ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Elamipretide

Elamipretide

CAS No.: 736992-21-5

Chemical Name:: Elamipretide

Synonyms: MTP-131;Centanafadine;SS-31, Elamipretide;Elamipretide acetate;RX-31;SS-31);Bendavia);Elamipretide;ELAMIPRETIDE, >99%;Elamipretide (SS-31

CBNumber:: CB92708860

Molecular Formula:: C32H49N9O5

Molecular Weight:: 639.79

MOL File:: 736992-21-5.mol

Modify Date:: 2024/7/25 20:04:51

Request For Quotation

Elamipretide Properties

Density	1.34±0.1 g/cm3(Predicted)
solubility	Methanol (Slightly), Water (Slightly)
pka	10.10±0.25(Predicted)
form	Solid
color	White to Off-White
Sequence	H-d-Arg-dimethylTyr-Lys-Phe-NH2
Stability	Hygroscopic
InChIKey	SFVLTCAESLKEHH-WKAQUBQDSA-N
SMILES	C(N)(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC1=C(C)C=C(O)C=C1C)NC(=O)[C@@H](CCCNC(N)=N)N

Elamipretide Chemical Properties,Uses,Production

Description

Elamipretide, also known as MTP 131, is a mitochondria-targeted peptide antioxidant. Elamipretide decreases inflammation and protect against a variety of neurological illnesses. Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice. Elamipretide Promotes Mitophagosome Formation and Prevents Its Reduction Induced by Nutrient Excess in INS1 β-cells.

Mechanism of action

Elamipretide can inhibit the production of pathogenic ROS (reactive oxygen species) and restore mitochondrial ATP synthesis. Currently, the most accepted mechanism for these two actions is the direct interaction between Elamipretide and cardiolipin.

Clinical Use

Barth syndrome is an ultra-rare genetic condition characterized by cardiac abnormalities leading to exercise intolerance, muscle weakness, debilitating fatigue, heart failure, recurrent infections, and delayed growth. There are currently no FDA- or EMA-approved therapies for patients with Barth syndrome. Elamipretide has an Orphan Drug, Fast Track and Rare Pediatric Designation from the FDA and Orphan Drug Designation from the EMA for treating Barth syndrome.

Side effects

Side effects of elamipretide include:
Mild redness or itching at the injection site
Headache
Dizziness

Elamipretide Preparation Products And Raw materials

Raw materials

Preparation Products

Elamipretide Suppliers

Global( 118)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Apeloa production Co.,Limited	+8619933239880	China	853	58	Inquiry
Zhejiang Hangyu API Co., Ltd	+8617531972939	China	2944	58	Inquiry
Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618740459177	China	1142	58	Inquiry
Qingdao Xinli Technology Development Co., Ltd.	+8616632313095	China	135	58	Inquiry
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD	+8615383190639	China	327	58	Inquiry
Dorne Chemical Technology co. LTD	+86-86-13583358881 +8618560316533	China	3146	58	Inquiry
Hebei Yime New Material Technology Co., Ltd.	+86-66697723 +86-17703311139	China	563	58	Inquiry
Shanghai Yunao International Trade Co., Ltd	+8617621705551	China	265	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
Apeloa production Co.,Limited	58
Zhejiang Hangyu API Co., Ltd	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	58
Qingdao Xinli Technology Development Co., Ltd.	58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD	58
Dorne Chemical Technology co. LTD	58
Hebei Yime New Material Technology Co., Ltd.	58
Shanghai Yunao International Trade Co., Ltd	58

What is Elamipretide used for?
Elamipretide is an aromatic-cationic tetrapeptide that readily penetrates cell membranes and transiently localizes to the inne....
May 7，2022

736992-21-5(Elamipretide)Related Search:

Hexapeptide-11 L-Cysteine, L-cysteinylglycyl-L-glutaminyl-L-arginyl-L-α-glutamyl-L-threonyl-L-prolyl-L-α-glutamylglycyl-L-alanyl-L-α-glutamyl-L-alanyl-L-lysyl-L-prolyl-L-tryptophyl-L-tyrosyl-, cyclic (1→17)-disulfide DERMASEPTIN PHYLLOMEDUSA SAUVAGII Vantas Eptifibatide Acetate

DSIP Ipamorelin 2'-Deoxyadenosine Bithionol Octamethylcyclotetrasiloxane

chevron_left

1of2

chevron_right

D-Arginyl-2,6-diMethyl-L-tyrosyl-L-lysyl-L-phenylalaninaMide L-Phenylalaninamide, D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl- Elamipretide Elamipretide (TFA salt) SS-31;MTP-131;BENDAVIA Bendavia) Elamipretide (SS-31 ELAMIPRETIDE, >99% Elamipretide,MTP-131,RX-31,SS-31, >99% Elamipretide (MTP-131 ELAMIPRETIDE (MTP-131;RX-31;SS-31) RX-31 SS-31) Elamipretide (SS-31) acetate (S)-6-Amino-N-((S)-1-amino-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-((R)-2-amino-5-guanidinopentanamido)-3-(4-hydroxy-2,6-dimethylphenyl)propanamido)hexanamide Elamipretide（HY-P0125 Centanafadine MTP-131 SS-31, Elamipretide Elamipretide acetate Elamipretide、SS-31、H2N-D-Arg-Dmt-Lys-Phe-NH2 736992-21-5 736992-21-5