Ceftizoxime
- CAS No.
- 68401-81-0
- Chemical Name:
- Ceftizoxime
- Synonyms
- Cefimx;Ceftizox;EPOCELIN;FR-13749;Ceftisomin;CEFTIZOXIME;Ceftizoxime >CEFTIZOXIME ACID;Ceftizoxime (350 mg);Ceftizoxime, ≥ 98.0%
- CBNumber:
- CB1717299
- Molecular Formula:
- C13H13N5O5S2
- Molecular Weight:
- 383.4
- MOL File:
- 68401-81-0.mol
- Modify Date:
- 2024/5/28 19:59:05
| Melting point | 227° (dec) |
|---|---|
| Density | 1.89±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | Aqueous Base (Slightly), DMSO (Slightly, Heated), Methanol (Slightly, Heated, Sonicated) |
| form | Solid |
| pka | pKa 2.1 (Uncertain) |
| color | White to Pale Yellow |
| Merck | 14,1951 |
| Stability | Hygroscopic |
| InChIKey | NNULBSISHYWZJU-LLKWHZGFSA-N |
| SMILES | N12[C@@]([H])([C@H](NC(/C(/C3=CSC(N)=N3)=N\OC)=O)C1=O)SCC=C2C(O)=O |
| CAS DataBase Reference | 68401-81-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| RTECS | XI0367375 | |||||||||
| HS Code | 2941906000 | |||||||||
| Toxicity | LD50 intravenous in rat: 8gm/kg | |||||||||
| NFPA 704 |
|
Ceftizoxime price More Price(2)
Ceftizoxime Chemical Properties,Uses,Production
Description
In ceftizoxime, the whole C-3 side chain has been omitted to prevent deactivation by hydrolysis. It rather resembles cefotaxime in its properties; however, not being subject to metabolism, its pharmacokinetic properties are much less complex.
Uses
Ceftizoxime is used for bacterial infections of the lower respiratory tract, infections of the urinary tract, infections of the bones, joints, skin, soft tissues, and abdominal infections. Synonyms of this drug are ceftix and eposerin.
Definition
ChEBI: A parenteral third-generation cephalosporin, bearing a 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino group at the 7beta-position.
Antimicrobial activity
A semisynthetic cephalosporin supplied as the sodium salt. The
properties are very similar to those of cefotaxime, but it lacks
the acetoxymethyl group at position C-4 and is therefore not
subject to deacetylation. Activity against common pathogenic
bacteria (Table 13.4) is very similar to that of cefotaxime.
A 500 mg intramuscular injection achieves a plasma concentration
of around 14 mg/L. A concentration of 85–90 mg/L
is produced 30 min at the end of a 30-min intravenous infusion.
The plasma half-life is 1.3–1.9 h. Protein binding is
30%. It is well distributed. In children with meningitis receiving
200–250 mg/kg per day in four equally divided doses for
14–21 days, mean CSF concentrations 2 h after a dose were
6.4 mg/L on day 2 and 3.6 mg/L on day 14.
About 70–90% of the dose is recovered in the urine in the first
24 h, principally by glomerular filtration. Probenecid increases
the plasma half-life by about 50%. In patients receiving 1 g
intravenously over 30 min, the plasma elimination half-life rose
to 35 h when the corrected creatinine clearance was <10 mL/
min. It is partly removed by peritoneal and hemodialysis.
Adverse reactions and clinical use are similar to those of
cefotaxime.
Ceftizoxime Preparation Products And Raw materials
Raw materials
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