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CHIR-090

CHIR-090 Structure
CAS No.
728865-23-4
Chemical Name:
CHIR-090
Synonyms
CS-2285;CHIR-090;CHIR-090 (CHIR 090;N-((2S,3R)-3-Hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl)-4-((4-(morpholinomethyl)phenyl)ethynyl)benzamide;N-[(1S,2R)-2-Hydroxy-1-[(hydroxyamino)carbonyl]propyl]-4-[[4-(4-morpholinylmethyl)phenyl]ethynyl]benzamide;N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[2-[4-(morpholin-4-ylmethyl)phenyl]ethynyl]benzamide;Benzamide, N-[(1S,2R)-2-hydroxy-1-[(hydroxyamino)carbonyl]propyl]-4-[2-[4-(4-morpholinylmethyl)phenyl]ethynyl]-;N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[2-[4-(morphChemicalbookolin-4-ylmethyl)phenyl]ethynyl]benzamide
CBNumber:
CB62645119
Molecular Formula:
C24H27N3O5
Molecular Weight:
437.49
MOL File:
728865-23-4.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:13
Request For Quotation

CHIR-090 Properties

Density 1.33±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility ≥21.85 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form solid
pka 9.11±0.40(Predicted)
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS05,GHS08
Signal word  Danger
Hazard statements  H315-H318-H334-H317-H341-H361-H370-H413
Precautionary statements  P201-P202-P260-P264-P270-P272-P273-P280-P284-P302+P352-P304+P341-P305+P351+P338-P310-P308+P313-P321-P362+P364-P333+P313-P342+P311-P363-P405-P501
NFPA 704
0
3 0

CHIR-090 price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML3092 CHIR-090 ≥98% (HPLC) 728865-23-4 5MG ₹13628.68 2022-06-14 Buy
Sigma-Aldrich(India) SML3092 CHIR-090 ≥98% (HPLC) 728865-23-4 25MG ₹54871.93 2022-06-14 Buy
Product number Packaging Price Buy
SML3092 5MG ₹13628.68 Buy
SML3092 25MG ₹54871.93 Buy

CHIR-090 Chemical Properties,Uses,Production

Description

CHIR-090 is the first reported compound that in fact kills both E. coli and Pseudomonas aeruginosa in bacterial disk diffusion assays (Liang et al. 2011). Nonetheless, CHIR-090 was about 600-fold less effective against LpxC orthologs from the Rhizobiaceae family than against E. coli LpxC. In this way, studies have shown that the removal of morpholine ring, based on a chemical scaffold of reduced radius, was able to increase affinity by 20-fold for LpxC enzymes from the Rhizobiaceae family of bacteria and enhance the antibiotic activity against E. coli and P. aeruginosa by 2–4 fold over CHIR-090.

CHIR-090 Preparation Products And Raw materials

Raw materials

methyl 4-(2-(trimethylsilyl)ethynyl)benzoate 4-ETHYNYLBENZOIC ACID SODIUM SALT 4-Iodobenzaldehyde Methyl 4-iodobenzoate Morpholine

Preparation Products

CHIR-090 Suppliers

Global( 87)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32836 60 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29825 58 Inquiry
Dayang Chem (Hangzhou) Co.,Ltd. 571-88938639 +8617705817739 China 52861 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
PT CHEM GROUP LIMITED China 35426 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
Supplier Advantage
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
BOC Sciences 58
career henan chemical co 58
Dayang Chem (Hangzhou) Co.,Ltd. 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
TargetMol Chemicals Inc. 58
PT CHEM GROUP LIMITED 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58

CHIR-090 Spectrum

CHIR-090(728865-23-4)1HNMR

728865-23-4(CHIR-090)Related Search:

6,8-DIFLUORO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-ONE N-Hydroxy-5-Methyl-1H-Indole-3-carboxiMidaMide 5-(Bromomethyl)-2-methylthiazole 3-Azetidinone, 1-[(4-methylphenyl)sulfonyl]- L-tert-leucinaMide hydrochloride
Thiazole-2,4-diaMine hydrochloride Bicyclo[3.1.0]hexan-3-amine hydrochloride 4-[[4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone
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CHIR-090 N-[(1S,2R)-2-Hydroxy-1-[(hydroxyamino)carbonyl]propyl]-4-[[4-(4-morpholinylmethyl)phenyl]ethynyl]benzamide N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[2-[4-(morpholin-4-ylmethyl)phenyl]ethynyl]benzamide CHIR-090 (CHIR 090 CS-2285 Benzamide, N-[(1S,2R)-2-hydroxy-1-[(hydroxyamino)carbonyl]propyl]-4-[2-[4-(4-morpholinylmethyl)phenyl]ethynyl]- N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[2-[4-(morphChemicalbookolin-4-ylmethyl)phenyl]ethynyl]benzamide N-((2S,3R)-3-Hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl)-4-((4-(morpholinomethyl)phenyl)ethynyl)benzamide 728865-23-4