N-ACETYL-4-BENZOQUINONE IMINE
N-ACETYL-4-BENZOQUINONE IMINE
- CAS:
- 50700-49-7
- MF:
- C8H7NO2
- MW:
- 149.15
Suppliers by country/region
Properties
- Melting point:
- 74-75
- Boiling point:
- 255.6±43.0 °C(Predicted)
- Density
- 1.13±0.1 g/cm3(Predicted)
- storage temp.
- -70°C
- solubility
- Chloroform (Slightly, Sonicated), DMSO (Slightly)
- form
- Solid
- pka
- -3.37±0.20(Predicted)
- color
- Pale Yellow to Very Dark Red
- Stability:
- Temperature, Moisture, Light, and Oxygen Sensitive
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H315-H319
- Precautionary statements
- P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362
- WGK Germany
- 3
- RTECS
- AC6960000
- HS Code
- 2902110000
- Toxicity
- LD50 i.p. in male BALB/c mice: 20 mg/kg (Dahlin, Nelson)
Use
N-Acetyl-4-benzoquinone imine (NAPQI) is a cytochrome P450 3A4 and 2E1 metabolite of acetaminophen that can be toxic to the liver when acetaminophen is consumed in large doses. At therapeutic doses of acetaminophen, NAPQI is inactivated by conjugation with glutathione. However, following toxic doses of acetaminophen, available liver reserves of glutathione are quickly depleted due to clearance of excess NAPQI, which enables hepatic proteins to become covalently modified by reactive metabolites and eventually results in hepatocyte necrosis.
0 India supplier list of "N-ACETYL-4-BENZOQUINONE IMINE"
- Product Name:N-Acetylbenzoquinoneimine
- Products Intro:Brand:sigma aldrich | Product Number:A7300
- Company Type: Trader
- Country/Region: Bangalore,INDIA
- Product Name:N-Acetyl-4-benzoquinoneImine
- Products Intro:Brand:clearsynth | Product Number:CS-T-47138
- Company Type: Trader
- Country/Region: Hyderabad,INDIA
- Product Name:N-Acetylbenzoquinoneimine
- Products Intro:Purity: 99.0% | Package: 100g;1kg;5kg;25kg
- Company Type: Trader
- Country/Region: CHINA
- Product Name:N-Acetylbenzoquinoneimine
- Products Intro:Package: 1g; 5g; 25g; 1kg; 5kg; 25kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: pharmaceuticals,intermediates,fine chemicals,screening compounds,building blocks
- Product Name:N-Acetylbenzoquinoneimine
- Products Intro:Package: 1g; 5g; 25g; 1kg; 5kg; 25kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Pharmaceutical intermediate
- Product Name:N-Acetyl-4-benzoquinone Imine
- Products Intro:Purity: 98% | Package: 1mg, 5mg
- Company Type: Trader
- Country/Region: CHINA
- Product Name:N-Acetyl-4-benzoquinone Imine
- Products Intro:Purity: 90% | Package: $899.9/1mg;$3169.9/5mg;Bulk package | CustNote: 90%
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Chemicals and BioChemicals,Materials Science,ligands acting on targets,Proteins,Antibodies
- Product Name:N-Acetyl-4-benzoquinone Imine
- Products Intro:Purity: 0.99 | Package: 100g;1kg;5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Isopropyl alcohol,Polyvinyl chlorid,Dodecylbenzenesulphonic acid,Dimethyl Sulfoxide,Titanium Dioxide
- Product Name:Phenylephrine Impurity 8
- Products Intro:Purity: 95% | Package: 100mg/RMB 1000;100mg/RMB 1000;100mg/RMB 1000
- Company Type: Trader
- Country/Region: CHINA
-
1mg$221.005mg$897.00
- Product Name:N-Acetylbenzoquinoneimine
- Products Intro:Brand: Sigma-Aldrich | Product Number: A7300
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: cof,mof