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tert-Butyl diethylphosphonoacetate

CAS No.: 27784-76-5

Chemical Name:: tert-Butyl diethylphosphonoacetate

Synonyms: tert-butyl 2-(diethoxyphosphoryl)acetate;tert-Butyl diethylph;DIETHYL (BOC-METHYL)PHOSPHONATE;T-BUTYL DIETHYL PHOSPHONOACETATE;Tert-buty diethylphosphonoacetate;tert-Butyl diethylphosponoacetate;Tert-butyl diethylphosphonoactate;TERT-BUTYL DIETHYLPHOSPHONOACETATE;Tert-butyl diehylphosphonoacetate;Tert-butyl diethyl phosphonylacetate

CBNumber:: CB5708211

Molecular Formula:: C10H21O5P

Molecular Weight:: 252.24

MOL File:: 27784-76-5.mol

MSDS File:: SDS

Modify Date:: 2024/1/23 13:05:57

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tert-Butyl diethylphosphonoacetate Properties

Boiling point	100-103 °C/1.5 mmHg (lit.)
Density	1.074 g/mL at 25 °C (lit.)
refractive index	n20/D 1.431(lit.)
Flash point	>230 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly)
form	Liquid
Specific Gravity	1.074
color	Clear colorless
Water Solubility	Not miscible or difficult to mix in water.
BRN	2050126
InChI	InChI=1S/C10H21O5P/c1-6-13-16(12,14-7-2)8-9(11)15-10(3,4)5/h6-8H2,1-5H3
InChIKey	NFEGNISFSSLEGU-UHFFFAOYSA-N
SMILES	C(OC(C)(C)C)(=O)CP(OCC)(OCC)=O
CAS DataBase Reference	27784-76-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P280a-P305+P351+P338-P321-P332+P313-P337+P313

Risk Statements

36/38

Safety Statements

26-36-24/25

WGK Germany

HS Code

29319090

NFPA 704

	1
2		1

tert-Butyl diethylphosphonoacetate price More Price(3)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	348333	tert-Butyl diethylphosphonoacetate 95%	27784-76-5	5G	₹5840	2022-06-14	Buy
TCI Chemicals (India)	B2814	tert-Butyl Diethylphosphonoacetate min. 97.0 %	27784-76-5	1G	₹1600	2022-05-26	Buy
TCI Chemicals (India)	B2814	tert-Butyl Diethylphosphonoacetate min. 97.0 %	27784-76-5	5G	₹4600	2022-05-26	Buy

Product number	Packaging	Price	Buy
348333	5G	₹5840	Buy
B2814	1G	₹1600	Buy
B2814	5G	₹4600	Buy

tert-Butyl diethylphosphonoacetate Chemical Properties,Uses,Production

Chemical Properties

Clear colorless liquid

Uses

tert-Butyl diethylphosphonoacetate is used as a reactant for preparation of hydroxymethylated dihydroxyvitamin D3 analogs via Wittig-Horner approach, as potential antitumor agents, synthesis of phosphopeptide mimetic prodrugs targeted to Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 (Stat 3) and bicyclic triaminophosphine-promoted stereoselective synthesis of a,?-unsaturated esters, fluorides, and nitriles from aldehydes and ketones using Wadsworth-Emmons phosphonates

Synthesis

Triethyl phosphite (485 g) is warmed up to 90°C under N2 atmosphere in a three-necked round-bottomed flask, and /-butyl bromoacetate (541 g) is added dropwise into the system within 2 h. Then, the mixture is stirred at 90°C for around 4 hours and cooled to room temperature. The obtained mixture is distilled under vacuo to remove compounds with low boiling points, and the residue is collected as a colorless liquid tert-butyl diethylphosphonoacetate in 97 percent yield (680 g).

tert-Butyl diethylphosphonoacetate Preparation Products And Raw materials

Raw materials

Preparation Products

Methyl diethylphosphonoacetate (E)-tert-butyl 3-(4-cyanophenyl)acrylate TERT-BUTYL (3S)-3-AMINO-5-METHYLHEXANOATE, 97

tert-Butyl diethylphosphonoacetate Suppliers

Global( 290)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CHEMSWORTH	+91-261-2397244	New Delhi, India	6707	30	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Reax Chemicals	08048372701Ext 416	Hyderabad, India	4223	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
Alfa Aesar	1 800 209 7001	Maharashtra, India	6913	58	Inquiry
Jiangxi Sunway Chemical Co., Ltd.	+86-0794-5259909 +8615888611133	China	22	58	Inquiry
Jiangxi Sunway Chemical Co., Ltd.	+86-0794-5259909 +8615888611133	China	22	58	Inquiry
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	China	985	58	Inquiry
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	China	16209	58	Inquiry

Supplier	Advantage
CHEMSWORTH	30
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
Reax Chemicals	58
TCI Chemicals (India) Pvt. Ltd.	58
Alfa Aesar	58
Jiangxi Sunway Chemical Co., Ltd.	58
Jiangxi Sunway Chemical Co., Ltd.	58
Hangzhou ICH Biofarm Co., Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58

tert-Butyl diethylphosphonoacetate Spectrum

tert-Butyl diethylphosphonoacetate(27784-76-5)¹HNMR tert-Butyl diethylphosphonoacetate(27784-76-5)IR tert-Butyl diethylphosphonoacetate(27784-76-5)Raman

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DIETHYL(2-TERT-BUTOXYCARBONYLMETHYL)PHOSPHONATE (DIETHOXYPHOSPHORYL)ACETIC ACID TERT-BUTYL ESTER DIETHYL (BOC-METHYL)PHOSPHONATE DIETHYLPHOSPHONOACETIC ACID TERT-BUTYL ESTER DIETHYL (TERT-BUTOXYCARBONYLMETHYL)PHOSPHONATE T-BUTYL DIETHYL PHOSPHONOACETATE TERT-BUTYL DIETHYLPHOSPHONOACETATE tert-Butyl diethylphosphonoacetate, 98 % Tert-Butyl p,p-diethylphosphonoacetate ACETIC ACID, 2-(DIETHOXYPHOSPHINYL)-, 1,1-DIMETHYLETHYL ESTER Tert-buty diethylphosphonoacetate tert-Butyl diethylphosphonoacetate,95% Tert-butyl diehylphosphonoacetate tert-Butyl diethylph (Diethoxyphosphinyl)acetic acid 1,1-dimethylethyl ester Diethyl tert-butoxycarbonylmethanephosphonate tert-Butyl (diethoxyphosphinyl)acetate tert-Butyl diethylphosphonoacetate Diethyl (Boc-methyl)phosphonate Diethyl (tert-Butoxycarbonylmethyl)phosphonate Diethylphosphonoacetic Acid tert-Butyl Ester 3-[(2-methylpropan-2-yl)oxy-oxomethyl]pentan-3-ylphosphonic acid Diethyl(2-tert-butoxycarbonylmethyl)phosphonate 98% tert-Butyl diethylphosponoacetate Tert-butyl diethylphosphonoactate tert-Butyl Diethylphosphonoacetate > Tert-butyl diethyl phosphonylacetate TERT-BUTYL DIETHYLPHOSPHONOACETATE (27784-76-5) tert-butyl 2-(diethoxyphosphoryl)acetate 1,1-Dimethylethyl 2-(diethoxyphosphinyl)acetate ert-butyl2-diethoxyphosphorylacetate Diethyl phosphonoyl acetate tert butyl ester 27784-76-5 C2H5O2POCH2CO2CCH33 Horner-Wadsworth-Emmons Reagents Olefination Synthetic Reagents C-C Bond Formation C-C Bond Formation Horner-Wadsworth-Emmons Reagents Olefination 27784-76-5