Arbekacin
|
|
Arbekacin 속성
- 끓는 점
- 904.0±65.0 °C(Predicted)
- 밀도
- 1.47±0.1 g/cm3(Predicted)
- 산도 계수 (pKa)
- 13.07±0.70(Predicted)
- CAS 데이터베이스
- 51025-85-5(CAS DataBase Reference)
안전
Arbekacin C화학적 특성, 용도, 생산
개요
Arbekacin is a semi-synthetic derivative of dibekacin useful in the treatment of bacterial infections. This aminoglycoside is active against a broad spectrum of bacteria, including some of the gentamycin-, kanamycin-, and tobramycin-resistant pathogens. Compared to amikacin and dibekacin, ototoxicity is reportedly milder.정의
ChEBI: A kanamycin that is kanamycin B bearing an N-(2S)-4-amino-2-hydroxybutyryl group on the aminocyclitol ring.Antimicrobial activity
The 1-N-(4-amino-2-hydroxybutyryl) derivative of dibekacin, to which it bears the same relation as amikacin bears to kanamycin A. Supplied as the sulfate.Activity and stability to aminoglycoside-modifying enzymes are comparable with those of amikacin. It is active against many strains of methicillin-resistant Staph. aureus, either alone or in combination with β-lactam or other agents. Synergy with ampicillin has been observed for high-level gentamicin- and vancomycin-resistant enterococci.
A 3 mg/kg intravenous dose achieved a peak concentration of c. 8 mg/L after 1 h. The plasma half-life is about 2 h and protein binding 3–12%.
About 85% of the dose can be recovered from urine over 48 h. It is retained in renal failure, but moderately well removed by hemodialysis with a plasma half-life of 2–4 h. Peak concentrations of 10.9 mg/L and trough concentrations of 1.7 mg/L have been reported in patients treated for MRSA infection where Cmax:MIC ratios of >25 and AUC:MIC ratios of >186 were associated with improved cure rates, and both Cmin and AUC were associated with the incidence of nephrotoxicity.
Toxicity and side effects are typical of the aminoglycoside class. It is used in severe infection cause by susceptible microorganisms, but is not widely available.
Arbekacin 준비 용품 및 원자재
원자재
N-히드록시석신이미드
암모니아수
트리플루오로아세트 산
1-Methylpyrazole-4-ethoxycarbonyl-5-ethoxycarbonylsulfonamide
1,1-디메톡시에탄
Bekanamycin
암모니아(가스)
아세트산(빙초산)
벤질 클로로탄소산
수소
Palladium hydroxide
하이드록시부티르산
준비 용품
Arbekacin 공급 업체
글로벌( 52)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49391 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29825 | 58 |
SIMAGCHEM CORP | +86-13806087780 |
sale@simagchem.com | China | 17367 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 |
1026@dideu.com | China | 8853 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 |
info@afinechem.com | China | 15395 | 58 |
LUYUNJIA CHEMISTRY XIAMEN LIMITED | +86-592-5360779 +86-13055435203 |
China | 5996 | 58 | |
GIHI CHEMICALS CO.,LIMITED | +8618058761490 |
info@gihichemicals.com | China | 50000 | 58 |
Hebei Miaoyin Technology Co.,Ltd | +86-17367732028 +86-17367732028 |
kathy@hbyinsheng.com | China | 3582 | 58 |