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STATIL

STATIL Structure
CAS No.
72702-95-5
Chemical Name:
STATIL
Synonyms
STATIL;MK-538;ICI-plc;ICI-128436;Ponalrestat;Ponalrestat (MK-538;[3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID;Ponalrestat Statil;3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID (STATIL);2-(3-(4-broMo-2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)acetic acid
CBNumber:
CB6193847
Molecular Formula:
C17H12BrFN2O3
Molecular Weight:
391.19
MOL File:
72702-95-5.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:13
Request For Quotation

STATIL Properties

Melting point 184-186℃ (DEC.)
Density 1.60
storage temp. Store at RT
solubility DMF: 2 mg/mL; DMSO: 2 mg/mL; Ethanol: 2 mg/mL; PBS (pH 7.2): 0.2 mg/mL
form A crystalline solid
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Risk Statements  36/37/38
Safety Statements  26-36/37/39

STATIL Chemical Properties,Uses,Production

Description

Statil is an aldose reductase inhibitor that blocks the conversion of glucose to sorbitol. It demonstrates selectivity for aldose reductase 2 over aldose reductase 1 with Ki values of 7.7 nM and 60 μM, respectively. Statil has been shown to prevent diabetes-induced alterations of the cardiovascular system in 14-day streptozotocin-diabetic rats. Aldose reductase inhibition by statil has also been used to impair the synthesis of prostaglandin F2α by human cultured preadipocytes.

Uses

Statil is a knon aldose reductase inhibitor which blocks the conversion of glucose to sorbitol. In addition it suppresses cell cancer growth

Biological Activity

Potent aldose reductase inhibitor.

STATIL Preparation Products And Raw materials

Raw materials

4-Bromo-2-fluorobenzyl bromide (4-OXO-3,4-DIHYDRO-PHTHALAZIN-1-YL)-ACETIC ACID ETHYL ESTER

Preparation Products

STATIL Suppliers

Global( 82)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Hangzhou MolCore BioPharmatech Co.,Ltd. +86-057181025280; +8617767106207 China 49739 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
Shanghai Acmec Biochemical Technology Co., Ltd. +undefined18621343501 China 33350 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
Supplier Advantage
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
CONIER CHEM AND PHARMA LIMITED 58
career henan chemical co 58
TargetMol Chemicals Inc. 58
InvivoChem 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
Shanghai Acmec Biochemical Technology Co., Ltd. 58
Aladdin Scientific 58

72702-95-5(STATIL)Related Search:

STATIL BENZYL-(2-FLUORO-BENZYL)-AMINE 4-BROMO-2-FLUOROBENZYLAMINE 1,1-Dibenzylhydrazine (4-BROMOBENZYL)METHYLAMINE
(2-FLUORO-BENZYL)-HYDRAZINE (3-METHYL-4-OXO-3,4-DIHYDRO-PHTHALAZIN-1-YL)-ACETIC ACID (4-OXO-3,4-DIHYDROPHTHALAZIN-1-YL)ACETIC ACID 3-(2-FORMYLPHENYL)PROPANOIC ACID CHEMBRDG-BB 5937785
4-BROMO-BENZYL-HYDRAZINE 4-Bromo-2-fluorotoluene 4-ETHYL-2H-PHTHALAZIN-1-ONE
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3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID (STATIL) 3-[(4-Bromo-2-fluorophenyl)methyl]-3,4-dihydro-4-oxo-1-phthalazineacetic acid ICI-128436 ICI-plc MK-538 2-(3-(4-broMo-2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)acetic acid Ponalrestat Statil STATIL [3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID Ponalrestat Ponalrestat (MK-538 ICI128436,ICI 128436,glucose,ALR,AKR1B1,Ponalrestat,Inhibitor,Aldose Reductase,conversion,inhibit,sorbitol,ICI-128436,orally,noncompetitive,ALR2,ALR1 72702-95-5 C17H12BrFN2O3 Inhibitors