Tobramycin
- CAS No.
- 32986-56-4
- Chemical Name:
- Tobramycin
- Synonyms
- Tobramycin Base;Tobramycine;tobra;nebcin;tobrex;Tobramax;nf6;obracin;Tobracin;nebicina
- CBNumber:
- CB7154445
- Molecular Formula:
- C18H37N5O9
- Molecular Weight:
- 467.52
- MOL File:
- 32986-56-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/7 16:07:22
| Melting point | 178 °C |
|---|---|
| alpha | D20 +129° (c = 1 in water) |
| Boiling point | 570.01°C (rough estimate) |
| Density | 1.3458 (rough estimate) |
| refractive index | 143 ° (C=4, H2O) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | H2O: 50 mg/mL, clear, faintly yellow |
| pka | pKa 6.7 (Uncertain);8.3 (Uncertain);9.9 (Uncertain) |
| form | White to off-white solid |
| color | white to off-white |
| Water Solubility | Soluble in water |
| Merck | 14,9490 |
| BRN | 1357507 |
| Stability | Hygroscopic |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H361f | |||||||||
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | WK2100000 | |||||||||
| F | 3-10 | |||||||||
| HS Code | 29419090 | |||||||||
| Toxicity | LD50 in mice, rats (mg/kg): 441, 969 s.c. (Welles) | |||||||||
| NFPA 704 |
|
Tobramycin price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T4014 | Tobramycin Aminoglycoside antibiotic | 32986-56-4 | 100MG | ₹13163.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T4014 | Tobramycin Aminoglycoside antibiotic | 32986-56-4 | 500MG | ₹36729.23 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1079 | Tobramycin Pharmaceutical Secondary Standard; Certified Reference Material | 32986-56-4 | 1G | ₹10002.3 | 2022-06-14 | Buy |
| TCI Chemicals (India) | T2503 | Tobramycin | 32986-56-4 | 5G | ₹9700 | 2022-05-26 | Buy |
| TCI Chemicals (India) | T2503 | Tobramycin | 32986-56-4 | 25G | ₹23800 | 2022-05-26 | Buy |
Tobramycin Chemical Properties,Uses,Production
Description
Tobramycin is one component (factor 6) of a mixture produced by fermentation of Streptomyces tenebrari us. Lacking the C-3′ hydroxyl group, it is not a substrate for APH(3′)-1 and APH(3′)-II and so has an intrinsically broader spectrum than kanamycin. It is a substrate, however, for adenylation at C-2′ by ANT (2′) and acetylation at C-3 by AAC(3)-I and AAC(3)-II and at C-2′ by AAC(2′).
Chemical Properties
White or almost white powder.
Uses
Tobramycin is an aminoglycoside antibiotic.
Indications
Tobramycin is highly active with respect to Gram-negative microorganisms (blue-pus
bacillus and gastric bacilli, rabbit fever, serratia, providencia, enterobacteria, proteus, salmonella, shigella), as well as Gram-positive microorganisms (staphylococci, including
those resistant to penicillin and some cephalosporins), and a few strains of streptococci.
It is used for severe bacterial infections: peritonitis, sepsis, meningitis, osteomyelitis,
endocarditis, pneumonia, pleural empyema, pulmonary abscess, purulent skin infections
and soft tissue infections, and infections of the urinary tract caused by microorganisms that
are sensitive to the drug. Synonyms of this drug are nebicine, obracine, and others.
Definition
ChEBI: A amino cyclitol glycoside that is kanamycin B lacking the 3-hydroxy substituent from the 2,6-diaminoglucose ring.
Antimicrobial activity
In-vitro activity against Ps. aeruginosa is usually somewhat greater than that of gentamicin; against other organisms activity is similar or a little lower. Other Pseudomonas species are generally resistant, as are streptococci and most anaerobic bacteria. Other organisms usually susceptible in vitro include Acinetobacter, Legionella and Yersinia spp. Alkaligenes, Flavobacterium spp. and Mycobacterium spp. are resistant. It exhibits bactericidal activity at concentrations close to the MIC and bactericidal synergy typical of aminoglycosides in combination with penicillins or cephalosporins.
Acquired resistance
It is inactivated by many aminoglycoside-modifying enzymes
that inactivate gentamicin. However,
AAC(3′)-I does not confer tobramycin resistance and
AAC(3′)-II confers a lower degree of tobramycin resistance
than of gentamicin resistance. Conversely, ANT(4′) confers
tobramycin but not gentamicin resistance, as do some types
of AAC(6′). Overproduction of APH(3′), conferring a low
degree of resistance to tobramycin (MIC 8 mg/L), but not
gentamicin (MIC 2 mg/L), was ascribed to ‘trapping’ rather
than phosphorylation.
Resistance rates are generally similar to those of gentamicin,
although they may vary locally because of the prevalence
of particular enzyme types.
Biological Activity
Pharmacologically, tobramycin is quite similar to gentamicin. The drug is somewhat more active against Ps. aeruginosa than gentamicin. Tobramycin also acts synergistically with penicillin, but to a lesser degree than gentamicin.
Clinical Use
Severe infections caused by susceptible micro-organisms
Ps. aeruginosa infections, including chronic pulmonary infections in cystic
fibrosis (administration by injection or nebulizer)
For practical purposes use is identical to that of gentamicin,
except possibly for Pseudomonas infection, where it has somewhat
greater activity against gentamicin-susceptible and some
gentamicin-resistant strains. Its value as a substitute for gentamicin
in the speculative treatment of severe undiagnosed
infection is offset by its lower activity against other organisms
that may be implicated.
It has been used extensively to treat Ps. aeruginosa infections
in patients with cystic fibrosis.
Tobramycin Preparation Products And Raw materials
Raw materials
1of4
chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12460 | 58 | Inquiry |
| Hangzhou Hyper Chemicals Limited | +86-0086-57187702781 +8613675893055 | China | 200 | 58 | Inquiry |
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