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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Metabolism >P450 (e.g. CYP17) inhibitor >Cobicistat

Cobicistat

Cobicistat Structure
CAS No.
1004316-88-4
Chemical Name:
Cobicistat
Synonyms
Tybost;Cobicistat (GS-9350);GS9350;CS-753;GS-9350;GS 9350;Genvoya.;Cobicistat;Cobiclstat;Cobicistat D8
CBNumber:
CB62627692
Molecular Formula:
C40H53N7O5S2
Molecular Weight:
776.02
MOL File:
1004316-88-4.mol
Modify Date:
2023/5/18 11:31:04
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Cobicistat Properties

Melting point 50-54°C
Boiling point 974.5±65.0 °C(Predicted)
Density 1.228±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. Hygroscopic, Refrigerator, under inert atmosphere
solubility Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form Solid
pka 11.86±0.46(Predicted)
color White to Off-White
Stability Hygroscopic
InChIKey ZCIGNRJZKPOIKD-CQXVEOKZSA-N
SMILES C(OCC1SC=NC=1)(=O)N[C@@H](CC1=CC=CC=C1)CC[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CCN1CCOCC1)NC(=O)N(C)CC1=CSC(C(C)C)=N1

Cobicistat Chemical Properties,Uses,Production

Description

Cobicistat, a selective, mechanism-based CYP3A inhibitor, was discovered and developed by Gilead Sciences, Inc. In 2013, European Medicines Agency (EMA) approved cobicistat (Tybost) for the treatment of HIV-1 infection in combination with protease inhibitors (PIs) atazanavir or darunavir. Interestingly, cobicistat does not interact with HIV directly, but instead serves as a pharmacokinetic enhancer to boost the anti-HIV effect of atazanavir or darunavir through blockade of CYP3A. Cobicistat slows CYP-mediated metabolism of atazanavir and darunavir, resulting in prolonged systemic exposure of the drug(s). Cobicistat is also available as part of a fixed-dose combination tablet (Stribild) of four additional drugs with CYP3A liabilities (elvitegravir, cobicistat, emtricitabine and tenofovir disoproxil fumarate), which was approved in U.S. in 2012, and subsequently approved in Europe and Japan in 2013.

Uses

Cobicistat is a HIV protease inhibitor and have been coadministered with low-dose ritonavir (R535000) as a pharmacoenhancer, significantly increasing their plasma concentrations.

Cobicistat Preparation Products And Raw materials

Raw materials

Preparation Products

Cobicistat Suppliers

Global( 188)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
J S LABS +91-7330612784 +91-7330612784 Tamil Nadu, India 160 58 Inquiry
Honour Lab Limited +919845977466 Telangana, India 164 58 Inquiry
Humble Healthcare Limited +91-9720093000 +91-8006400378 Uttar Pradesh, India 141 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Hangzhou Benoy Chemical Co., Ltd +8617342059697 China 315 58 Inquiry
Alpha Biopharmaceuticals Co., Ltd +86-15542445688 China 888 58 Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21667 55 Inquiry
Supplier Advantage
J S LABS 58
Honour Lab Limited 58
Humble Healthcare Limited 58
Pharma Affiliates 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
SynZeal Research Pvt Ltd 58
CLEARSYNTH LABS LTD. 58
Hangzhou Benoy Chemical Co., Ltd 58
Alpha Biopharmaceuticals Co., Ltd 58
Henan Tianfu Chemical Co.,Ltd. 55

Cobicistat Spectrum

Cobicistat(1004316-88-4)1HNMR

1004316-88-4(Cobicistat)Related Search:

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Afatinib AZD-1208 Olaparib
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(3R,6R,9S)-12-Methyl-13-[2-(1-methylethyl)-4-thiazolyl]-9-[2-(4-morpholinyl)ethyl]-8,11-dioxo-3,6-bis(phenylmethyl)-2,7,10,12-tetraazatridecanoic acid 5-thiazolylmethyl ester Cobicistat thiazol-5-ylMethyl (2R,5R)-5-((S)-2-(3-((2-isopropylthiazol-4-yl)Methyl)-3-Methylureido)-4-MorpholinobutanaMido)-1,6-diphenylhexan-2-ylcarbaMate GS 9350 GS9350 GS-9350 Cobicistat D8 2,7,10,12-Tetraazatridecanoic acid, 12-Methyl-13-[2-(1-Methylethyl)-4-thiazolyl]-9-[2-(4-Morpholinyl)ethyl]-8,11-dioxo-3,6-bis(phenylMethyl)-, 5-thiazolylMethyl ester, (3R,6R,9S)- Cobiclstat Thiazol-5-ylmethyl (2R,5R)-5-((S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-mor Cobicistat, brand name: Tybost Genvoya. GS9350; GS-9350; GS 9350; COBICISTAT, BRAND NAME: TYBOST; GENVOYA. CS-753 GS 9350; GS9350 COBICISTAT 1004316-88-4 Cobicistat USP/EP/BP 1,3-thiazol-5-ylmethyl N-[(2r,5r)-5-[[(2s)-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]-4-morpholin-4-ylbutanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate Cobicistat (10mM in DMSO) CobicistatQ: What is Cobicistat Q: What is the CAS Number of Cobicistat Q: What is the storage condition of Cobicistat Q: What are the applications of Cobicistat Cobicistat D8Q: What is Cobicistat D8 Q: What is the CAS Number of Cobicistat D8 Q: What is the storage condition of Cobicistat D8 Q: What are the applications of Cobicistat D8 C40H53N7O5S2 Cobicistat 1004316-88-4 Tybost Cobicistat (GS-9350) 1004316-88-4 C40H53N7O5S2 Inhibitors Inhibitor