3,4,5-Trifluorophenylboronic acid
- CAS No.
- 143418-49-9
- Chemical Name:
- 3,4,5-Trifluorophenylboronic acid
- Synonyms
- AKOS BRN-0138;3,4,5-Trifluoropheny;3,4,5-trifluoroborate;5-Trifluorophenylboronic acid;3,4,5-three fluorophenyl borate;3,4,5-Trifluophenylboronic acid;3,4,5-TRIFLUOROPHENYLBORONIC ACID;3,4,5-TRIFLUOROBENZENEBORONIC ACID;3,4,5-Trifluorophenylboronic Aicd;3,4,5-Trifluorobenzeneboronicacid97%
- CBNumber:
- CB6481302
- Molecular Formula:
- C6H4BF3O2
- Molecular Weight:
- 175.9
- MOL File:
- 143418-49-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/19 17:35:41
| Melting point | 290-295 °C (lit.) |
|---|---|
| Boiling point | 263.6±50.0 °C(Predicted) |
| Density | 1,087g/cm |
| refractive index | 1,423-1,425 |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | 18.43g/l |
| pka | 6.54±0.11(Predicted) |
| form | Powder |
| color | Tan |
| BRN | 7371914 |
| InChIKey | UHDDEIOYXFXNNJ-UHFFFAOYSA-N |
| CAS DataBase Reference | 143418-49-9(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H319-H411 | |||||||||
| Precautionary statements | P273-P301+P312+P330-P305+P351+P338 | |||||||||
| Hazard Codes | N-Xn,Xi | |||||||||
| Risk Statements | 51/53-36-22-36/37/38 | |||||||||
| Safety Statements | 61-26-37/39-36 | |||||||||
| RIDADR | 3077 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29163990 | |||||||||
| NFPA 704 |
|
3,4,5-Trifluorophenylboronic acid price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 524700 | 3,4,5-Trifluorophenylboronic acid ≥95% | 143418-49-9 | 1G | ₹11626.05 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 524700 | 3,4,5-Trifluorophenylboronic acid ≥95% | 143418-49-9 | 5G | ₹43613.93 | 2022-06-14 | Buy |
3,4,5-Trifluorophenylboronic acid Chemical Properties,Uses,Production
Description
3,4,5-Trifluorophenylboronic acid is an arylboronic acid compound used in organic synthesis and as a reaction reagent. It can be used as a catalyst to catalyse the direct amidation of amino acid derivatives and the direct polycondensation of carboxylic acids and amines; it can also be used in the formation of new 1:1 co-crystals with urea C6H4BF3O2-CH4N2O components.
Chemical Properties
Tan powder
Uses
Intermediates of Liquid Crystals
Synthesis
Add 42mmol (10.08g) of magnesium chips into a 1000mL four-necked flask, add 2 pieces of iodine, and then add 200mL of anhydrous 2-methyltetrahydrofuran, heat the temperature to 50°C, and then slowly let it cool down to 40°C. And then drip 4-5mL of 3,4,5-trifluorobromobenzene 84.4g (0.4mol) and 50mL 2-methyltetrahydrofuran mixed solution, trigger the Grignard reaction, the temperature will rise rapidly after the reaction is initiated, use The temperature is lowered to 10-15°C in an ice-water bath, and a mixture (1) composed of 3,4,5-trifluorobromobenzene 84.4g (0.4mol) and 50mL 2-methyltetrahydrofuran (1), trimethyl borate is added dropwise. A mixture of 44 grams (0.42 mol) of ester and 50 mL of 2-methyltetrahydrofuran (2).The speed of the mixed solution (1) and the mixed solution (2) is kept the same, the dropping speed is controlled, and the dropping temperature is kept at 10-15°C . After the dropping is completed, the reaction is continued at room temperature for 8 hours.After the reaction is over, the reaction solution is slowly poured into dilute hydrochloric acid, and after the addition is complete, stir for 0.5-1.5h, separate the liquids, and then extract the aqueous phase twice, combine the organic phases, dry with anhydrous sodium sulfate, spin dry, and Recrystallization of ethyl chloride gave 3,4,5-Trifluorophenylboronic acid with a yield of 78% and a content of 99.6%.
3,4,5-Trifluorophenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Shandong Promise New Material Co.,Ltd. | +86-18678104048 +86-15305334460 | China | 89 | 58 | Inquiry |
| Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 | China | 5873 | 58 | Inquiry |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | China | 5867 | 58 | Inquiry |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | China | 20294 | 58 | Inquiry |
| Springchem New Material Technology Co.,Limited | +86-021-62885108 +8613917661608 | China | 2068 | 57 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | China | 18646 | 58 | Inquiry |
| China Synchem Technology Co.,Ltd. | +86-0552-4929304 +86-18055277008 | China | 57 | 55 | Inquiry |
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