Carteolol hydrochloride
- CAS No.
- 51781-21-6
- Chemical Name:
- Carteolol hydrochloride
- Synonyms
- endak;oc1085;Teoptic;Tenalet;Cartrol;Carteol;Cartelo;mikelan;opc1085;Cartelol
- CBNumber:
- CB6335371
- Molecular Formula:
- C16H25ClN2O3
- Molecular Weight:
- 328.83
- MOL File:
- 51781-21-6.mol
- Modify Date:
- 2024/7/2 8:55:14
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| RTECS | VC8282000 | |||||||||
| HS Code | 2933790002 | |||||||||
| Toxicity | LD50 in male mice, rats (mg/kg): 810, 1380 orally; 54.5, 158 i.v.; 380, 400 i.p. (Lang) | |||||||||
| NFPA 704 |
|
Carteolol hydrochloride Chemical Properties,Uses,Production
Chemical Properties
Crystalline Solid
brand name
Cartrol (Abbott); Ocupress (Novartis).
Pharmacology
Carteolol hydrochloride is a powerful beta-adrenergic receptor antagonist characterized by a long-term pharmacological action, the lack of beta receptor selectivity, an intrinsic sympathomimetic activity (ISA), and a slight local anaesthetic activity (approximately 1/10 of that of propranolol). This drug has a dose-dependent hypotensive effect and does not engender the onset of tachyphylaxis. The pharmacological action consists in the decreased formation of aqueous humor, probably by acting at the level of the ciliary body presenting a wealth of ?2 receptors. The intrinsic sympathomimetic activity of carteolol is responsible for the low incidence of side effects and, thus, for maintaining the heart rate, pulse rate, and arterial blood pressure within the normal physiological range.
Pharmacokinetics
The instillation of carteolol hydrochloride is followed by the rapid absorption by the ocular tissues. Following the instillation of 10μl of 14C-carteolol ophthalmic solution 20 mg/ml into rabbit eyes, the highest platelet and tissue concentrations were obtained between 30 minutes to 2 hours. The study shows that, following topical application, carteolol spreads rapidly into the ocular tissues, passing the corneal barrier. The highest concentrations of 14C-carteolol were found in the following ocular tissues: cornea, iris, anterior sclera, ciliary body conjunctiva, and extraocular muscle. Slightly lower concentrations were found in the retina, choroid, posterior sclera, optic nerve, and aqueous humor. The concentration was especially low in the lens, vitreous body, and plasma. In the various tissues of the contralateral eye, very low radioactivity levels were measured. After the instillation of one drop of carteolol ophthalmic solution 20 mg/ml in healthy volunteers, the plasma concentrations were negligible (1-2 ng/ml). Approximately 16% of the dose is excreted in the urine as an unchanged compound during the first 24 hours after the instillation of a single drop of carteolol hydrochloride 20 mg/ml. The urinary elimination half-life following topical application is about 5 hours.
Clinical Use
The chemical name for carteolol hydrochloride (carteolol) is (±)-5-[3-[(1,1-dimethyl ethyl) amino]-2-hydroxypropoxy]-3,4-dihydro-2(1H)-quinolinone monohydrochloride. Carteolol Hydrochloride (carteolol) Ophthalmic Solution USP, 1% is a nonselective beta-adrenoceptor blocking agent for ophthalmic use. Each mL of sterile solution contains Active: carteolol hydrochloride (carteolol) 10 mg (1%). This drug is used to treat open-angle glaucoma and other causes of high pressure inside the eye. Carteolol hydrochloride ophthalmic may interact with oral carteolol, digoxin, reserpine, insulin or oral diabetes medications, other beta-blockers, calcium channel blockers, or medicines to treat psychiatric disorders.
Carteolol hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| STELLENCE PHARMSCIENCE PVT TLD | +91-9820778787 +91-9820778787 | Bangalore, India | 25 | 58 | Inquiry |
| CNS CHEMICALS | +91-9381957258 +91-9381957258 | Telangana, India | 354 | 58 | Inquiry |
| EDMOND PHARMA | New Delhi, India | 5 | 58 | Inquiry | |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Stellence Pharmscience Private Limited | 08068970604Ext 488 | Karnataka, India | 22 | 58 | Inquiry |
| Cns Chemicals | 08066085913Ext 735 | Hyderabad, India | 262 | 58 | Inquiry |
| Kebee Pharmachemie Pvt., Ltd. | 91-22-28328669 | Maharashtra, India | 65 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
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