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Lomitapide

Lomitapide Structure
CAS No.
182431-12-5
Chemical Name:
Lomitapide
Synonyms
AEGR 733;BMS 201038;LoMitapide;BMS 201238;BMS 201038-01;AEGR733, BMS201038;AEGR-733(Lomitapide);CB62485047,loMitapide;Lomitapide (10mM in DMSO);AEGR-733(Lomitapide)free base
CBNumber:
CB62485047
Molecular Formula:
C39H37F6N3O2
Molecular Weight:
693.72
MOL File:
182431-12-5.mol
MSDS File:
SDS
Modify Date:
2023/6/8 17:06:36
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Lomitapide Properties

Melting point 142°C(lit.)
Boiling point 778.2±60.0 °C(Predicted)
Density 1.34±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
pka 12.66±0.20(Predicted)
form powder
color white to beige

SAFETY

Risk and Safety Statements

HS Code  2933.39.4100

Lomitapide price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML1385 Lomitapide ≥98% (HPLC) 182431-12-5 5MG ₹17211.75 2022-06-14 Buy
Sigma-Aldrich(India) SML1385 Lomitapide ≥98% (HPLC) 182431-12-5 25MG ₹69886.2 2022-06-14 Buy
TCI Chemicals (India) L0298 Lomitapide 182431-12-5 25MG ₹7500 2022-05-26 Buy
TCI Chemicals (India) L0298 Lomitapide 182431-12-5 100MG ₹14500 2022-05-26 Buy
Product number Packaging Price Buy
SML1385 5MG ₹17211.75 Buy
SML1385 25MG ₹69886.2 Buy
L0298 25MG ₹7500 Buy
L0298 100MG ₹14500 Buy

Lomitapide Chemical Properties,Uses,Production

Description

Lomitapide was approved by the US FDA in December 2012 for the treatment of patients with familial hypercholesteremia (referred to as HoFH) in conjunction with a low-fat diet andother lipid-lowering treatments. Lomitapide was discovered from a high-through put screen that identified several structurally distinct MTP inhibitors. Combination of key structural features from two structurally distinct HTS hits provided potent MTP inhibitors. Parallel analog synthesis led to lomitapide as an optimized structure. Lomitapide was synthesized via alkylation of 9-fluorenylcarboxylic acid with 1,4-dibromobutane which, after trifluoroethylamide formation, provided a bromide intermediate that was displaced by Boc-4-aminopiperidine. Introduction of the 4'-trifluoromethylbiphenylcarboxamide gave lomitapide, which was found to inhibit MTP with an IC50 of 0.5 nM and to exhibit good cholesterol-lowering efficacy in Sprague–Dawley rats (intravenous and oral ED50～0.2 mg/kg).

Uses

Lomitapide has been used as a microsomal triglyceride transfer protein (MTP) inhibitor to study its effects on very-low-density lipoproteins (VLDL) export in mouse hepatocytes.

Lomitapide Preparation Products And Raw materials

Raw materials

Preparation Products

Lomitapide Suppliers

Global( 135)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Varanous Labs Pvt Ltd +91-7036248882 +91-7036248882 Hyderabad, India 1541 58 Inquiry
Glenmark Pharmaceuticals Limited +912240189999 Maharashtra, India 93 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32836 60 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49392 58 Inquiry
Finetech Industry Limited +86-27-87465837 +8618971612321 China 9640 58 Inquiry
sgtlifesciences pvt ltd +8617013299288 China 12382 58 Inquiry
Supplier Advantage
Varanous Labs Pvt Ltd 58
Glenmark Pharmaceuticals Limited 58
CLEARSYNTH LABS LTD. 58
TCI Chemicals (India) Pvt. Ltd. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
ATK CHEMICAL COMPANY LIMITED 60
BOC Sciences 58
CONIER CHEM AND PHARMA LIMITED 58
Finetech Industry Limited 58
sgtlifesciences pvt ltd 58

Lomitapide Spectrum

N-(2,2,2-Trifluoroethyl)-9-(4-[4-[4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamido]piperidin-1-yl]butyl)-9H-fluorene-9-carboxamide(182431-12-5)1HNMR

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N-(2,2,2-Trifluoroethyl)-9-(4-[4-[4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamido]piperidin-1-yl]butyl)-9H-fluorene-9-carboxamide N-(2,2,2-trifluoroethyl)-9-[4-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-9H-fluorene-9-carboxamide AEGR 733 BMS 201038 BMS 201038-01 BMS 201238 LoMitapide N-(2,2,2-trifluoroethyl)-9-(4-(4-(4'-(trifluoroMethyl)biphenyl-2-ylcarboxaMido)piperidin-1-yl)butyl)-9H-fluorene-9-carboxaMide CB62485047,loMitapide AEGR-733(Lomitapide)free base AEGR-733; BMS-201038; AEGR733; BMS201038; AEGR 733; BMS 201038; AEGR-733(Lomitapide) AEGR733, BMS201038 9H-Fluorene-9-carboxamide, N-(2,2,2-trifluoroethyl)-9-[4-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]- N-(2,2,2-Trifluoroethyl)-9-[4-[4-[4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido]piperidin-1-yl]butyl]-9H-fluorene-9-carboxamide Lomitapide (10mM in DMSO) N-(2,2,2-Trifluoroethyl)-9-(4-[4-[4'-(trifluoromethyl)[1,1'-... Lomitapide D8Q: What is Lomitapide D8 Q: What is the CAS Number of Lomitapide D8 Q: What is the storage condition of Lomitapide D8 N-(2,2,2-Trifluoroethyl)-9-(4-[4-[4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamido]piperidin-1-yl]butyl)-9H-fluorene-9-carboxamide N-(2,2,2-trifluoroethyl)-9-[4-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]piperidin-1-yl]butyl]fluorene-9-carboxamide 182431-12-5 C39H37F6N3O2 Inhibitors