Bekanamycin
- CAS No.
- 4696-76-8
- Chemical Name:
- Bekanamycin
- Synonyms
- kdm;NK-1006;NK 1006;KANAMYCIN B;Bekanamycin;nebramycinv;kanendomycin;Kanamycine B;Kanamycin B base;nebramycinfactor5
- CBNumber:
- CB7432846
- Molecular Formula:
- C18H37N5O10
- Molecular Weight:
- 483.51
- MOL File:
- 4696-76-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/7 19:09:42
| Melting point | 178-182° (dec) |
|---|---|
| alpha | D18 +130° (c = 0.5 in water); D21 +114° (c = 0.98 in water) |
| Boiling point | 580.49°C (rough estimate) |
| Density | 1.3771 (rough estimate) |
| refractive index | 1.7600 (estimate) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | Aqueous Acid (Slightly), Methanol (Slightly, Heated, Sonicated) |
| form | Solid |
| pka | 13.07±0.70(Predicted) |
| color | Crystals |
| Stability | Hygroscopic |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315; H319; H335 | |||||||||
| Precautionary statements | P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501 | |||||||||
| Toxicity | LD50 i.v. in mice: 136 mg/kg (Wakazawa) | |||||||||
| NFPA 704 |
|
Bekanamycin Chemical Properties,Uses,Production
Description
Bekanamycin, kanamycin B, was found in the culture broth of Streptomyces kanamyceticus by Umezawa et al. in 1957. It shows the same antibacterial spectrum as kanamycin but with stronger activity. The total synthesis of bekanamycin was completed by Umezawa et al. in 1968 and the knowledge gained from its synthesis was successfully applied to the synthesis of dibekacin.
Uses
Kanamycin B (cas# 4696-76-8) is a compound useful in organic synthesis.
Antimicrobial activity
A component of the mixture of kanamycins produced by
Streptomyces kanamyceticus. It is approximately twice as active
as kanamycin A and is twice as toxic. It is not active against
amikacin-resistant strains of MRSA. It is poorly active against
Ps. aeruginosa.
The pharmacokinetics and uses are similar to those of
kanamycin. A 0.5% ophthalmic solution has been used to
treat gonococcal ophthalmia neonatorum. It is available in
Japan.
Safety Profile
Poison by intravenous route.Moderately toxic by intraperitoneal and subcutaneousroutes. When heated to decomposition it emits toxicfumes of NOx.
Purification Methods
A small quantity of kanamycin B (24mg) can be purified on a small Dowex-1 x 2 column (6 x 50mm); the required fraction is evaporated to dryness and the residue crystallised from EtOH containing a small amount of H2O. [Umezawa et al. Bull Chem Soc Jpn 42 537 1969.] It has been crystallised from H2O by dissolving ~1g in H2O (3mL), adding Me2NCHO (3mL) and setting aside at 4o overnight. The needles are collected and dried to constant weight at 130o. It has also been recrystallised from aqueous EtOH. It is slightly soluble in CHCl3 and isoPrOH. [IR: Wakazawa et al. J Antibiot 14A 180, 187 1961, Ito et al. J Antibiot 17 A 189 1964, Beilstein 18 III/IV 7631.]
Bekanamycin Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Orgamine Chemicals(I) Pvt Ltd | +91-9820080281 +91-9820080281 | Maharashtra, India | 451 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | 18192627656 | China | 3002 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29899 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49403 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | China | 34571 | 58 | Inquiry |
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