NADP sodium salt
- CAS No.
- 1184-16-3
- Chemical Name:
- NADP sodium salt
- Synonyms
- TPN;NADP SODIUM SALT;β-Nicotinamide Adenine Dinuclotide Phosphate;NADP Sodium;NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE SODIUM SALT;beta-Nicotinamide adenine dinucleotide phosphate hydrate;β-Nicotinamide Adenine Dinucleotide Phosphate Sodium Salt Hydrate;β-NicotinaMide Adenine Dinucleotide Phosphate SodiuM Salt Hydrate (~90%);beta-NicotinaMide Adenine Dinucleotide Phosphate SodiuM Salt Hydrate, oxidized forM [for BiocheMical Research];TPN-NA
- CBNumber:
- CB6355458
- Molecular Formula:
- C21H29N7NaO17P3
- Molecular Weight:
- 767.41
- MOL File:
- 1184-16-3.mol
- Modify Date:
- 2024/9/20 17:27:21
| Melting point | 175-178 °C (dec.)(lit.) |
|---|---|
| storage temp. | -20°C |
| solubility | H2O: 50 mg/mL |
| form | powder |
| color | off-white to yellow |
| PH | 2.0-4.0 |
| Water Solubility | Soluble in water. |
| Merck | 14,6344 |
| BRN | 4779954 |
| InChI | InChI=1/C21H28N7O17P3.Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32;/h1-4,7-8,10-11,13-16,20-21,29-31H,5-6H2,(H7-,22,23,24,25,32,33,34,35,36,37,38,39);/q;+1/p-1/t10-,11-,13-,14-,15-,16-,20-,21-;/s3 |
| InChIKey | JNUMDLCHLVUHFS-QYZPTAICSA-M |
| SMILES | [C@H]1(O[C@H](COP([O-])(=O)OP([O-])(=O)OC[C@@H]2[C@@H](O)[C@@H](O)[C@H]([N+]3C=CC=C(C(=O)N)C=3)O2)[C@@H](O)[C@H]1OP(=O)(O)O)N1C=NC2C(N)=NC=NC1=2.[Na+] |&1:0,2,14,15,17,19,30,32,r| |
SAFETY
Risk and Safety Statements
| Hazard Codes | Xn,Xi | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Risk Statements | 36-36/37/38 | |||||||||
| Safety Statements | 22-24/25-37/39-36-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UU3440000 | |||||||||
| HS Code | 29349990 | |||||||||
| NFPA 704 |
|
NADP sodium salt price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | N8160 | β-Nicotinamide adenine dinucleotide phosphate sodium salt pkg of 10?mg (per vial) | 1184-16-3 | 15VIALS | ₹29389.88 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | N8035 | β-Nicotinamide adenine dinucleotide phosphate sodium salt pkg of 5?mg (per vial) | 1184-16-3 | 15VIALS | ₹24789.25 | 2022-06-14 | Buy |
| ALFA India | ALF-044126-MD | beta-Nicotinamide adenine dinucleotide phosphate monosodium salt | 1184-16-3 | 250mg | ₹8350 | 2022-05-26 | Buy |
| ALFA India | ALF-044126-03 | beta-Nicotinamide adenine dinucleotide phosphate monosodium salt | 1184-16-3 | 1g | ₹21935 | 2022-05-26 | Buy |
| TCI Chemicals (India) | C0379 | β-Nicotinamide Adenine Dinucleotide Phosphate Sodium Salt Hydrate, oxidized form [for Biochemical Research] | 1184-16-3 | 100MG | ₹2900 | 2022-05-26 | Buy |
NADP sodium salt Chemical Properties,Uses,Production
Description
The nicotinamide adenine dinucleotide phosphate oxidase（NADP）is a multicomponent system that transfers an electron to molecular oxygen by way of FAD and heme to form superoxide (O2?) .Cytochrome b558 is a membrane-bound heterodimer lodged in the wall of the secondary granules; the large glycosylated β subunit is gp91phox and the small nonglycosylated α subunit is p22phox.The cytoplasmic tail of gp91phox binds FAD, heme, and NADPH, which are required for electron transfer to oxygen (O2).Neutrophil stimulation leads to aggregation and phosphorylation of p47phox, p67phox, p40phox, and the small guanosine triphosphate (GTP)–binding proteins RAC1/RAC2, which dock with the cytochrome at the membrane through binding of p47phox and p22phox.
Description
Nicotinamide adenine dinucleotide phosphate, abbreviated NADP+ or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as the Calvin cycle and lipid and nucleic acid syntheses, which require NADPH as a reducing agent ('hydrogen source').It is used by all forms of cellular life.
Chemical Properties
White to slightly yellowish powder
Uses
β-Nicotinamide adenine dinucleotide 2′-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2′-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) involved in a wide range of enzyme catalyzed oxidation reduction reactions.
β-Nicotinamide Adenine Dinucleotide Phosphate Sodium Salt Hydrate is a substrate NADP which plays a role in a variety of metabolic processes.
Biosynthesis
In general, NADP+ is synthesized before NADPH is. Such a reaction usually starts with NAD+ from either the de-novo or the salvage pathway, with NAD+ kinase adding the extra phosphate group. ADP-ribosyl cyclase allows for synthesis from nicotinamide in the salvage pathway, and NADP+ phosphatase can convert NADPH back to NADH to maintain a balance.Some forms of the NAD+ kinase, notably the one in mitochondria, can also accept NADH to turn it directly into NADPH.[3][4] The prokaryotic pathway is less well understood, but with all the similar proteins the process should work in a similar way.
Biochem/physiol Actions
Electron acceptor
Mechanism of action
NADP sodium salt exerts its effect by competitively inhibiting nucleotide metabolism through the suppression of enzymes like nucleoside diphosphate kinase (NDPK) and adenosine kinase (ADK). Additionally, it serves as a substrate for enzymes like DNA polymerases and RNA polymerases, enabling the integration of NADP monosodium salt into nucleic acids during replication and transcription.
NADP sodium salt Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| Anand Agencies | 91-20-24454597 | Maharashtra, India | 2337 | 58 | Inquiry |
| Sisco Resech Laboratories Private Limited | +91-22-4268 5800 | Mumbai, India | 655 | 58 | Inquiry |
| Maas Pharma Chemicals | +91-9958666224 | Delhi, India | 1607 | 58 | Inquiry |
| Reax Chemicals | 08048372701Ext 416 | Hyderabad, India | 4223 | 58 | Inquiry |
| Spectrochem Private Limited | 08048372608Ext 246 | Maharashtra, India | 1056 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Central Drug House(P) Ltd. | 91-11-49404040 | New Delhi, India | 6160 | 58 | Inquiry |
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