diloxanide
- CAS No.
- 579-38-4
- Chemical Name:
- diloxanide
- Synonyms
- RD3803;RD 3803;RD-3803;Diloxanid;diloxanide;Diloxanida;diloxanide USP/EP/BP;α,α-Dichloro-4'-hydroxy-N-methylacetanilide;2,2-dichloro-N-(4-hydroxyphenyl)-N-methylacetamide;2,2-dichloro-N-(4-hydroxyphenyl)-N-methyl-acetamide
- CBNumber:
- CB5875447
- Molecular Formula:
- C9H9Cl2NO2
- Molecular Weight:
- 234.08
- MOL File:
- 579-38-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:12
diloxanide Chemical Properties,Uses,Production
Uses
Diloxanide is also active against cysts and trophozoites localized in the lumen of the intestine, and it is used for treating the carrier E. histolytica, as well as for treating asymptomatic or moderate forms of amebiasis. In the transition stage to trophozoites, the drug is less active than iodoquinol. A synonym of this drug is furamide.
Antimicrobial activity
Diloxanide inhibits E. histolytica with unusually high specificity at concentrations of 0.01–0.1 mg/L.
Acquired resistance
No resistance has been reported. Patients with dysentery have lower cure rates than cyst excreters.
Pharmaceutical Applications
Dichloro(hydroxyphenyl)methylacetamide. Available as an insoluble ester, the furoate, for oral administration.
Pharmacokinetics
Human pharmacokinetic data are limited. Animal data show that diloxanide furoate is rapidly absorbed from the intestine. The furoate is hydrolyzed in the gut, leaving high intraluminal concentrations of free diloxanide. About 75% is excreted via the kidney within 48 h, mostly as a glucuronide.
Clinical Use
Furamide, or eutamide, is the 2-furoate ester of 2,2-dichloro-4 -hydroxy-N-methylacetanilide. It was developed as a resultof the discovery that various α,α-dichloroacetamidespossessed amebicidal activity in vitro. Diloxanide itself andmany of its esters are also active, and drug metabolism studiesindicate that hydrolysis of the amide is required for theamebicidal effect. Nonpolar esters of diloxanide are morepotent than polar ones. Diloxanide furoate has been used inthe treatment of asymptomatic carriers of E. histolytica. Itseffectiveness against acute intestinal amebiasis or hepaticabscesses, however, has not been established. Diloxanidefuroate is a white crystalline powder. It is administered orallyonly as 500-mg tablets and may be obtained in the UnitedStates from the CDC in Atlanta, Georgia.
Side effects
It is well tolerated, but flatulence is common, and nausea and vomiting may occur.
diloxanide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | China | 23556 | 58 | Inquiry |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | China | 9003 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |
| BOC Sciences | USA | 0 | 65 | Inquiry | |
| Guangzhou Yunmen Biotechnology Co., Ltd | 18902340307 18902340307 | China | 9246 | 58 | Inquiry |
| Chengtian Fine Chemical Co., Ltd | 18164098996 | China | 6684 | 58 | Inquiry |
| Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 15229059051 | China | 9968 | 58 | Inquiry |
| Shanghai Gukang Biotechnology Co., LTD | 021-34080528 13564510648 | China | 123 | 58 | Inquiry |
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