트리플루오로아세트 산
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트리플루오로아세트 산 속성
- 녹는점
- -15.4 °C (lit.)
- 끓는 점
- 72.4 °C (lit.)
- 밀도
- 1.489 g/mL at 20 °C (lit.)
- 증기 밀도
- 3.9 (vs air)
- 증기압
- 97.5 mm Hg ( 20 °C)
- 굴절률
- n
20/D 1.3(lit.)
- 인화점
- None
- 저장 조건
- Store at +15°C to +25°C.
- 용해도
- 에테르, 아세톤, 에탄올, 벤젠, 헥산 및 CCl44와 혼합 가능합니다.
- 산도 계수 (pKa)
- -0.3(at 25℃)
- 물리적 상태
- 액체
- Specific Gravity
- 1.480
- 색상
- 무색의
- 수소이온지수(pH)
- 1 (10g/l, H2O)
- pH 범위
- 1
- 냄새
- 날카롭고 자극적인 냄새
- 수용성
- 혼용 가능
- 감도
- Hygroscopic
- 최대 파장(λmax)
- λ: 260 nm Amax: 0.9
λ: 270 nm Amax: 0.10
λ: 280 nm Amax: 0.05
λ: 290 nm Amax: 0.04
λ: 300 nm Amax: 0.03
λ: 320 nm Amax: 0.025
- Merck
- 14,9681
- BRN
- 742035
- Dielectric constant
- 23.7（20℃）
- 안정성
- 안정적인. 가연성 물질, 강염기, 물, 강산화제와 혼합할 수 없습니다. 불연성. 흡습성. 염기와 격렬하게 반응할 수 있음.
- InChIKey
- DTQVDTLACAAQTR-UHFFFAOYSA-N
- CAS 데이터베이스
- 76-05-1(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | C,T,Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 20-35-52/53-34 | ||
| 안전지침서 | 9-26-27-28-45-61-28A-36/37/39 | ||
| 유엔번호(UN No.) | UN 2699 8/PG 1 | ||
| WGK 독일 | 2 | ||
| RTECS 번호 | AJ9625000 | ||
| F 고인화성물질 | 3 | ||
| 위험 참고 사항 | Toxic/Corrosive | ||
| TSCA | T | ||
| 위험 등급 | 8 | ||
| 포장분류 | I | ||
| HS 번호 | 29159080 | ||
| 유해 물질 데이터 | 76-05-1(Hazardous Substances Data) | ||
| 독성 | LD50 i.v. in mice: 1200 mg/kg (Airaksinen, Tammisto) | ||
| 기존화학 물질 | KE-34233 |
트리플루오로아세트 산 C화학적 특성, 용도, 생산
화학적 성질
Trifluoroacetic acid (TFA) is an analogue of acetic acid with the three hydrogen atoms replaced by three fluorine atoms. It has a vinegar-like odor and is a strong acid, a good solvent and has excellent reactive properties. The specific gravity of liquid TFA is 1.48 and it boils at 72 °C. Trifluoroacetic Acid is a solvent that is used in the production of pharmaceutical and agricultural chemicals as well as in many other specialized applications. Some of the more popular uses for TFA are as a silyl catalyst when derivatizing carbohydrates, as a reagent for purifying large peptides, as an ion pair reagent, and as an LC mobile phase additive.용도
Trifluoroacetic acid is an important building block in the synthesis of pharmaceuticals, agrochemicals and performance products. It is a precursor to many fluorinated compounds, and widely used in peptide synthesis and other organic transformations involving deprotection of t-BOC group. The combination of properties like solubility in most of the solvents, volatility, catalytic property, and strong acidity with non-oxidizing nature makes it a widely used reagent in organic synthesis. Trifluoroacetic acid can use as an ion pairing agent in liquid chromatography, as a solvent in NMR spectroscopy and as a calibrant in mass spectrometry. It is used as a catalyst in esterification reaction and condensation reaction and a protective agent for hydroxyl and amino.정의
ChEBI: Trifluoroacetic acid is a monocarboxylic acid that is the trifluoro derivative of acetic acid. It has a role as a reagent and a human xenobiotic metabolite. It derives from an acetic acid. It is a conjugate acid of a trifluoroacetate.일반 설명
Trifluoroacetic acid appears as a colorless fuming liquid with a pungent odor. Soluble in water and denser than water. Corrosive to skin, eyes and mucous membranes. Used to make other chemicals and as a solvent.공기와 물의 반응
Fumes in air. Soluble in water.반응 프로필
Trifluoroacetic acid is a strong acid; attacks many metals [Handling Chemicals Safely 1980. p. 935]. A 30% solution of hydrogen peroxide in Trifluoroacetic acid is often used to destructively oxidize aromatic rings in preference to the side chains. Explosions have occurred, if the excess peroxide is not catalytically destroyed, prior to removal of solvent, [Tetrahedron Lett., 1977, 1703-1704]. The reduction of amides of Trifluoroacetic acid with lithium aluminum hydride are dangerous at all phases of the process, explosions have occurred, [Chem. Eng. News, 1955, 33, 1368].건강위험
Trifluoroacetic acid is a highly corrosive substance. Contact of the liquid with the skin, eyes, and mucous membranes can cause severe burns, and ingestion can result in serious damage to the digestive tract. TFA vapor is highly irritating of the eyes and respiratory tract, and inhalation of high concentrations can lead to severe destruction of the upper respiratory tract and may be fatal as a result of pulmonary edema. Symptoms of overexposure to TFA vapor include a burning feeling, coughing, headache, nausea, and vomiting.Trifluoroacetic acid has not been found to be carcinogenic or to show reproductive or developmental toxicity in humans.
화재위험
Trifluoroacetic acid is not combustible. Nevertheless, the presence of trifluoroacetic acid at the site of a fire would be of great concern because of its high vapor pressure and extreme corrosiveness. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.Safety Profile
Poison by ingestion and intraperitoneal routes. Moderately toxic by intravenous route. Mildly toxic by inhalation. A corrosive irritant to skin, eyes, and mucous membranes. When heated to decomposition it emits toxic fumes of F-. Used as a strong organic acid catalyst.저장
trifluoroacetic acid should be stored in an acid cabinet away from other classes of compounds. Because of its high vapor pressure, fumes of trifluoroacetic acid can destroy labels on other bottles if the container is not tightly sealed.Purification Methods
The purification of trifluoroacetic acid, reported in earlier editions of this work, by refluxing over KMnO4 for 24hours and slowly distilling has resulted in very SERIOUS EXPLOSIONS on various occasions, but not always. This apparently depends on the source and/or age of the acid. The method is NOT RECOMMENDED. Water can be removed by adding trifluoroacetic anhydride (0.05%, to diminish water content) and distilling. [Conway & Novak J Phys Chem 81 1459 1977]. It can be refluxed and distilled from P2O5. It is further purified by fractional crystallisation by partial freezing and again distilled. Highly TOXIC vapour. Work in an efficient fume hood. [Beilstein 2 IV 458.]비 호환성
Mixing trifluoroacetic acid and water evolves considerable heat.폐기물 처리
Trifluoroacetic acid and waste material containing this substance should be placed in an appropriate container, clearly labeled, and handled according to your institution's waste disposal guidelines.트리플루오로아세트 산 준비 용품 및 원자재
원자재
준비 용품
Methyl trifluoroacetate
Quinapril
4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE
5-AMINO-6-CHLORO-PYRIMIDIN-4-OL
5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE
Octreotide acetate
2-(4-플루오로벤조일)-1-벤조푸란-5-카르발데하이드
Isepamicine
Cefcapene pivoxil
PYRIDIN-3-YLMETHYL-HYDRAZINE
1H-피롤로[2,3-b]피리딘,4-니트로-,7-옥사이드
2-(4-PENTYLBENZOYL)-1-BENZOFURAN-5-CARBALDEHYDE
2-(4-클로로벤조일)-1-벤조푸란-5-카르발데하이드
1-TERT-부틸-5-(트리플루오로메틸)-1H-피라졸
4-CHLORO-6-HYDRAZINO-PYRIMIDIN-5-YLAMINE
2-(4-브로모벤졸)-1-벤조푸란-5-카발데하이드
Cefteram pivoxil
Lisinopril
라자베미데
Ziprasidone
세프부페라존
프라바스타틴
1-TERT-BUTYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE
피리딘-4-일메틸-히드라진
세프티부텐
4-하이드록시-2-(트리플루오로로메틸)퀴놀린
Arbekacin
2,4,6-Trichloropyridine
1,7-디데아자아데닌
4-브로모-2-(트리플루오로메틸)퀴놀린
FENPICLONIL
3-BROMO-5-(TRIFLUOROMETHYL)BENZENESULFONYL CHLORIDE
4-AMINO-2,6-DIBROMOPYRIDINE
(S)-2-Methylproline
Alacepril
LIMAPROST
1H-피롤로[2,3-B]피리딘,4-니트로-
1,2,3,9-테트라하이드로-4(H)-카르바졸-4-온
1-(3-PYRROLIDINOPROPYL)PIPERAZINE
2,2,2-TRIFLUORO-1-(3-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL)ETHANONE
트리플루오로아세트 산 공급 업체
글로벌( 761)공급 업체
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|---|---|---|---|---|---|
| CD Chemical Group Limited | +8615986615575 |
info@codchem.com | China | 20342 | 58 |
| ShanDong Look Chemical Co.,Ltd. | +8617653113219 |
sales01@sdlookchemical.com | China | 2737 | 58 |
| Shandong Zhishang New Material Co., Ltd. | +8617653113209 |
sales002@sdzschem.com | China | 3049 | 58 |
| Zouping mingyuan import & export trading co., ltd | +86-0543-2240078 +8618364991597 |
myzhao793@163.com | China | 994 | 58 |
| Shandong Dexiang International Trade Co., Ltd | +86-15662691337 +86-15662695772 |
539942812@qq.com | China | 998 | 58 |
| Yujiang Chemical (Shandong) Co.,Ltd. | +86-17736087130 +86-18633844644 |
catherine@yjchem.com.cn | China | 985 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 57505 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 52925 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5893 | 58 |
| Beijing Sunsoly S&T Co.,Ltd | +8613910445483 |
amanda@sunsoly.com | China | 297 | 58 |