Lomitapide
![Lomitapide Structure](CAS/20180808/GIF/182431-12-5.gif)
- CAS No.
- 182431-12-5
- Chemical Name:
- Lomitapide
- Synonyms
- AEGR 733;BMS 201038;LoMitapide;BMS 201238;BMS 201038-01;AEGR733, BMS201038;AEGR-733(Lomitapide);CB62485047,loMitapide;Lomitapide (10mM in DMSO);AEGR-733(Lomitapide)free base
- CBNumber:
- CB62485047
- Molecular Formula:
- C39H37F6N3O2
- Molecular Weight:
- 693.72
- MOL File:
- 182431-12-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 17:06:36
Lomitapide price More Price(4)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | SML1385 | Lomitapide ≥98% (HPLC) | 182431-12-5 | 5MG | ₹17211.75 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | SML1385 | Lomitapide ≥98% (HPLC) | 182431-12-5 | 25MG | ₹69886.2 | 2022-06-14 | Buy |
TCI Chemicals (India) | L0298 | Lomitapide | 182431-12-5 | 25MG | ₹7500 | 2022-05-26 | Buy |
TCI Chemicals (India) | L0298 | Lomitapide | 182431-12-5 | 100MG | ₹14500 | 2022-05-26 | Buy |
Lomitapide Chemical Properties,Uses,Production
Description
Lomitapide was approved by the US FDA in December 2012 for the treatment of patients with familial hypercholesteremia (referred to as HoFH) in conjunction with a low-fat diet andother lipid-lowering treatments. Lomitapide was discovered from a high-through put screen that identified several structurally distinct MTP inhibitors. Combination of key structural features from two structurally distinct HTS hits provided potent MTP inhibitors. Parallel analog synthesis led to lomitapide as an optimized structure. Lomitapide was synthesized via alkylation of 9-fluorenylcarboxylic acid with 1,4-dibromobutane which, after trifluoroethylamide formation, provided a bromide intermediate that was displaced by Boc-4-aminopiperidine. Introduction of the 4'-trifluoromethylbiphenylcarboxamide gave lomitapide, which was found to inhibit MTP with an IC50 of 0.5 nM and to exhibit good cholesterol-lowering efficacy in Sprague–Dawley rats (intravenous and oral ED50~0.2 mg/kg).
Uses
Lomitapide has been used as a microsomal triglyceride transfer protein (MTP) inhibitor to study its effects on very-low-density lipoproteins (VLDL) export in mouse hepatocytes.
Lomitapide Preparation Products And Raw materials
Raw materials
Preparation Products
Lomitapide Suppliers
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
Varanous Labs Pvt Ltd | +91-7036248882 +91-7036248882 | Hyderabad, India | 1541 | 58 | Inquiry |
Glenmark Pharmaceuticals Limited | +912240189999 | Maharashtra, India | 93 | 58 | Inquiry |
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32836 | 60 | Inquiry |
BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49392 | 58 | Inquiry |
Finetech Industry Limited | +86-27-87465837 +8618971612321 | China | 9640 | 58 | Inquiry |
sgtlifesciences pvt ltd | +8617013299288 | China | 12382 | 58 | Inquiry |