5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide

CAS No.: 511296-88-1

Chemical Name:: 5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide

Synonyms: PFT-β;CS-1771;HY-16702A;Pifithrin B;Pifithrin-β;Cyclic PFT-α;Cyclic PFT-α;Pifithrin-beta;Cyclic Pifithrin-α;Pifithrin-β(PPT-β)

CBNumber:: CB62518925

Molecular Formula:: C16H16N2S.HBr

Molecular Weight:: 349

MOL File:: 511296-88-1.mol

MSDS File:: SDS

Modify Date:: 2023/9/4 16:42:00

Request For Quotation

5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide Properties

storage temp.	-20°C
solubility	DMSO: soluble20mg/mL
form	powder to crystal
color	White to Almost white
Merck	14,7421

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
WGK Germany	3
HS Code	2934.99.4400

5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide price More Price(4)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	P4236	Cyclic Pifithrin-α hydrobromide ≥98% (HPLC)	511296-88-1	5MG	₹17038.55	2022-06-14	Buy
Sigma-Aldrich(India)	P4236	Cyclic Pifithrin-α hydrobromide ≥98% (HPLC)	511296-88-1	10MG	₹28415.63	2022-06-14	Buy
TCI Chemicals (India)	C2826	Cyclic Pifithrin-α Hydrobromide	511296-88-1	20MG	₹8500	2022-05-26	Buy
TCI Chemicals (India)	C2826	Cyclic Pifithrin-α Hydrobromide	511296-88-1	100MG	₹30000	2022-05-26	Buy

Product number	Packaging	Price	Buy
P4236	5MG	₹17038.55	Buy
P4236	10MG	₹28415.63	Buy
C2826	20MG	₹8500	Buy
C2826	100MG	₹30000	Buy

5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide Chemical Properties,Uses,Production

Description

Pifithrin-α (PFT-α; ) is a reversible inhibitor of p53-dependent transcription and apoptosis. Cyclic PFT-α, also known as PFT-β, is a stable analog of PFT-α, formed by the condensation of pifithrin-α in solution. It inhibits the growth of the cancer cell lines IGROV-1, A2780, and HCT116 (IC₅₀ = 23, 77, and 103 μM, respectively). At doses lower than those that inhibit growth, cyclic PFT-α induces autophagy in HCT116 cells and sensitizes IGROV-1 and H460 cells to anti-microtubule agents. In addition, 10 μM cyclic PFT-α blocks p53-dependent protection from DNA damage, induced by hydrogen peroxide or ultraviolet radiation, in melanocytes.

Uses

Cyclic Pifithrin-α hydrobromide has been used as p53 inhibitor to study its role in cigarette smoke?induced apoptosis of pulmonary endothelial cells.

Biochem/physiol Actions

A stable analog of Pifithrin-α (Product Code P4359) with similar biological activities and lower cellular toxicity.

5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide Preparation Products And Raw materials

Raw materials

Preparation Products

5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide Suppliers

Global( 93)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29826	58	Inquiry
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 15319487004	China	4088	58	Inquiry
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	China	5738	58	Inquiry
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	China	52861	58	Inquiry
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10522	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
TCI Chemicals (India) Pvt. Ltd.	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Shaanxi Dideu Medichem Co. Ltd	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58

5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide Spectrum

5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide(511296-88-1)MS 5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide(511296-88-1)¹HNMR

511296-88-1(5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide)Related Search:

2-(3,4-DICHLOROPHENYL)-N-METHYL-N-[(1S)-1-PHENYL-2-(1-PYRROLIDINYL)ETHYL]ACETAMIDE HYDROCHLORIDE Citalopram hydrobromide Ascorbic Acid

5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide Cyclic Pifithrin-α hydrobromide Pifithrin-beta Cyclic Pifithrin-alpha HydrobroMide 5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide Pifithrin-β 2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole hydrobromide Cyclic PFT-α hydrobromide Pifithrin-α, cyclic Cyclic Pifithrin-α HBr Pifithrin- beta hydrobromide Cyclic PFT-α Pifithrin B PIFITHRIN-Β;PIFITHRIN B;CYCLIC PFT-Α; PIFITHRIN-Β; PFT-Β CS-1771 CYCLIC PIFITHRIN-Α HYDROBROMIDE;CYCLIC PFT-Α HYDROBROMIDE;PFT-Β HYDROBROMIDE HY-16702A Cyclic Pifithrin-α Hydrobromide > Pifithrin-β Cyclic Pifithrin-α 2-(p-Tolyl)-5,6,7,8-tetrahydroimidazo[2,1-b]benzothiazole Hydrobromide Pifithrin-α, Cyclic, hydrobromide Pifithrin-β hydrobromide Pifithrin-β HBr (QB102 Cyclic Pifithrin-α Hydrobromide Cyclic PFT-α PFT β (hydrobromide) PFT-β 2-(p-Tolyl)-5,6,7,8-tetrahydrobenzo[d]imidazo[2,1-b]thiazole hydrobromide Imidazo[2,1-b]benzothiazole, 5,6,7,8-tetrahydro-2-(4-methylphenyl)-, hydrobromide (1:1) 5,6,7,8-tetrahydro-2-(4-methylphenyl)-Imidazo[2,1-b]benzothiazole hydrobromide (1:1) inhibit,MDM-2/p53,Pifithrinβ hydrobromide,Ferroptosis,Pifithrin β hydrobromide,Cyclic Pifithrin-α,Inhibitor,PFT β Pifithrin-β(PPT-β) 511296-88-1 C16H16N2SHBr C16H16N2SBrH