SL0101

CAS No.: 77307-50-7

Chemical Name:: SL0101

Synonyms: SL0101;SL 0101-1;RSK Inhibitor, SL0101;3'',4''-Di-O-acetylafzelin;SL-0101-1;SL0101-1;SL-0101;SL 0101;SL0101;SL0101 1;Kaempferol 3-O-(3'',4''-di-O-acetyl-alpha-L-rhamnopyranoside);3-(3-O,4-O-Diacetyl-α-L-rhamnopyranosyloxy)-4',5,7-trihydroxyflavone;3-[(3-O,4-O-Diacetyl-6-deoxy-α-L-mannopyranosyl)oxy]4',5,7-trihydroxyflavone;2-(4-Hydroxyphenyl)-4-oxo-5,7-dihydroxy-4H-1-benzopyran-3-yl 3-O,4-O-diacetyl-α-L-rhamnopyranoside;2-(4-Hydroxyphenyl)-3-(3-O,4-O-diacetyl-α-L-rhamnopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one

CBNumber:: CB8507631

Molecular Formula:: C25H24O12

Molecular Weight:: 516.45

MOL File:: 77307-50-7.mol

Modify Date:: 2023/6/30 15:45:59

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SL0101 Properties

Melting point	128-132°C
Boiling point	753.0±60.0 °C(Predicted)
Density	1.57±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Acetone (Slightly), Methanol (Slightly)
form	Yellow solid
pka	6.20±0.40(Predicted)
color	Pale Yellow to Brown

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338
HS Code	2940000080

SL0101 price More Price(1)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	559285	RSK Inhibitor, SL0101 The RSK Inhibitor, SL0101 controls the biological activity of RSK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphoryla	77307-50-7	1MG	₹21460	2022-06-14	Buy

Product number	Packaging	Price	Buy
559285	1MG	₹21460	Buy

SL0101 Chemical Properties,Uses,Production

Description

The p90 ribosomal S6 kinases (RSK) 1-4 are downstream members of the extracellular signal-regulated kinase (ERK)/MAPK cascade. SL 0101-1 is a kaempferol glycoside, isolated from the tropical plant F. refracta, that selectively inhibits RSK2 with an IC₅₀ value of 89 nM (K_i = 1 μM) without interfering with upstream activators of RSK, including ERK, MEK, EGFR, and PKC. At 100 μM, SL 0101-1 inhibits the proliferation of MCF-7 breast cancer cells, arresting cells in the G₁ phase of the cell cycle. SL 0101-1 has been used to characterize the intracellular signaling events associated with angiotensin II-induced tyrosine kinase activation with a concentration of 30 μM attenuating angiotensin II-induced cell proliferation.

Chemical Properties

Tan Solid

Biological Activity

Selective inhibitor of p90 ribosomal S6 kinase (RSK) (IC 50 = 89 nM for RSK2). Does not inhibit upstream kinases such as MEK, Raf and PKC.? Inhibits the growth of MCF-7 human breast cancer cells with no effect on the normal breast cell line.

SL0101 Preparation Products And Raw materials

Raw materials

Preparation Products

SL0101 Suppliers

Global( 78)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	China	11681	58	Inquiry
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	China	33350	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	52927	58	Inquiry
RD International Technology Co., Limited	18024082417	China	9268	58	Inquiry
TargetMol Chemicals Inc.	15002134094	China	28091	58	Inquiry
InvivoChem	13549236410	China	6755	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
BOC Sciences	58
TargetMol Chemicals Inc.	58
InvivoChem	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58
RD International Technology Co., Limited	58
TargetMol Chemicals Inc.	58
InvivoChem	58

77307-50-7(SL0101)Related Search:

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SL0101

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3-[(3,4-Di-O-acetyl-6-deoxy-α-L-Mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one Kaempferol 3-O-(3'',4''-di-O-acetyl-alpha-L-rhamnopyranoside) SL0101 2-(4-Hydroxyphenyl)-3-(3-O,4-O-diacetyl-α-L-rhamnopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one 2-(4-Hydroxyphenyl)-4-oxo-5,7-dihydroxy-4H-1-benzopyran-3-yl 3-O,4-O-diacetyl-α-L-rhamnopyranoside 3-(3-O,4-O-Diacetyl-α-L-rhamnopyranosyloxy)-4',5,7-trihydroxyflavone 3-[(3-O,4-O-Diacetyl-6-deoxy-α-L-mannopyranosyl)oxy]4',5,7-trihydroxyflavone SL 0101-1 3-[(3,4-Di-O-acetyl-6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydro-2-(4-hydroxyphenyl)-4H-1benzopyran-4-one 3'',4''-Di-O-acetylafzelin SL-0101-1;SL0101-1;SL-0101;SL 0101;SL0101;SL0101 1 RSK Inhibitor, SL0101 4H-1-Benzopyran-4-one, 3-[(3,4-di-O-acetyl-6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)- (2S,3S,4S,5R,6S)-6-((5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl)oxy)-5-hydroxy-2-methyltetrahydro-2H-pyran-3,4-diyl diacetate 77307-50-7 13C & 2H Sugars Carbohydrates & Derivatives Inhibitors