(R)-Phenylephrine Hydrochlorid
- CAS No.
- 61-76-7
- Chemical Name:
- (R)-Phenylephrine Hydrochlorid
- Synonyms
- PHENYLEPHRINE HCL;PHENYLEPHRINE HYDROCHLORIDE;Phenylephrine Hydrochlorid;(R)-(-)-PHENYLEPHRINE HYDROCHLORIDE;Phenylephrine hydrochloride CRS;L(-)-PHENYLEPHRINE HYDROCHLORIDE;3-Hydroxy-alpha-(methylaminomethyl)benzyl alcohol;uri;fenox;efricel
- CBNumber:
- CB6762113
- Molecular Formula:
- C9H13NO2.ClH
- Molecular Weight:
- 203.67
- MOL File:
- 61-76-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/3 17:07:09
| Melting point | 143-145 °C(lit.) |
|---|---|
| alpha | -47 º (c=2, H2O) |
| refractive index | -45.5 ° (C=1, H2O) |
| Flash point | 9℃ |
| storage temp. | 2-8°C |
| solubility | Freely soluble in water and in ethanol (96 per cent). |
| form | Crystalline Powder |
| pka | pK1 8.77; pK2 9.84(at 25℃) |
| color | White to almost white |
| PH | pH (10g/L, 25℃) : 4.5～5.5 |
| Water Solubility | >=10 g/100 mL at 21 ºC |
| Merck | 14,7286 |
| BRN | 4158948 |
| Stability | Hygroscopic |
| LogP | -0.310 |
| CAS DataBase Reference | 61-76-7(CAS DataBase Reference) |
| EPA Substance Registry System | Phenylephrine hydrochloride (61-76-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H317 | |||||||||
| Precautionary statements | P261-P264-P270-P280-P301+P312-P302+P352 | |||||||||
| Hazard Codes | Xn,T,F | |||||||||
| Risk Statements | 22-36/37/38-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 26-36-37/39-45-36/37-16-7 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DO7525000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29225090 | |||||||||
| Toxicity | LD50 in rats (mg/kg): 17 ±1.1 i.p.; 33 ±2.0 s.c. (Warren, Werner) | |||||||||
| NFPA 704 |
|
(R)-Phenylephrine Hydrochlorid price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | P6126 | (R)-(−)-Phenylephrine hydrochloride powder | 61-76-7 | 5G | ₹6062 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P6126 | (R)-(−)-Phenylephrine hydrochloride powder | 61-76-7 | 10G | ₹9980.65 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1017 | Phenylephrine Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | 61-76-7 | 500MG | ₹9590.95 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P6126 | (R)-(−)-Phenylephrine hydrochloride powder | 61-76-7 | 25G | ₹18662.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P6126 | (R)-(−)-Phenylephrine hydrochloride powder | 61-76-7 | 50G | ₹30981.15 | 2022-06-14 | Buy |
(R)-Phenylephrine Hydrochlorid Chemical Properties,Uses,Production
Description
R-(-)-Phenylephrine is an adrenergic α1A receptor agonist (Ki = 1.4 μM) that demonstrates selectivity against the α1B and α1C receptor subtypes (Kis = 23.9 and 47.8 μM, respectively). By stimulating adrenergic α1 receptors, L-phenylephrine can induce aortic smooth muscle contractions, although reported relative affinity and potency values in rabbit are 5-fold weaker compared to that of L-norepinephrine . This compound is frequently used to precontract smooth muscle in preparations designed to study the properties of various vasodilator agents.
Chemical Properties
white to almost white crystalline powder
Uses
(R)-Phenylephrine Hydrochloride is an α-Adrenergic agonist. Mydriatic; decongestant.
Definition
ChEBI: A hydrochloride that is the monohydrochloride salt of phenylephrine.
General Description
Odorless white microcrystalline powder. Bitter taste. pH (1% aqueous solution) about 5.
Air & Water Reactions
May be sensitive to prolonged exposure to air and light. Water soluble.
Reactivity Profile
Phenylephrine hydrochloride is incompatible with acids, acid chlorides, acid anhydrides and oxidizing agents. Phenylephrine hydrochloride is also incompatible with butacaine, alkalis and ferric salts.
Fire Hazard
Flash point data for Phenylephrine hydrochloride are not available; however, Phenylephrine hydrochloride is probably combustible.
Biological Activity
α 1 -adrenoceptor agonist; pK i values are 5.86, 4.87 and 4.70 for α 1D , α 1B and α 1A receptors respectively.
Contact allergens
Phenylephrine hydrochloride is an alpha-adrenergic agonist, used as a mydriatic and decongestant in eyedrops.
Safety Profile
Poison by ingestion, intraperitoneal, subcutaneous, intravenous,and intramuscular routes. Mutation data reported. When heated to decomposition it emits very toxic fumes of HCl and NOx.
(R)-Phenylephrine Hydrochlorid Preparation Products And Raw materials
Raw materials
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