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DSIP

DSIP Structure
CAS No.
62568-57-4
Chemical Name:
DSIP
Synonyms
DSIP;WAGGDASGE;DSIP 4H2O;EMIDELTIDE;Delta-Sleep;DSIP acetate;Etipolypeptide;DSIP USP/EP/BP;Ftpp/Adipotide;DSIP nonapeptide
CBNumber:
CB6478191
Molecular Formula:
C35H48N10O15
Molecular Weight:
848.82
MOL File:
62568-57-4.mol
Modify Date:
2024/7/25 20:04:51

DSIP Properties

Boiling point 1522.7±65.0 °C(Predicted)
Density 1.458±0.06 g/cm3(Predicted)
storage temp. −20°C
form Powder
pka 3.18±0.10(Predicted)
color White to off-white
Water Solubility Soluble in water at 0.5mg/ml
Sequence H-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH
InChIKey ZRZROXNBKJAOKB-GFVHOAGBSA-N

SAFETY

Risk and Safety Statements

Safety Statements  22-24/25
WGK Germany  3

DSIP price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) D4072 Delta Sleep Inducing Peptide 62568-57-4 5MG ₹12632.78 2022-06-14 Buy
Sigma-Aldrich(India) D4072 Delta Sleep Inducing Peptide 62568-57-4 25MG ₹50769.25 2022-06-14 Buy
Product number Packaging Price Buy
D4072 5MG ₹12632.78 Buy
D4072 25MG ₹50769.25 Buy

DSIP Chemical Properties,Uses,Production

Description

Delta-sleep-inducing peptide (DSIP) is a neuropeptide with amino acid sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu and molecular mass 848.81 g/mol. DSIP occurs in both free and bound forms in the hypothalamus, limbic system and pituitary as well as various peripheral organs, tissues and body fluids. In the pituitary it co-localises with many peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH) and melanin concentrating hormone (MCH). Delta-sleep-inducing peptide is abundant in the gut secretory cells and in the pancreas where it co-localises with glucagon.

Uses

Delta-sleep-inducing peptide (DSIP) was isolated, characterized, and synthesized more than 6 years ago. It can help relieve stress and aches that keep you from restful sleep. It was first proposed as a sleep-peptide and this remains the prevalent impression of its function. DSIP is a natural sleep-promoting nonapeptide with a few beneficial functions. The peptide has been used to treat poor sleep, pain conditions, stress-related symptoms, and more. Delta-Sleep Inducing Peptide trifluoroacetate salt H-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH trifluoroacetate salt is a useful research chemical compound.

Uses

DSIP is thought to increase sleep regulation, reduce motor activity to improve deep sleep, stimulate ACTH and LH levels, and reportedly normalize blood pressure. DSIP can change the serum level of some hormones, such as adrenocorticotropic hormone, somatostatin, serotonin, etc.

Definition

Emideltide or DSIP is a nonapeptide that is found in neurons, peripheral organs, and plasma. This neuropeptide induces mainly delta sleep in mammals. In addition to sleep, the peptide has been observed to affect electrophysiological activity, neurotransmitter levels in the brain, circadian and locomotor patterns, hormonal levels, psychological performance, and the activity of neuropharmacological drugs including their withdrawal.

benefits

Can restore disturbed sleep patterns;Can promote LH and GH release;Can reduce persistent/chronic pain;Can modulate cortisol production.

benefits

Delta sleep-inducing peptide (DSIP), which suppresses excess production of free radicals in the CNS and prevents neuron death during the body’s response to stress. DSIP activates oxidative phosphorylation and increases the resistance of brain neurons to hypoxia in vitro. It decreases the sensitivity of neuron receptors to the excitatory actions of glutamate. Thus, DSIP helps to prevent excitotoxicity, which may underlie its neuroprotective action in cerebral ischemia[1].

References

[1] E. Koplik. “Delta sleep-inducing peptide and Deltaran: Potential approaches to antistress protection.” Neuroscience and Behavioral Physiology 38 1 (2008): 953–957.

DSIP Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 252)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
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Related Qustion

SLEEP INDUCING PEPTIDE WAGGDASGE TRP-ALA-GLY-GLY-ASN-ALA-SER-GLY-GLU TRP-ALA-GLY-GLY-ASP-ALA-SER-GLY-GLU TRP-ALA-GLY-GLY-ASP-ALA-SER-GLY-GLU 4H2O DELTA SLEEP INDUCING PEPTIDE DELTA SLEEP-INDUCING PEPTIDE 4H2O DSIP DSIP 4H2O H-TRP-ALA-GLY-GLY-ASP-ALA-SER-GLY-GLU-OH EMIDELTIDE TRP-ALA---ASP-ALA-SER--GLU(TRP-ALA-GLY-GLY-ASP-ALA-SER-GLY-GLU) DSIP, Sleep inducing peptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu L-Trp-L-Ala-Gly-Gly-L-Asp-L-Ala-L-Ser-Gly-Glu-OH L-Trp-L-Ala-Gly-Gly-L-Asp-L-Ala-L-Ser-Gly-L-Glu-OH Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH TRP-ALA-GLY-GLY-ASP-ALA-SER: PO3H2-GLY-GLU [WAGGDA-S: PO3H2-GE] DSIP nonapeptide L-Tryptophyl-L-alanylglycylglycyl-L-alpha-aspartyl-L-alanyl-L-serylglycyl-L-glutamic acid DSIP, EMideltide Delta sleep inducing peptide, ≥97% (HPLC) DSIP/Delta Sleep Inducing Peptide Deltasleep-inducing peptide (rabbit) Delta-Sleep Inducing Peptide trifluoroacetate salt H-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH trifluoroacetate salt Etipolypeptide DSIP USP/EP/BP Ftpp/Adipotide DSIP acetate Emideltide (δ-Sleep Inducing Peptide) Delta-Sleep DSIP Lyophilized Powder Delta Sleep Inducing Peptide Acetate δ-Sleep Inducing Peptide acetate 62568-57-4 9431-45-4 C35H48N10O15 Peptide 62568-57-4