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ChemicalBook > Product Catalogue >Analytical Chemistry >Standard >Pharmaceutical Impurity Reference Standards >N-ACETYL-4-BENZOQUINONE IMINE

N-ACETYL-4-BENZOQUINONE IMINE

N-ACETYL-4-BENZOQUINONE IMINE Structure
  • ₹23912.43 - ₹91611.98
  • Product name: N-ACETYL-4-BENZOQUINONE IMINE
  • CAS: 50700-49-7
  • MF: C8H7NO2
  • MW: 149.15
  • EINECS:
  • MDL Number:MFCD00078909
  • Synonyms:N-ACETYLBENZOQUINONE-IMINE;N-N-Acetyl-4-benzoquinone Imine;N-ACETYL-PARA-QUINONEIMINE;N-Acetyl-p-benzoquinone imine (NAPQI), 98%;4-(Acetylimino)-2,5-cyclohexadien-1-one;N-(4-Oxo-1-cyclohexa-2,5-dienylidene)acetamide, N-Acetyl-p-benzo-quinone imine, NAPQI;N-Acetyl-1,4-benzoquinone imine;Chebi:29132
2 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 1MG
  • 5MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberA7300
  • Product descriptionN-Acetylbenzoquinoneimine
  • Packaging1MG
  • Price₹23912.43
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA7300
  • Product descriptionN-Acetylbenzoquinoneimine
  • Packaging5MG
  • Price₹91611.98
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) A7300 N-Acetylbenzoquinoneimine 1MG ₹23912.43 2022-06-14 Buy
Sigma-Aldrich(India) A7300 N-Acetylbenzoquinoneimine 5MG ₹91611.98 2022-06-14 Buy

Properties

Melting point :74-75
Boiling point :255.6±43.0 °C(Predicted)
Density :1.13±0.1 g/cm3(Predicted)
storage temp. :-70°C
solubility :Chloroform (Slightly, Sonicated), DMSO (Slightly)
form :Solid
pka :-3.37±0.20(Predicted)
color :Pale Yellow to Very Dark Red
Stability :Temperature, Moisture, Light, and Oxygen Sensitive
CAS DataBase Reference :50700-49-7

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.

Description

N-Acetyl-4-benzoquinone imine (NAPQI) is a cytochrome P450 3A4 and 2E1 metabolite of acetaminophen that can be toxic to the liver when acetaminophen is consumed in large doses. At therapeutic doses of acetaminophen, NAPQI is inactivated by conjugation with glutathione. However, following toxic doses of acetaminophen, available liver reserves of glutathione are quickly depleted due to clearance of excess NAPQI, which enables hepatic proteins to become covalently modified by reactive metabolites and eventually results in hepatocyte necrosis.

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