Kaempferol
- CAS No.
- 520-18-3
- Chemical Name:
- Kaempferol
- Synonyms
- kaempherol;kempferol;KAEMPFEROL 98%;3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chroMen-4-one;campherol;pelargidenolon;Kaempferol Hydrate;3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one;3,4';asurone
- CBNumber:
- CB5223176
- Molecular Formula:
- C15H10O6
- Molecular Weight:
- 286.24
- MOL File:
- 520-18-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/11 13:57:21
| Melting point | 276°C |
|---|---|
| Boiling point | 348.61°C (rough estimate) |
| Density | 1.2981 (rough estimate) |
| refractive index | 1.4413 (estimate) |
| storage temp. | 2-8°C |
| solubility | ethanol: 20 mg/mL |
| pka | 6.34±0.40(Predicted) |
| form | powder |
| Colour Index | 75640 |
| color | yellow |
| Merck | 14,5274 |
| BRN | 304401 |
| Stability | Unstable in Solution |
| InChIKey | IYRMWMYZSQPJKC-UHFFFAOYSA-N |
| LogP | 2.685 (est) |
| CAS DataBase Reference | 520-18-3(CAS DataBase Reference) |
| IARC | 3 (Vol. 31, Sup 7) 1987 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| Hazard Codes | Xi,T | |||||||||
| Risk Statements | 36/37/38-68-25 | |||||||||
| Safety Statements | 26-36-45-36/37-36/37/38-22 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | - | |||||||||
| RTECS | LK9275200 | |||||||||
| F | 8-10-23 | |||||||||
| HS Code | 29329990 | |||||||||
| NFPA 704 |
|
Kaempferol price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | K0133 | Kaempferol ≥90% (HPLC), powder | 520-18-3 | 10MG | ₹6743.98 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | K0133 | Kaempferol ≥90% (HPLC), powder | 520-18-3 | 50MG | ₹22364.45 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | K0133 | Kaempferol ≥90% (HPLC), powder | 520-18-3 | 100MG | ₹28329.03 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR2705 | Kaempferol Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 30?mg | 520-18-3 | 30MG | ₹34066.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | K0133 | Kaempferol ≥90% (HPLC), powder | 520-18-3 | 500MG | ₹83255.08 | 2022-06-14 | Buy |
Kaempferol Chemical Properties,Uses,Production
Chemical Properties
Yellow Solid
Uses
Kaempferol, is used as an inhibitor of Fatty Acid Synthase, Cox-1 activity, and Topo I. It also Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro. Also blocks EGF-induced histone H3Ser10 phosphorylation in mouse epidermal JB6 C141 cells.
General Description
Kaempferol is a polyphenolic antioxidant abundantly present in vegetables and fruits. It has a diphenylpropane structure. In many plants, it is present as a glycosidic form namely, kaempferol-3-O-glucoside.
Biological Activity
Naturally occurring flavonoid found in Gingko biloba and red wines that activates the mitochondrial Ca 2+ uniporter (EC 50 = 7 μ M). Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro .
Anticancer Research
Kaempferol is one of the secondary metabolites found in some plants, plant-derivedfoods, and traditional medicines. It is a flavonoid compound obtained from someedible plants including grapes, tea, strawberries, broccoli, tomato, cabbage, leek,kale, endive, and beans. It inhibits growth and migration of pancreatic cancer cellsby acting on proto-oncogene tyrosine kinase (Src), ERK1/2, and AKT pathways(Singh et al. 2016a). It is being investigated in pancreatic and lung cancers toevaluate its antiangiogenic, anticancer, and radical scavenging activities. It showsmoderate cytostatic activity in PC3, HeLa, and K562 human cancer cells. It isidentified as aryl hydrocarbon receptor antagonist and acts against ABCG2 (ATP-bindingcassette subfamily G member 2)-mediated multidrug resistance bypreventing the ABCG2 upregulation in esophageal carcinoma. It induces theapoptosis of ovarian cancer cell by activating p53 in intrinsic pathway mechanism.It is an inhibitor of breast cancer resistance protein (BCRP), quinine reductase-2,and a substrate of BCRP (Calderon-Montano et al. 2011; Wang et al. 2012).
Kaempferol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| chakrachem Lifesciences | +91 9902744663 | Hyderabad, India | 451 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Saraf Resin & Chemicals Private Limited | 09700925769 | Hyderabad, India | 28 | 58 | Inquiry |
| Natucare India | 08048372644Ext 102 | Mumbai, India | 8 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Maas Pharma Chemicals | +91-9958666224 | Delhi, India | 1607 | 58 | Inquiry |
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