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Afzelin

CAS No.: 482-39-3

Chemical Name:: Afzelin

Synonyms: AFZELIN;KaeMpferin;KAEMPFEROL 3-O-RHAMNOSIDE;Afzeloside;Kaempferol 3-rhamnoside;Kaempferol 3-O-α-L-Rhamnoside;KAEMPFEROL 3-O-GLUCORHAMNOSIDE;KAEMPFERIN; KAEMPFEROL-3-RHAMNOSIDE;Afzelin/Kaempferol 3-o-glucorhamnoside;3-(α-L-Rhamnopyranosyloxy)-5,7,4'-trihydroxyflavone

CBNumber:: CB6321426

Molecular Formula:: C21H20O10

Molecular Weight:: 432.38

MOL File:: 482-39-3.mol

MSDS File:: SDS

Modify Date:: 2024/5/29 15:34:05

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Afzelin Properties

Melting point	172-174 °C (decomp)(Solv: water (7732-18-5))
Boiling point	765.6±60.0 °C(Predicted)
Density	1.70±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	Soluble in methan
form	powder
pka	6.20±0.40(Predicted)
color	Yellow

Afzelin Chemical Properties,Uses,Production

Description

Afzelin (Synonyms: Kaempferol-3-O-rhamnoside) is a flavonoid isolated from Thesium chinense Turcz. and widely distributed in Korea and China. It has anti-inflammatory, anti-oxidative stress response, anti-apoptotic, and anti-cardiac cytotoxic effects. AfzelinIt can reduce mitochondrial damage, enhance mitochondrial biosynthesis, and reduce mitochondria-related proteins. Parkinand PTENinduced putative kinase 1 (putative kinase 1)s level. AfzelinCan be improved D-galactosamine(GalN)/LPSSurvival rate of mice treated with doxorubicin prophylaxis Induced cardiotoxicity and scopolamine -induced neurological injury. AfzelinAlso inhibits asthma and allergies caused by ovalbumin.

Uses

Kaempferol 3-O-α-L-Rhamnoside is found in Cornus macrophylla and has shown to have antibacterial activity against Pseudomonas aeruginosa, a leading cause of illness in immunocompromised individuals.

Definition

ChEBI: Afzelin is a glycosyloxyflavone that is kaempferol attached to an alpha-L-rhamnosyl residue at position 3 via a glycosidic linkage. It has a role as a plant metabolite, an antibacterial agent and an anti-inflammatory agent. It is a glycosyloxyflavone, a trihydroxyflavone and a monosaccharide derivative. It is functionally related to a kaempferol. It is a conjugate acid of an afzelin(1-).

References

[1] SO-YOUNG OH. Central administration of afzelin extracted from Ribes fasciculatum improves cognitive and memory function in a mouse model of dementia.[J]. Scientific Reports, 2021: 9182. DOI:10.1038/s41598-021-88463-6.
[2] LEI XIA. Afzelin induces immunogenic cell death against lung cancer by targeting NQO2.[J]. BMC Complementary Medicine and Therapies, 2023, 23 1: 381. DOI:10.1186/s12906-023-04221-3.
[3] EVA RACHMI. Identification of afzelin potential targets in inhibiting triple-negative breast cancer cell migration using reverse docking.[J]. Porto biomedical journal, 2020, 5 6: e095. DOI:10.1097/j.pbj.0000000000000095.
[4] SIMPLICE JOEL NDENDOUNG TATSIMO. Antimicrobial and antioxidant activity of kaempferol rhamnoside derivatives from Bryophyllum pinnatum.[J]. BMC Research Notes, 2012, 5: 158. DOI:10.1186/1756-0500-5-158.
[5] YOUNG-KYOON KIM. Isolation of flavonol rhamnosides fromloranthus tanakae and cytotoxic effect of them on human tumor cell lines[J]. Archives of Pharmacal Research, 2004, 27 1: 44-47. DOI:10.1007/BF02980044.
[6] VINIT RAJ. Antiviral activities of 4H-chromen-4-one scaffold-containing flavonoids against SARS–CoV–2 using computational and in vitro approaches[J]. Journal of Molecular Liquids, 2022, 353: Article 118775. DOI:10.1016/j.molliq.2022.118775.
[7] BORBáLA VERMES . The synthesis of afzelin, paeonoside and kaempferol 3-O-β-rutinoside[J]. Phytochemistry, 1976, 15 8: Pages 1320-1321. DOI:10.1016/0031-9422(76)85106-0.

Afzelin Preparation Products And Raw materials

Raw materials

Preparation Products

Afzelin Suppliers

Global( 128)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	CHINA	1824	58	Inquiry
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	China	3424	58	Inquiry
Shaanxi Pioneer Biotech Co., Ltd .	+8613259417953	China	3000	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29826	58	Inquiry
Hubei Ipure Biology Co., Ltd	+8613367258412	China	10326	58	Inquiry
Apeloa Pharmaceutical Co., Ltd.	+86-0571-87635730 +8615858229168	China	1478	58	Inquiry
Finetech Industry Limited	+86-27-87465837 +8618971612321	China	9626	58	Inquiry
Labnetwork lnc.	+86-27-50766799 +8618062016861	China	19994	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354	United States	19973	58	Inquiry
ZHEJIANG JIUZHOU CHEM CO., LTD	+86-0576225566889 +86-13454675544	China	19947	58	Inquiry

Supplier	Advantage
Chengdu GLP biotechnology Co Ltd	58
Chengdu Biopurify Phytochemicals Ltd.	58
Shaanxi Pioneer Biotech Co., Ltd .	58
career henan chemical co	58
Hubei Ipure Biology Co., Ltd	58
Apeloa Pharmaceutical Co., Ltd.	58
Finetech Industry Limited	58
Labnetwork lnc.	58
TargetMol Chemicals Inc.	58
ZHEJIANG JIUZHOU CHEM CO., LTD	58

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