ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Epigenetics >Epigenetic Reader Domain inhibitors >GSK1324726A (I-BET726)

GSK1324726A (I-BET726)

CAS No.: 1300031-52-0

Chemical Name:: GSK1324726A (I-BET726)

Synonyms: GSK1324726A;CS-1736;I-BET726;I-BET726; I-BET 726;GSK1324726A (I-BET726);I-BET726 (GSK1324726A);GSK1324726A (I-BET726) USP/EP/BP;GSK-1324726A,Apoptosis,GSK1324726A,Inhibitor,Epigenetic Reader Domain,inhibit;4-(cis-1-Acetyl-4-((4-chlorophenyl)amino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoic acid;4-((2S,4R)-1-acetyl-4-(4-chlorophenylamino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoic acid

CBNumber:: CB62677051

Molecular Formula:: C25H23ClN2O3

Molecular Weight:: 434.91

MOL File:: 1300031-52-0.mol

MSDS File:: SDS

Modify Date:: 2024/7/2 8:55:13

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GSK1324726A (I-BET726) Properties

Boiling point	707.3±60.0 °C(Predicted)
Density	1.304±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	insoluble in H2O; ≥1.87 mg/mL in EtOH with gentle warming and ultrasonic; ≥17.7 mg/mL in DMSO
form	Powder
pka	4.20±0.10(Predicted)
color	White to light yellow
InChIKey	FAWSUKOIROHXAP-NPMXOYFQSA-N
SMILES	C(O)(=O)C1=CC=C(C2C=CC3=C(C=2)[C@H](NC2=CC=C(Cl)C=C2)C[C@H](C)N3C(C)=O)C=C1

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P280-P305+P351+P338

NFPA 704

	0
2		0

GSK1324726A (I-BET726) Chemical Properties,Uses,Production

Description

I-BET726 is an inhibitor of BET family proteins that binds BRD2, BRD3, and BRD4 with high affinity (IC₅₀s = 41, 31, and 22 nM, respectively) and competes with tetra-acetylated histone 4 peptides for binding to the bromodomains of these proteins. It exhibits >1,000-fold selectivity for these proteins over other bromodomain-containing homologs. I-BET726 inhibits cell growth and induces cytotoxicity in neuroblastoma cell lines by modulating the expression of genes involved in apoptosis and Myc signaling. I-BET726 can be administered orally to animals, and it reduces tumor growth in mouse xenograft models of human neuroblastoma.

GSK1324726A (I-BET726) Preparation Products And Raw materials

Raw materials

Preparation Products

GSK1324726A (I-BET726) Suppliers

Global( 72)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	China	13256	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	24200	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry
LEAP CHEM CO., LTD.	+86-852-30606658	China	24738	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354	United States	19973	58	Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	China	8474	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	57511	58	Inquiry
Amadis Chemical Company Limited	571-89925085	China	131980	58	Inquiry
AdooQ Bioscience CHINA	025-58849295 18951903616;	China	2990	60	Inquiry

Supplier	Advantage
A.J Chemicals	58
Zhengzhou Alfa Chemical Co.,Ltd	58
Dideu Industries Group Limited	58
InvivoChem	58
LEAP CHEM CO., LTD.	58
TargetMol Chemicals Inc.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
AdooQ Bioscience CHINA	60

GSK1324726A (I-BET726) Spectrum

GSK1324726A (I-BET726)(1300031-52-0)¹HNMR

1300031-52-0(GSK1324726A (I-BET726))Related Search:

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4-((2S,4R)-1-acetyl-4-(4-chlorophenylamino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoic acid 4-[(2S,4R)-1-Acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydro-6-quinolinyl]benzoic acid GSK1324726A (I-BET726) 4-(cis-1-Acetyl-4-((4-chlorophenyl)amino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoic acid I-BET726; I-BET 726 CS-1736 4-[(2S,4R)-1-Acetyl-4-[(4-chlorophenyl)amino]-1,2,3,4-tetrahydro-2-methyl-6-quinolinyl]benzoic acid I-BET726 Benzoic acid, 4-[(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-1,2,3,4-tetrahydro-2-methyl-6-quinolinyl]- GSK1324726A (I-BET726) USP/EP/BP GSK1324726A GSK-1324726A,Apoptosis,GSK1324726A,Inhibitor,Epigenetic Reader Domain,inhibit I-BET726 (GSK1324726A) 1300031-52-0 Inhibitors