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ChemicalBook > Product Catalog >API >Antibiotics >Cephalosporins Drugs >Cefodizime

Cefodizime

Cefodizime Structure
CAS No.
69739-16-8
Chemical Name:
Cefodizime
Synonyms
FIR-221;Estrofan;Cefodizim;Cefodizme;CEFODIZIME;Cefodizime,CDZM;CefodizMe SodiuM;Sodium cefodizime;CEFODIZIME FREE ACID;Cefodizime USP/EP/BP
CBNumber:
CB6299020
Molecular Formula:
C20H20N6O7S4
Molecular Weight:
584.67
MOL File:
69739-16-8.mol
Modify Date:
2024/4/28 15:15:04
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Cefodizime Properties

Melting point >170°C (dec.)
alpha D25 -55.9°
Density 1.86±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility DMSO (Slightly), Methanol (Slightly, Heated)
form Solid
pka pK1 2.85; pK2 3.37; pK3 4.18(at 25℃)
color White to Off-White
CAS DataBase Reference 69739-16-8(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Hazard Codes  Xi
Risk Statements  36/37/38-42/43
Safety Statements  22-26-36/37/39

Cefodizime Chemical Properties,Uses,Production

Chemical Properties

Cefodizime Sodium is a white to light yellowish white crystalline powder. It has no odor or a slightly peculiar odor and has a bitter taste. It is highly soluble in water (around 270g/L) but only sparingly soluble in ethanol or ether.

Definition

ChEBI: Cefodizime is a cephalosporin compound having 5-(carboxymethyl)-4-methyl-1,3-thiazol-2-yl]sulfanyl}methyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups located at positions 3 and 7 respectively. It has a role as an antibacterial drug and an EC 1.14.18.1 (tyrosinase) inhibitor. It is a cephalosporin, a member of 1,3-thiazoles and an oxime O-ether.

Preparation

The synthesis of cefodizime involved the following steps:
Dissolve 6.1g of (2-mercapto-4-methylthiazol-5-yl) acetic acid in water and adjust the pH to 6.5 by adding 2 mol/L sodium hydroxide.
Heat the solution to 70°C and then add a solution of 12g of cefotaxime in 75ml of water with stirring.
Keep stirring the mixture at 70°C for 3 hours while maintaining the pH at 6.5 by adding 2 mol/L sodium hydroxide.
Cool the mixture to room temperature and acidify it to pH 2.8.
Filter the resulting precipitate and wash it with water.
Dry the precipitate under vacuum and in the presence of phosphorus pentoxide.
As a result, 10g of cefodizime is obtained.
Cefodizime, an aminothiazolylcephalosporin. V. Synthesis and structure-activity relationships in the cefodizime series. DOI: 10.7164/antibiotics.40.29

Cefodizime Preparation Products And Raw materials

Raw materials

2-Mercapto-4-methyl-5-thiazoleacetic acid Cefotaxime Ethyl acetate 2-Aminothiazole-4-acetic acid Cyclohexylurea
1-Hydroxybenzotriazole hydrate Dicyclohexylcarbodiimide Formamide
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Preparation Products

T 2588G

Cefodizime Suppliers

Global( 154)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Hebei Mojin Biotechnology Co., Ltd +8613288715578 China 12456 58 Inquiry
Hebei Guanlang Biotechnology Co., Ltd. +86-19930503282 China 8826 58 Inquiry
Xiamen AmoyChem Co., Ltd +86-592-6051114 +8618959220845 China 6387 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
SIMAGCHEM CORP +86-13806087780 China 17367 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Pharma Affiliates 58
Hebei Mojin Biotechnology Co., Ltd 58
Hebei Guanlang Biotechnology Co., Ltd. 58
Xiamen AmoyChem Co., Ltd 58
CONIER CHEM AND PHARMA LIMITED 58
career henan chemical co 58
SIMAGCHEM CORP 58
TargetMol Chemicals Inc. 58

69739-16-8(Cefodizime)Related Search:

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2-Mercapto-4-methyl-1,3-thiazol-5-yl-acetic acid Ceftizoxime sodium Cefetamet hydrochloride Cefodizime 2-MERCAPTO-4-METHYL-5-HYDROXYETHYLTHIAZOLE
2-(2-AMINOTHIAZOL-4-YL)ETHYLAMINE 4-METHYL-5-THIAZOLEACETIC ACID 4,5-DIMETHYL-THIAZOLE-2-THIOL 4-Thiazoleacetamide 2-(2-AMINO-THIAZOL-4-YL)-ACETAMIDE
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CEFODIZIME Cefodizime,CDZM 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[[5-(carboxymethyl)-4-methyl-2-thiazolyl]thio]methyl]-8-oxo-, (6R,7R)- 7-(α-(Z)-Methoxyimino-α-(2-aminothiazol-4-yl)acetamido)-3-((5-carboxymethyl-4-methylthiazol-2-yl)thiomethyl)-3-cephem-4-carboxylic acid 7-(((2-Amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(((5-(carboxymethyl)-4-methyl-2-thiazolyl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid FIR-221 Cefodizme CefodizMe SodiuM Sodium cefodizime Cefodizim 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-[[[5-(carboxymethyl)-4-methyl-2-thiazolyl]thio]methyl]-8-oxo-, (6R,7R)- CEFODIZIME FREE ACID CefodiziMe acid USP/EP/BP Cefodizime USP/EP/BP (6R,7R)-7-((Z)-2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-(((5-(carboxymethyl)-4-methylthiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Estrofan 69739-16-8 C20H20N6O7S4 C20H19N6NaO7S4 Pharmaceutical intermediate