Tris(2-carboxyethyl)phosphine hydrochloride
- CAS No.
- 51805-45-9
- Chemical Name:
- Tris(2-carboxyethyl)phosphine hydrochloride
- Synonyms
- TCEP HCL;TCEP Solution;Tris(2-carboxyethyl)phosphine hydrochloride, 98% 1GR;TCEP*HCL;TCEP-HCI;0.5M TCEP;500 MM TCEP;TCEP, HYDROCHLORIDE;)phosphine hydrochL;TCEP-HCl, OMniPur(R)
- CBNumber:
- CB8263816
- Molecular Formula:
- C9H15O6P.ClH
- Molecular Weight:
- 286.65
- MOL File:
- 51805-45-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/5 17:10:12
| Melting point | 177 °C |
|---|---|
| Density | 1.041 g/mL at 25 °C |
| refractive index |
n |
| storage temp. | 2-8°C |
| solubility | H2O: 50 mg/mL |
| form | powder |
| pka | 7.66(at 25℃) |
| color | white |
| PH | 7.0(aqueous solution; pH was adjusted with ammonium hydroxide) |
| Water Solubility | Soluble in water and methanol. |
| Sensitive | Moisture Sensitive |
| λmax |
λ: 260 nm Amax: 0.05 λ: 280 nm Amax: 0.03 |
| Merck | 14,9085 |
| BRN | 3724376 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month. |
| InChIKey | PBVAJRFEEOIAGW-UHFFFAOYSA-N |
| CAS DataBase Reference | 51805-45-9(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P260-P280-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | C,Xi | |||||||||
| Risk Statements | 36/38-36/37/38-34 | |||||||||
| Safety Statements | 26-37/39-36/37/39-27-45 | |||||||||
| RIDADR | UN 3261 8/PG 2 | |||||||||
| WGK Germany | 2 | |||||||||
| F | 10 | |||||||||
| TSCA | No | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29319090 | |||||||||
| NFPA 704 |
|
Tris(2-carboxyethyl)phosphine hydrochloride price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C4706 | Tris(2-carboxyethyl)phosphine hydrochloride powder | 51805-45-9 | 2G | ₹20110 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C4706 | Tris(2-carboxyethyl)phosphine hydrochloride powder | 51805-45-9 | 10G | ₹73340 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C4706 | Tris(2-carboxyethyl)phosphine hydrochloride powder | 51805-45-9 | 50G | ₹339114.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 75259 | Tris(2-carboxyethyl)phosphine hydrochloride BioUltra, ≥98% (NMR) | 51805-45-9 | 1G | ₹13585.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 75259 | Tris(2-carboxyethyl)phosphine hydrochloride BioUltra, ≥98% (NMR) | 51805-45-9 | 10G | ₹69388.25 | 2022-06-14 | Buy |
Tris(2-carboxyethyl)phosphine hydrochloride Chemical Properties,Uses,Production
Chemical Properties
White Crystalline Solid
Uses
TCEP (Tris(2-carboxyethyl)phosphine hydrochloride) is an alternative which is not pungent, more stable and works even at low pH. It is more selective, i.e. do not reduce metals and buried disulfides.
Preparation
The preparation of Tris(2-carboxyethyl)phosphine hydrochloride is as follows:Trimethyl 3,3 ', 3 "-phosphine triphenylpropionate (92.5g, 0.28mol) prepared as described above was added to a 250 ml reaction flask under mechanical stirring conditions and a molar ratio of 12mol/(120ml, 1.44mol), the mixture was heated to 90°C, the solid gradually dissolved, continue to heat the reaction 4h, stirring and cooling with ice water, precipitation of white solid, filter, filter cake with distilled water to get white (2-carboxyethyl) phosphine hydrochloride, dried, weighing 61.3g, yield 82.4%
General Description
Tris (2-carboxyethyl) phosphine (TCEP) is very effective in cleaving disulfide bonds in aqueous solution. It dissolves in water and is odorless, unlike other trialkylphosphines (tributylphosphine). It is also less toxic than 2-mercaptoethanol. These advantages make it better than the other reducing agents.
Reactivity Profile
Nucleophilic Substitution by the Phosphorus Atom of TCEP. 1. The phosphorus atom attacks one sulfur atom along the S-S bond. 2. A thioalkoxyphosphonium cation and a sulfhydryl anion are formed. 3. A rapid hydrolysis releases the second sulfhydryl molecule and the phosphine oxide. There are two main steps in the breaking of disulfide bridges and forming a free sulfhydryl using TCEP: cleavage of the S-S bond; oxidation of the phosphine and release of sulfhydryl.
storage
Following reconstitution, aliquot and freeze (-20°C). TCEP retains stability when stored at an acidic or alkaline pH; avoid storage at pH 7.0-8.0. Also avoid exposure to high concentrations of phosphate ions (>150 mM). Stock solutions are stable for up to 3 months at -20°C.
Tris(2-carboxyethyl)phosphine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Aptus Therapeutics | +91-9966349855 +91-9966349855 | Telangana, India | 19 | 58 | Inquiry |
| CHEMAZON LABORATORIES | +91 9848551964 | Hyderabad, India | 1320 | 58 | Inquiry |
| Innovassynth Technologies (I) Ltd. | +91-2192260100 +91-7208872197 | Maharashtra, India | 118 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Novaphene Specialities Pvt. Ltd | 91-22-28488599 | Maharashtra, India | 70 | 58 | Inquiry |
| Oceanic Pharmachem Pvt., Ltd. (OPPL) | 91-22-42128600 | Maharashtra, India | 947 | 58 | Inquiry |
| Anand Agencies | 91-20-24454597 | Maharashtra, India | 2337 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Aptus Therapeutics | 58 |
| CHEMAZON LABORATORIES | 58 |
| Innovassynth Technologies (I) Ltd. | 58 |
| Triveni chemicals | 58 |
| Clearsynth Labs | 58 |
| Novaphene Specialities Pvt. Ltd | 58 |
| Oceanic Pharmachem Pvt., Ltd. (OPPL) | 58 |
| Anand Agencies | 58 |
| CHEMSWORTH | 30 |
| A.J Chemicals | 58 |
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