3-AMINO-1,2,4-BENZOTRIAZINE-1,4-DIOXIDE
- CAS No.
- 27314-97-2
- Chemical Name:
- 3-AMINO-1,2,4-BENZOTRIAZINE-1,4-DIOXIDE
- Synonyms
- TPZ;TIRAPAZAMINE;SR-4233;CS-2810;Tirazone;SR 259075;Tirazamin;NSC130181;NSC 130181;NSC-130181
- CBNumber:
- CB5442522
- Molecular Formula:
- C7H6N4O2
- Molecular Weight:
- 178.15
- MOL File:
- 27314-97-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 17:06:35
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DM0671500 | |||||||||
| HS Code | 2933.99.7500 | |||||||||
| NFPA 704 |
|
3-AMINO-1,2,4-BENZOTRIAZINE-1,4-DIOXIDE price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0552 | Tirapazamine ≥98% (HPLC) | 27314-97-2 | 10MG | ₹7653.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0552 | Tirapazamine ≥98% (HPLC) | 27314-97-2 | 50MG | ₹15544.7 | 2022-06-14 | Buy |
| TCI Chemicals (India) | T3823 | Tirapazamine | 27314-97-2 | 50MG | ₹5200 | 2022-05-26 | Buy |
| TCI Chemicals (India) | T3823 | Tirapazamine | 27314-97-2 | 250MG | ₹18500 | 2022-05-26 | Buy |
3-AMINO-1,2,4-BENZOTRIAZINE-1,4-DIOXIDE Chemical Properties,Uses,Production
Description
Tirapazamine is a hypoxia-activated anticancer agent. It is converted to an oxidizing radical under hypoxic conditions and can induce single- and double-strand breaks in DNA, formation of trapped topoisomerase I- and II-DNA complexes, and other chromosomal aberrations, leading to cytotoxicity. Tirapazamine induces hypoxia-enhanced cytotoxicity in DT40 cells (IC50s = 1.02 and 4.34 μM in hypoxic and normoxic conditions, respectively). It also induces cytotoxicity in HT-1080 and A549 cells in a concentration-dependent manner under hypoxic conditions. In vivo, tirapazamine sensitizes tumors to cisplatin in a mouse RIF-1 fibrosarcoma tumor model. Tirapazamine (0.08 mmol/kg) also sensitizes tumors to fractionated irradiation in a FaDu hypopharyngeal squamous cell carcinoma mouse xenograft model.
Chemical Properties
Orange Needles
Uses
A bioreductive anticancer agent. Selectively toxic to cells under hypoxic conditions. An antineoplastic
Definition
ChEBI: A member of the class of benzotriazines that is 1,2,4-benzotriazine carrying an amino substituent at position 3 and two oxido substituents at positions 1 and 4.
3-AMINO-1,2,4-BENZOTRIAZINE-1,4-DIOXIDE Preparation Products And Raw materials
Raw materials
1of2
chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32836 | 60 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49392 | 58 | Inquiry |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | China | 9640 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| CR Corporation Limited | +8613062833949 | China | 8647 | 58 | Inquiry |