Mefloquine hydrochloride
- CAS No.
- 51773-92-3
- Chemical Name:
- Mefloquine hydrochloride
- Synonyms
- Loriam;wr14249;wr142490;MEFLOQUINE HCL;Ro 21-5998/001;s*)-(r(+-)-lorid;Mefloquin hydrochloride;efloquine hydrochloride;MEFLOQUINE HYDROCHLORIDE;MefloquineHydrochloride>
- CBNumber:
- CB6252498
- Molecular Formula:
- C17H17ClF6N2O
- Molecular Weight:
- 414.77
- MOL File:
- 51773-92-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/12/14 15:42:45
| Melting point | 250-254?C |
|---|---|
| storage temp. | 2-8°C |
| solubility | DMSO: 38 mg/mL, soluble |
| form | solid |
| color | white |
| λmax | 222nm(Acidic H2O)(lit.) |
| Merck | 14,5801 |
| BCS Class | 4/2 |
| Stability | Temperature Sensitive |
| InChI | InChI=1/C17H16F6N2O.ClH/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;/h3-5,8,12,15,24,26H,1-2,6-7H2;1H/t12-,15+;/s3 |
| InChIKey | WESWYMRNZNDGBX-YLCXCWDSSA-N |
| SMILES | C12N=C(C=C([C@@H](O)[C@@]3([H])NCCCC3)C=1C=CC=C2C(F)(F)F)C(F)(F)F.Cl |&1:5,7,r| |
| CAS DataBase Reference | 51773-92-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | VC0308000 | |||||||||
| HS Code | 2933399090 | |||||||||
| NFPA 704 |
|
Mefloquine hydrochloride price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR1705 | Mefloquine Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | 51773-92-3 | 1G | ₹10446.13 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M2319 | Mefloquine hydrochloride ≥98% (HPLC), powder | 51773-92-3 | 100MG | ₹16908.65 | 2022-06-14 | Buy |
| TCI Chemicals (India) | M2313 | Mefloquine Hydrochloride | 51773-92-3 | 1G | ₹9100 | 2022-05-26 | Buy |
Mefloquine hydrochloride Chemical Properties,Uses,Production
Description
Mefloquine hydrochloride is an erythrocytic schizonticide useful, in combination with sulfadoxine and pyrimethamine, in the prophylaxis and treatment of malaria. Administered once weekly, the combination is effective against pathogens resistant to other agents.
Chemical Properties
White Solid
Uses
Mefloquine Hydrochloride (Polymorph Form E) is a polymorphic form of Mefloquine Hydrochloride (M207055), a quinoline methanol antimalarial agent.
General Description
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards
Clinical Use
The newest of the 4-aminoquinolines,mefloquine, is marketed as the R,S-isomer. It was developedin the 1960s as part of the U.S. Army’s WalterReed Institute for Medical Research antimalarial researchprogram. It differs significantly from the other agents in this class by having two trifluromethyl moieties at positions2’ and 8' and no electronegative substituents at eitherpositions 6' (quinine) or 7' (chloroquine). Mefloquine alsodiffers from chloroquine and its analogs by being a schizonticide acting before the parasite canenter the erythrocyte. There is some evidence that it acts byraising the pH in the parasite’s vesicles interfering with itsability to process heme. Mefloquine-resistant strains ofP. falciparum have appeared. Relapse can occur with acuteP. vivax that has been treated with mefloquine because thedrug does not eliminate the hepatic phase of this species,which can reinfect the liver.
Mefloquine is teratogenic in rats, mice, and rabbits. Thereis an FDA-required warning that this drug can cause exacerbatemental disorders and is contraindicated in patients withactive depression, a recent history of depression, generalizedanxiety disorder, psychosis, schizophrenia, and other majorpsychiatric disorders or a history of convulsions.
Mefloquine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ANWITA APIS | +919000311012 | Hyderabad, India | 198 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Eisai Pharmaceuticals India Private Limited | 08069013892Ext 812 | Andhra Pradesh, India | 11 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Manus Aktteva Biopharma LLP | 08048250218Ext 800 | Ahmedabad, India | 655 | 58 | Inquiry |
| Festiva Pharma | 08048372775Ext 728 | Gujarat, India | 238 | 58 | Inquiry |
| Hritik Chemicals Pvt., Ltd. | 91-22-26313359 | Maharashtra, India | 88 | 58 | Inquiry |
| Jigs chemical | +91 (79) 26402695/26401498 | Gujarat, India | 319 | 58 | Inquiry |