It dissolves in dilute mineral acids and in dilute solutions of alkali hydroxides. |
| pka | pKa 8.9 (Uncertain) |
| form | Solid |
| color | White to Off-White |
| CAS DataBase Reference | 59-42-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzenemethanol, 3-hydroxy-«alpha»-[(methylamino)methyl]-, (r)-(59-42-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38-41-37/38 | |||||||||
| Safety Statements | 26-36-45-39 | |||||||||
| RTECS | DO7175000 | |||||||||
| HS Code | 2922.19.7000 | |||||||||
| Toxicity | LD50 oral in rat: 350mg/kg | |||||||||
| NFPA 704 |
|
Phenylephrine price More Price(2)
Phenylephrine Chemical Properties,Uses,Production
Description
This synthetic drug has both chemical and pharmacological similarities to norepinephrine. A characteristic quality of phenylephrine is the distinctly expressed selectivity to α- adrenoreceptors, especially α1-adrenoreceptors. Although phenylephrine increases the contractibility of blood vessels, in practical terms it is not considered a cardiostimulant.
Chemical Properties
White or almost white, crystalline powder.
Uses
L-Phenylephrine is an adrenergic α1A receptor agonist (Ki = 1.4 μM) that demonstrates selectivity against the α1B and α1C receptor subtypes (Kis = 23.9 and 47.8 μM, respectively). By stimulating adrenergic α1 receptors, L-phenylephrine can induce aortic smooth muscle contractions, although reported relative affinity and potency values in rabbit are 5-fold weaker compared to that of L-norepinephrine. This compound is frequently used to precontract smooth muscle in preparations designed to study the properties of various vasodilator agents. Because L-phenylephrine acts on adrenergic α1 receptors in the arterioles of the nasal mucosa to produce constriction, it has been examined clinically as an oral decongestant.
Definition
ChEBI: A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.
General Description
(Neo-Synephrine, a prototypical selectivedirect-acting 1-agonist) differs from E only inlacking a p-OH group. It is orally active, and its DOA isabout twice that of E because it lacks the catechol moietyand thus is not metabolized by COMT. However, its oralbioavailability is less than 10% because of its hydrophilicproperties (log P＝0.3), intestinal 3 -O-glucuronidation/sulfation and metabolism by MAO. Lacking the p-OHgroup, it is less potent than E and NE but it is a selectiveα1-agonist and thus a potent vasoconstrictor. It is usedsimilarly to metaraminol and methoxamine for hypotension.Another use is in the treatment of severe hypotensionresulting from either shock or drug administration. It alsohas widespread use as a nonprescription nasal decongestantin both oral and topical preparations. When applied tomucous membranes, it reduces congestion and swelling byconstricting the blood vessels of the membranes. In theeye, it is used to dilate the pupil and to treat open-angleglaucoma. In addition, it is used in spinal anesthesia toprolong the anesthesia and to prevent a drop in blood pressureduring the procedure. It is relatively nontoxic and produceslittle CNS stimulation. Metaraminol is just anotherexample.
Clinical Use
Phenylephrine is a potent direct-acting α1-agonist with clinical effects similar to those of noradrenaline. It causes widespread vasoconstriction with an increase in arterial pressure, reflex bradycardia and decrease in cardiac output. It may be administered by i.v. bolus (50–100μg boluses) and i.v. infusion (50–150μgmin –1) to maintain arterial pressure during general anaesthesia or other causes of low SVR. It may also be used topically as a nasal decongestant or mydriatic. There is some evidence suggesting a paradoxical reduction in cerebral oxygen delivery.
Safety Profile
Poison by ingestion, subcutaneous, intravenous, intraperitoneal, and intraduodenal routes. Human systemic effects by ocular route: blood pressure increase. An experimental teratogen. Other experimental reproductive effects. A nasal decongestant. When heated to decomposition it emits toxic fumes of NOx.
Phenylephrine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
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| Indogulf Group | 91-22-23455220 | Maharashtra, India | 249 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| ANWITA APIS | 58 |
| Aarti Industries Limited (AIL) | 58 |
| Ipca Laboratories Ltd | 58 |
| Beloorbayir Biotech Ltd | 58 |
| Pharma Affiliates | 58 |
| Opulent Pharma | 58 |
| U. K. Vet Chem | 58 |
| K Kumar & Co. | 58 |
| Sparkle Chem | 58 |
| Indogulf Group | 58 |