N-ACETYL-4-BENZOQUINONE IMINE

N-ACETYL-4-BENZOQUINONE IMINE Properties

Melting point	74-75
Boiling point	255.6±43.0 °C(Predicted)
Density	1.13±0.1 g/cm3(Predicted)
storage temp.	-70°C
solubility	Chloroform (Slightly, Sonicated), DMSO (Slightly)
form	Solid
pka	-3.37±0.20(Predicted)
color	Pale Yellow to Very Dark Red
Stability	Temperature, Moisture, Light, and Oxygen Sensitive
CAS DataBase Reference	50700-49-7

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362

WGK Germany

3

RTECS

AC6960000

HS Code

2902110000

Toxicity

LD50 i.p. in male BALB/c mice: 20 mg/kg (Dahlin, Nelson)

NFPA 704

	0
2		0

N-ACETYL-4-BENZOQUINONE IMINE price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	A7300	N-Acetylbenzoquinoneimine	50700-49-7	1MG	₹23912.43	2022-06-14	Buy
Sigma-Aldrich(India)	A7300	N-Acetylbenzoquinoneimine	50700-49-7	5MG	₹91611.98	2022-06-14	Buy

Product number	Packaging	Price	Buy
A7300	1MG	₹23912.43	Buy
A7300	5MG	₹91611.98	Buy

N-ACETYL-4-BENZOQUINONE IMINE Chemical Properties,Uses,Production

Description

N-Acetyl-4-benzoquinone imine (NAPQI) is a cytochrome P450 3A4 and 2E1 metabolite of acetaminophen that can be toxic to the liver when acetaminophen is consumed in large doses. At therapeutic doses of acetaminophen, NAPQI is inactivated by conjugation with glutathione. However, following toxic doses of acetaminophen, available liver reserves of glutathione are quickly depleted due to clearance of excess NAPQI, which enables hepatic proteins to become covalently modified by reactive metabolites and eventually results in hepatocyte necrosis.

Chemical Properties

Yellow Crystalline Solid

Uses

N-Acetyl-4-benzoquinone imine (NAPQI) is a cytochrome P450 3A4 and 2E1 metabolite of acetaminophen that can be toxic to the liver when acetaminophen is consumed in large doses. At therapeutic doses of acetaminophen, NAPQI is inactivated by conjugation with glutathione. However, following toxic doses of acetaminophen, available liver reserves of glutathione are quickly depleted due to clearance of excess NAPQI, which enables hepatic proteins to become covalently modified by reactive metabolites and eventually results in hepatocyte necrosis.

N-ACETYL-4-BENZOQUINONE IMINE Preparation Products And Raw materials

Raw materials

Preparation Products

3-CHLORO-4-HYDROXYACETANILIDE Acetaminophen

N-ACETYL-4-BENZOQUINONE IMINE Suppliers

Global( 85)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 15319487004	China	4088	58	Inquiry
LEAP CHEM CO., LTD.	+86-852-30606658	China	24738	58	Inquiry
China National Standard Pharmaceutical Corporation Limited	+8615391658522	China	11927	58	Inquiry
LEAPCHEM CO., LTD.	+86-852-30606658	China	43348	58	Inquiry
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	China	33350	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	52927	58	Inquiry
Nantong Hanfang Biotechnology Co. , Ltd.	18616537568	China	30968	58	Inquiry
RD International Technology Co., Limited	18024082417	China	9268	58	Inquiry
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	China	8141	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Shaanxi Dideu Medichem Co. Ltd	58
LEAP CHEM CO., LTD.	58
China National Standard Pharmaceutical Corporation Limited	58
LEAPCHEM CO., LTD.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58
Nantong Hanfang Biotechnology Co. , Ltd.	58
RD International Technology Co., Limited	58
MedBioPharmaceutical Technology Inc	58

50700-49-7(N-ACETYL-4-BENZOQUINONE IMINE)Related Search:

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