Butylparaben
- CAS No.
- 94-26-8
- Chemical Name:
- Butylparaben
- Synonyms
- BUTYL P-HYDROXYBENZOATE;BUTYL 4-HYDROXYBENZOATE;SPF;butyl parabens;Butyl parahydroxybenzoate CRS;P-HYDROXYBENZOIC ACID N-BUTYL ESTER;butoben;solbrolb;FEMA 2203;Lexgard B
- CBNumber:
- CB5466788
- Molecular Formula:
- C11H14O3
- Molecular Weight:
- 194.23
- MOL File:
- 94-26-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/14 11:56:19
| Melting point | 67-70 °C(lit.) |
|---|---|
| Boiling point | 156-157 °C3.5 mm Hg(lit.) |
| Density | 1.28 |
| vapor pressure | 0.002-0.113Pa at 20-50℃ |
| refractive index | 1.5115 (estimate) |
| FEMA | 2203 | BUTYL P-HYDROXY BENZOATE |
| Flash point | 181℃ |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO, ethyl acetate, methanol. |
| pka | pKa 8.5 (Uncertain) |
| form | Crystalline Powder |
| color | White to almost white |
| Odor | very faint phenolic |
| Odor Type | bland |
| Water Solubility | <0.1 g/100 mL at 17 ºC |
| Merck | 14,1584 |
| JECFA Number | 870 |
| BRN | 1103741 |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents, strong alkalies. |
| InChIKey | QFOHBWFCKVYLES-UHFFFAOYSA-N |
| LogP | 3.57 |
| CAS DataBase Reference | 94-26-8(CAS DataBase Reference) |
| NIST Chemistry Reference | P-hydroxybenzoic acid, n-butyl ester(94-26-8) |
| EPA Substance Registry System | Butylparaben (94-26-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H318 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P362+P364 | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 22-24/25-37/39-26 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | DH1980000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29182900 | |||||||||
| NFPA 704 |
|
Butylparaben price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | W220302 | Butyl 4-hydroxybenzoate ≥99% | 94-26-8 | 1SAMPLE | ₹4990.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W220302 | Butyl 4-hydroxybenzoate ≥99% | 94-26-8 | 1KG | ₹8724.95 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W220302 | Butyl 4-hydroxybenzoate ≥99% | 94-26-8 | 5KG | ₹57469.93 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1022 | Butylparaben Pharmaceutical Secondary Standard; Certified Reference Material | 94-26-8 | 1G | ₹8465.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1022 | Butylparaben Pharmaceutical Secondary Standard; Certified Reference Material | 94-26-8 | 10G | ₹47489.28 | 2022-06-14 | Buy |
Butylparaben Chemical Properties,Uses,Production
Description
Butylparaben is an antimicrobial agent used in pharmaceutical suspensions. It is act by inhibiting DNA, RNA, and enzymes (eg, ATPase and phosphotransferase) synthesis. Butylparaben may be used alone or with other parabens, chiefly methylparaben and/or propylparaben, in medications. It is common in many liquid and solid (gel cap) OTC products such as Tylenol, Drixoral, Maalox, and Mylanta. Unfortunately, butylparaben concentrations were seldom identified for OTC or prescription products. No attempt was made to identify butylparaben-containing dietary supplements.
Chemical Properties
Butylparaben occurs as colorless crystals or a white, crystalline, odorless or almost odorless, tasteless powder.
Preparation
Butyl paraben is prepared by esterifying p-hydroxybenzoic acid with butyl alcohol in the presence of an acid catalyst, such as sulfuric acid, and an excess of the specific alcohol.
Production Methods
Butylparaben is prepared by esterification of p-hydroxybenzoic acid with n-butanol.
General Description
Odorless white crystals or crystalline powder. Tasteless, but numbs the tongue. Aqueous solutions slightly acidic to litmus.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Butylparaben is incompatible with strong oxidizing agents and strong caustics.
Fire Hazard
Flash point data for Butylparaben are not available; however, Butylparaben is probably combustible.
Pharmaceutical Applications
Butylparaben is widely used as an antimicrobial preservative in
cosmetics and pharmaceutical formulations.
It may be used either alone or in combination with other paraben
esters or with other antimicrobial agents. In cosmetics, it is the
fourth most frequently used preservative.
As a group, the parabens are effective over a wide pH range and
have a broad spectrum of antimicrobial activity, although they are
most effective against yeasts and molds.
Owing to the poor solubility of the parabens, paraben salts,
particularly the sodium salt, are frequently used in formulations.
However, this may raise the pH of poorly buffered formulations.
See Methylparaben for further information.
Contact allergens
This substance is one of the parabens family. Parabens are esters formed by p-hydroxybenzoic acid and an alcohol. They are largely used as biocides in cosmetics and toiletries, medicaments, or food. They have synergistic power with other biocides. Parabens can induce allergic contact dermatitis, mainly in chronic dermatitis and wounded skin.
Safety
Butylparaben and other parabens are widely used as antimicrobial
preservatives in cosmetics and oral and topical pharmaceutical
formulations.
Systemically, no adverse reactions to parabens have been
reported, although they have been associated with hypersensitivity
reactions generally appearing as contact dematitis. Immediate
reactions with urticaria and bronchospasm have occurred rarely.
See Methylparaben for further information.
LD50 (mouse, IP): 0.23 g/kg
LD50 (mouse, oral): 13.2 g/kg
storage
Aqueous butylparaben solutions at pH 3–6 can be sterilized by autoclaving, without decomposition. At pH 3–6, aqueous solutions are stable (less than 10% decomposition) for up to about 4 years at room temperature, while solutions at pH 8 or above are subject to rapid hydrolysis (10% or more after about 60 days at room temperature).
Incompatibilities
The antimicrobial activity of butylparaben is considerably reduced
in the presence of nonionic surfactants as a result of micellization.
Absorption of butylparaben by plastics has not been reported but
appears probable given the behavior of other parabens. Some
pigments, e.g. ultramarine blue and yellow iron oxide, absorb
butylparaben and thus reduce its preservative properties.
Butylparaben is discolored in the presence of iron and is subject
to hydrolysis by weak alkalis and strong acids.
Regulatory Status
Butylparaben is regulated by the U.S. Environmental Protection Agency (EPA) under the Toxic Substances Control Act (TSCA) and the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA). In 1998 its pesticide registration status was listed as "cancelled" (U.S. EPA, 2003).
Included in the FDA Inactive Ingredients Database (injections; oral capsules, solutions, suspensions, syrups and tablets; rectal, and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.
Butylparaben Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Rasula Pharmaceuticals And Fine Chemicals | +91-4023774210 +91-4023771063 | Telangana, India | 7 | 58 | Inquiry |
| Salicylates and Chemicals Pvt. Ltd. | +91-8879630551 +91-8898005838 | Maharashtra, India | 61 | 58 | Inquiry |
| JD Chem India | +91-9899117932 +91-9555260045 | New Delhi, India | 41 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| Scientific OEM | +91-22- 2343 7546 / 2341 3094 | New Delhi, India | 1996 | 38 | Inquiry |
| Laxachem Organics Pvt. Ltd | +91-22-2343 8127 | New Delhi, India | 13 | 30 | Inquiry |
| Supplier | Advantage |
|---|---|
| Rasula Pharmaceuticals And Fine Chemicals | 58 |
| Salicylates and Chemicals Pvt. Ltd. | 58 |
| JD Chem India | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
| CHEMSWORTH | 30 |
| Scientific OEM | 38 |
| Laxachem Organics Pvt. Ltd | 30 |
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