Diloxanide furoate
- CAS No.
- 3736-81-0
- Chemical Name:
- Diloxanide furoate
- Synonyms
- 8073cb;Furoate;furamide;amebiazol;furentomin;histomibal;diclofurazol;dichlofurazol;entamidefuroate;diloxanidfuroate
- CBNumber:
- CB4723149
- Molecular Formula:
- C14H11Cl2NO4
- Molecular Weight:
- 328.15
- MOL File:
- 3736-81-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/14 20:44:35
| Melting point | 111-114 °C |
|---|---|
| Boiling point | 438.4±45.0 °C(Predicted) |
| Density | 1.424±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | -0?+-.0.50(Predicted) |
| color | Off-White to Light Beige |
| BCS Class | 4 |
| CAS DataBase Reference | 3736-81-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301+P312+P330 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 36 |
| WGK Germany | 3 |
| RTECS | LV1821800 |
| HS Code | 2924296000 |
| Toxicity | mouse,LDLo,oral,710mg/kg (710mg/kg),Archives of Environmental Contamination and Toxicology. Vol. 14, Pg. 111, 1985. |
Diloxanide furoate Chemical Properties,Uses,Production
Uses
selective agonist for delta-opioid receptor
Indications
Diloxanide furoate (Furamide) is an amebicide that is effective against trophozoites in the intestinal tract. In mild or asymptomatic infections, cures of 83 to 95% have been achieved; in patients with dysentery, cure rates may be less impressive. The drug is administered only orally and is rapidly absorbed from the gastrointestinal tract following hydrolysis of the ester group. It is remarkably free of side effects, but occasionally flatulence, abdominal distention, anorexia, nausea, vomiting, diarrhea, pruritus, and urticaria occur. Diloxanide is excreted in the urine, largely as the glucuronide. It is not available in the United States.
Clinical Use
Diloxanide furoate (available from the Centers for Disease Control and Prevention [CDC]) is prescribed for the treatment of asymptomatic amebiasis but is ineffective as a single agent for the extraintestinal form of the disease. The drug is administered orally and is hydrolyzed in the gut to give diloxanide, which is considered to be the active drug. Diloxanide is the only form identified in the bloodstream. The drug is found in the urine as the glucuronide.
Diloxanide furoate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Heer Pharma Pvt Ltd | +91-9820051881 +91-9820051881 | Maharashtra, India | 102 | 58 | Inquiry |
| Smruthi Organics Limited | +91-9881467770 +91-9822910599 | Maharashtra, India | 24 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| SETV ASRV LLP | +91-9731133411 +91-9731133411 | Telangana, India | 531 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Triveni Interchem Private Limited (Group Of Triveni... | 08046042087 | Gujarat, India | 497 | 58 | Inquiry |
| Sonachi Industries Ltd | 09870760066 | Mumbai, India | 2 | 58 | Inquiry |
| Global Pharma | 08048372772Ext 809 | Mumbai, India | 70 | 58 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |