APHIDICOLIN
- CAS No.
- 38966-21-1
- Chemical Name:
- APHIDICOLIN
- Synonyms
- APC;ici69653;nsc-234714;APHIDICOLIN;(+)-APHIDICOLIN;,11a-beta,11b-beta))-;APHIDICOLIN USP/EP/BP;Aphidicolin, Ready Made Solution;(+)-APHIDICOLIN, NIGROSPORA ORYZAE;Aphidicolin, froM Nigrospora oryzae
- CBNumber:
- CB6683304
- Molecular Formula:
- C20H34O4
- Molecular Weight:
- 338.48
- MOL File:
- 38966-21-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 218-220°C |
|---|---|
| alpha | D27 +12° (c = 1 in methanol) |
| Boiling point | 394.61°C (rough estimate) |
| Density | 1.0057 (rough estimate) |
| vapor pressure | 0.55 hPa ( 20 °C) |
| refractive index | 1.4434 (estimate) |
| Flash point | 87℃ |
| storage temp. | 2-8°C |
| solubility | ethanol: soluble1mg/mL (stable at least a week at 4°C.) |
| form | White solid |
| pka | 14.24±0.70(Predicted) |
| color | colorless |
| optical activity | [α]27/D +12°, c = 1 in methanol(lit.) |
| Water Solubility | Soluble in DMSO or methanol. Insoluble in water. Store solutions at -20° |
| Merck | 13,734 |
| BRN | 4689958 |
| Stability | Stable for 2 years from date of purchase from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P271-P280 | |||||||||
| Safety Statements | 22-24 | |||||||||
| RIDADR | NA 1993 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | PB9185000 | |||||||||
| F | 10-21 | |||||||||
| HS Code | 29419090 | |||||||||
| NFPA 704 |
|
APHIDICOLIN price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A0781 | Aphidicolin from Nigrospora sphaerica ≥98% (HPLC), powder | 38966-21-1 | 1MG | ₹16064.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A0781 | Aphidicolin from Nigrospora sphaerica ≥98% (HPLC), powder | 38966-21-1 | 5MG | ₹59115.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A4487 | Aphidicolin, Ready Made Solution from Nigrospora sphaerica | 38966-21-1 | 1ML | ₹15534.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A0781 | Aphidicolin from Nigrospora sphaerica ≥98% (HPLC), powder | 38966-21-1 | 10MG | ₹109592.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 89458 | Aphidicolin analytical standard | 38966-21-1 | 5MG | ₹84121.08 | 2022-06-14 | Buy |
APHIDICOLIN Chemical Properties,Uses,Production
Description
(+)-
Chemical Properties
White crystal
Uses
(+)-Aphidicolin is a naturally occurring tetracyclic diterpene with potential antiviral and antimitotical properties.
Definition
ChEBI: A tetracyclic diterpenoid that has an tetradecahydro-8,11a-methanocyclohepta[a]naphthalene skeleton with two hydroxymethyl substituents at positions 4 and 9, two methyl substituents at positions 4 and 11b and two hydroxy substituents at positi ns 3 and 9. An antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication.
General Description
A cell-permeable tetracyclic diterpene antibiotic. Cell synchronization agent. Blocks the cell cycle at the early S-phase. Specific inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses of animal origin. Potentiates apoptosis induced by arabinosyl nucleosides in leukemia cell lines. Also induces apoptosis in HeLaS3 cells, but inhibits vincristine-induced apoptosis in the p53-negative human prostate cancer cell line PC-3.
APHIDICOLIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Merck Ltd | +91-2262109800 +91-2262109000 | Maharashtra, India | 272 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49392 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29825 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | China | 8744 | 58 | Inquiry |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | China | 15395 | 58 | Inquiry |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | China | 52861 | 58 | Inquiry |
| Alfa Chemistry | United States | 24072 | 58 | Inquiry | |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | China | 50000 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Merck Ltd | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| CONIER CHEM AND PHARMA LIMITED | 58 |
| career henan chemical co | 58 |
| TargetMol Chemicals Inc. | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 58 |
| AFINE CHEMICALS LIMITED | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 58 |
| Alfa Chemistry | 58 |
| GIHI CHEMICALS CO.,LIMITED | 58 |
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