O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI

CAS No.: 132489-69-1

Chemical Name:: O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI

Synonyms: (Z)-Pugnac;(Z)-PUGNAc min. 99%;PUGNAc extrapure, 95%;O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI;acetamidodeoxy-D-glucopyranosylideneamino phenylcarbamate;n-acetylglucosaminono-1,5-lactoneo-(phenylcarbamoyl)oxime;O-(2-Acetamido-2-deoxy-D-glucopyranosylidenamino) N-phenylcarbamate;O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino-Z-N-phenylcarbamate;(Z)-O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenylcarbamate;O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenyl carbamate ,97%

CBNumber:: CB5503122

Molecular Formula:: C15H19N3O7

Molecular Weight:: 353.33

MOL File:: 132489-69-1.mol

MSDS File:: SDS

Modify Date:: 2023/6/30 15:45:59

Request For Quotation

O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI Properties

Melting point	172-175°C
Density	1.53
storage temp.	-20°C
solubility	Soluble in DMSO (up to 35 mg/ml)
form	solid
pka	11.85±0.70(Predicted)
color	White
BRN	4274031
Stability	Moisture and Temperature Sensitive

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P280-P302+P352-P362+P364
WGK Germany	3
HS Code	29329990

O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI price More Price(3)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	A7229	PUGNAc ≥95% (HPLC)	132489-69-1	5MG	₹18900.45	2022-06-14	Buy
Sigma-Aldrich(India)	A7229	PUGNAc ≥95% (HPLC)	132489-69-1	10MG	₹34910.63	2022-06-14	Buy
SRL	59750	PUGNAc extrapure, 95%	132489-69-1	5mg	₹16230	2022-05-26	Buy

Product number	Packaging	Price	Buy
A7229	5MG	₹18900.45	Buy
A7229	10MG	₹34910.63	Buy
59750	5mg	₹16230	Buy

O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI Chemical Properties,Uses,Production

Description

Proteins can be modified post-translationally by the addition of O-linked N-acetylglucosamine (O-GlcNAc). Nuclear cytoplasmic O-GlcNAcase and acetyltransferase (NCOAT) is a β-N-acetylglucosaminidase that removes GlcNAc from O-glycosylated proteins. PUGNAc is a (phenylcarbamoyl)oxime analog of GlcNAc that reversibly inhibits NCOAT (K_i = 40-110 nM). It also less potently inhibits other hexosaminidases and exochitinases. (Z)-PUGNAc is a stereoisomer of PUGNAc that is a more potent inhibitor of NCOAT than the (E) isomer, both in vitro and in cells.

Chemical Properties

White to Off-White Solid

Uses

An inhibitor of O-GlcNAcase, hexosaminidase A, and hexosaminidase B

Biological Activity

O -GlcNAc- β - N -acetylglucosaminidase ( O -GlcNAcase) and β -hexosaminidase inhibitor (K i values are 46 and 36 nM respectively) that increases O -GlcNAc levels ~ 2-fold in HT29 cells. Z -linked isomer is more potent than the E isomer.

O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI Preparation Products And Raw materials

Raw materials

O-(2-ACETAMIDO-3,4,6-TRI-O-ACETYL-D-GLUCOPYRANOSYLIDENE)AMINO N-PHENYL CARBAMATE 2-ACETAMIDO-2-DEOXY-D-GLUCONHYDROXIMO-1,5-LACTONE 1-N,3,4,6-TETRAACETATE 2-ACETAMIDO-3,4,6-TRI-O-ACETYL-2-DEOXY-D-GLUCOHYDROXIMO-1,5-LACTONE

Preparation Products

O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI Suppliers

Global( 101)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Sisco Research Laboratories Pvt. Ltd.	+91-22-4268 5800	Mumbai, India	4317	58	Inquiry
Triveni chemicals	08048762458	New Delhi, India	6093	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29900	58	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	China	23556	58	Inquiry
Wuhan Fortuna Chemical Co., Ltd	+86-027-59207850	China	5999	58	Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	China	8474	58	Inquiry

Supplier	Advantage
Sisco Research Laboratories Pvt. Ltd.	58
Triveni chemicals	58
CLEARSYNTH LABS LTD.	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
ANHUI WITOP BIOTECH CO., LTD	58
Wuhan Fortuna Chemical Co., Ltd	58
Wuhan Topule Biopharmaceutical Co., Ltd	58

132489-69-1(O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI)Related Search:

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2-ACETAMIDO-2-DEOXY-D-GLUCONHYDROXIMO-1,5-LACTONE 4-HYDROXY-BUTYRIMIDIC ACID ETHYL ESTER 5-HYDROXYPENTANAL OXIME AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE Ethyl acetohydroxamate

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(Z)-Pugnac O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino-Z-N-phenylcarbamate O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenyl carbamate ,97% (Z)-O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenylcarbamate (Z)-PUGNAc min. 99% O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI 2-(AcetylaMino)-2-deoxy-N-[[(phenylaMino)carbonyl]oxy]-D-gluconiMidic Acid δ-Lactone (1Z)-2-(Acetylamino)-2-deoxy-N-[[(phenylamino)carbonyl]oxy]-D-gluconimidic acid delta-lactone n-acetylglucosaminono-1,5-lactoneo-(phenylcarbamoyl)oxime acetamidodeoxy-D-glucopyranosylideneamino phenylcarbamate O-(2-Acetamido-2-deoxy-D-glucopyranosylidenamino) N-phenylcarbamate (5R,6R,7S,8R,Z)-6,7-Dihydroxy-8-(hydroxymethyl)-2,3-dioxo-N-((phenylcarbamoyl)oxy)-1,4-oxazocane-5-carbimidic acid D-Gluconimidic acid, 2-(acetylamino)-2-deoxy-N-[[(phenylamino)carbonyl]oxy]-, δ-lactone, (1Z)- PUGNAc extrapure, 95% 132489-69-1 Carbohydrates & Derivatives Glycosidase Inhibitors Inhibitors