ChemicalBook > Product Catalog >API >Antibiotics >Other antibiotic Drugs >Arbekacin

Arbekacin

CAS No.: 51025-85-5

Chemical Name:: Arbekacin

Synonyms: 1665RB;AHB-DKB;AHB[1KB;HABA-DKB;haberacin;habekacin;ARBEKACIN;Decontasin;Blubatosine;Arbekacin USP/EP/BP

CBNumber:: CB7347991

Molecular Formula:: C22H44N6O10

Molecular Weight:: 552.62

MOL File:: 51025-85-5.mol

MSDS File:: SDS

Modify Date:: 2022/12/21 16:56:50

Request For Quotation

Arbekacin Properties

Boiling point	904.0±65.0 °C(Predicted)
Density	1.47±0.1 g/cm3(Predicted)
pka	13.07±0.70(Predicted)
CAS DataBase Reference	51025-85-5(CAS DataBase Reference)

Arbekacin Chemical Properties,Uses,Production

Description

Arbekacin is a semi-synthetic derivative of dibekacin useful in the treatment of bacterial infections. This aminoglycoside is active against a broad spectrum of bacteria, including some of the gentamycin-, kanamycin-, and tobramycin-resistant pathogens. Compared to amikacin and dibekacin, ototoxicity is reportedly milder.

Definition

ChEBI: A kanamycin that is kanamycin B bearing an N-(2S)-4-amino-2-hydroxybutyryl group on the aminocyclitol ring.

Antimicrobial activity

The 1-N-(4-amino-2-hydroxybutyryl) derivative of dibekacin, to which it bears the same relation as amikacin bears to kanamycin A. Supplied as the sulfate.
Activity and stability to aminoglycoside-modifying enzymes are comparable with those of amikacin. It is active against many strains of methicillin-resistant Staph. aureus, either alone or in combination with β-lactam or other agents. Synergy with ampicillin has been observed for high-level gentamicin- and vancomycin-resistant enterococci.
A 3 mg/kg intravenous dose achieved a peak concentration of c. 8 mg/L after 1 h. The plasma half-life is about 2 h and protein binding 3–12%.
About 85% of the dose can be recovered from urine over 48 h. It is retained in renal failure, but moderately well removed by hemodialysis with a plasma half-life of 2–4 h. Peak concentrations of 10.9 mg/L and trough concentrations of 1.7 mg/L have been reported in patients treated for MRSA infection where C_max:MIC ratios of >25 and AUC:MIC ratios of >186 were associated with improved cure rates, and both Cmin and AUC were associated with the incidence of nephrotoxicity.
Toxicity and side effects are typical of the aminoglycoside class. It is used in severe infection cause by susceptible microorganisms, but is not widely available.

Arbekacin Preparation Products And Raw materials

Raw materials

N-Hydroxysuccinimide Ammonium hydroxide Trifluoroacetic acid 1-Methylpyrazole-4-ethoxycarbonyl-5-ethoxycarbonylsulfonamide 1,1-Dimethoxyethane

Bekanamycin Ammonia Acetic acid Benzyl chloroformate Hydrogen

Palladium hydroxide 2-HYDROXY BUTYRIC ACID

chevron_left

1of3

chevron_right

Preparation Products

Arbekacin Suppliers

Global( 55)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6257	58	Inquiry
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	China	6383	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49732	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29808	58	Inquiry
SIMAGCHEM CORP	+86-13806087780	China	17365	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	32159	58	Inquiry
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	China	7859	58	Inquiry
AFINE CHEMICALS LIMITED	+86-0571-85134551	China	15377	58	Inquiry
GIHI CHEMICALS CO.,LIMITED	+8618058761490	China	49984	58	Inquiry
Hebei Miaoyin Technology Co.,Ltd	+86-17367732028 +86-17367732028	China	3512	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Xiamen AmoyChem Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
SIMAGCHEM CORP	58
TargetMol Chemicals Inc.	58
Shaanxi Dideu Medichem Co. Ltd	58
AFINE CHEMICALS LIMITED	58
GIHI CHEMICALS CO.,LIMITED	58
Hebei Miaoyin Technology Co.,Ltd	58

51025-85-5(Arbekacin)Related Search:

Tris(hydroxymethyl)aminomethane Sisomicin ALTRENOGEST Glycine 6-Aminocaproic acid

Dibekacin 4-ACETAMIDOCYCLOHEXANOL DIBEKACIN SULFATE/INTERMEDIATE OF ARBEKACIN,INTERMEDIATE OF ARBEKACIN ARBEKACIN SULPHATE (1R,2R)-2-(PROPYLAMINO)CYCLOHEXANOL

TOBRAMYCIN A (1R,2R)-2-(ETHYLAMINO)CYCLOHEXANOL AMINO ACIDS Arbekacin GENTAMINE C1A

chevron_left

1of3

chevron_right

ARBEKACIN (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-[(2R,3R,6S)-3-amino-6-(aminomethyl)oxan-2-yl]oxy-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-[(2R,3R,6S)-3-amino-6-(aminomethyl)tetrahydropyran-2-yl]oxy-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methylol-tetrahydropyran-2-yl]oxy-3-hydroxy-cyclohexyl]-2-hydroxy-butyramide (2S)-N-[(1R,2S,3S,4R,5S)-4-[(2R,3R,6S)-6-(aminomethyl)-3-azanyl-oxan-2-yl]oxy-5-azanyl-2-[(2S,3R,4S,5S,6R)-4-azanyl-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-hydroxy-cyclohexyl]-4-azanyl-2-hydroxy-butanamide (s)-oxy-1-oxobutyl)-2-deoxy 3,4,6-tetradeoxy-alpha-d-erythro-hexopyranosyl-(1-4))-n(sup1)-(4-amino-2-hydr habekacin haberacin (S)-O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2，6-diamino-。2，3，4，6-tetradeoxy-α-D-erythro-hexopyranosyl-(1→4)-]- N^<1>^-(4-amino-2-hydroxy-1-oxobutyl)-2-deoxy-D-streptarnine 1665RB 1-N-[(S)-4-Amino-2-hydroxybutyryl]-3',4'-dideoxykanamycin B AHB-DKB D-Streptamine, O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl-(1→4)]-N1-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy- HABA-DKB (2S)-4-Amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-[(2R,3R,6S)-3-amino-6-(aminomethyl)oxan-2-yl]oxy-2-[(2R,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-hydroxy-cyclohexyl]-2-hydroxy-butanamide AHB[1KB Blubatosine Decontasin 4-O-[3-Amino-3-deoxy-α-D-glucopyranosyl]-6-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl]-N'-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-L-streptamine 6-O-(3-Amino-3-deoxy-α-D-glucopyranosyl)-4-O-(2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl)-N1-[(S)-4-amino-2-hydroxybutyryl]-2-deoxy-D-streptamine 2-[3-(4-bromophenyl)-2-cyclohexylimino-4-oxo-5-thiazolidinyl]acetic acid Arbekacin USP/EP/BP 51025-85-5 C22H44N6O10