N-ACETYL-4-BENZOQUINONE IMINE
![N-ACETYL-4-BENZOQUINONE IMINE Structure](CAS/GIF/50700-49-7.gif)
- CAS No.
- 50700-49-7
- Chemical Name:
- N-ACETYL-4-BENZOQUINONE IMINE
- Synonyms
- napqi;N-Acetylimidoquinone;N-ACETYL-P-BENZOQUINONE IMINE;N-Acetyl-p-benzoquinonimine;Chebi:29132;acetimidoquinone;n-acetyl-p-quinonimine;N-ACETYLBENZOQUINONE-IMINE;N-ACETYL-PARA-QUINONEIMINE;N-acrtyl Benzoquinoneimine
- CBNumber:
- CB0696629
- Molecular Formula:
- C8H7NO2
- Molecular Weight:
- 149.15
- MOL File:
- 50700-49-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 9:02:16
Melting point | 74-75 |
---|---|
Boiling point | 255.6±43.0 °C(Predicted) |
Density | 1.13±0.1 g/cm3(Predicted) |
storage temp. | -70°C |
solubility | Chloroform (Slightly, Sonicated), DMSO (Slightly) |
form | Solid |
pka | -3.37±0.20(Predicted) |
color | Pale Yellow to Very Dark Red |
Stability | Temperature, Moisture, Light, and Oxygen Sensitive |
CAS DataBase Reference | 50700-49-7 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319 | |||||||||
Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | AC6960000 | |||||||||
HS Code | 2902110000 | |||||||||
Toxicity | LD50 i.p. in male BALB/c mice: 20 mg/kg (Dahlin, Nelson) | |||||||||
NFPA 704 |
|
N-ACETYL-4-BENZOQUINONE IMINE price More Price(2)
N-ACETYL-4-BENZOQUINONE IMINE Chemical Properties,Uses,Production
Description
N-
Chemical Properties
Yellow Crystalline Solid
Uses
N-Acetyl-4-benzoquinone imine (NAPQI) is a cytochrome P450 3A4 and 2E1 metabolite of acetaminophen that can be toxic to the liver when acetaminophen is consumed in large doses. At therapeutic doses of acetaminophen, NAPQI is inactivated by conjugation with glutathione. However, following toxic doses of acetaminophen, available liver reserves of glutathione are quickly depleted due to clearance of excess NAPQI, which enables hepatic proteins to become covalently modified by reactive metabolites and eventually results in hepatocyte necrosis.
N-ACETYL-4-BENZOQUINONE IMINE Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | China | 4088 | 58 | Inquiry |
LEAP CHEM CO., LTD. | +86-852-30606658 | China | 24738 | 58 | Inquiry |
China National Standard Pharmaceutical Corporation Limited | +8615391658522 | China | 11927 | 58 | Inquiry |
LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | China | 33350 | 58 | Inquiry |
Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
Nantong Hanfang Biotechnology Co. , Ltd. | 18616537568 | China | 30968 | 58 | Inquiry |
RD International Technology Co., Limited | 18024082417 | China | 9268 | 58 | Inquiry |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | China | 8141 | 58 | Inquiry |
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