APHIDICOLIN manufacturers and suppliers in india

APHIDICOLIN

Properties

Melting point:: 218-220°C

alpha: D27 +12° (c = 1 in methanol)

Boiling point:: 394.61°C (rough estimate)

Density: 1.0057 (rough estimate)

vapor pressure: 0.55 hPa ( 20 °C)

refractive index: 1.4434 (estimate)

Flash point:: 87℃

storage temp.: 2-8°C

solubility: ethanol: soluble1mg/mL (stable at least a week at 4°C.)

form: White solid

pka: 14.24±0.70(Predicted)

color: colorless

optical activity: [α]27/D +12°, c = 1 in methanol(lit.)

Water Solubility: Soluble in DMSO or methanol. Insoluble in water. Store solutions at -20°

Merck: 13,734

BRN: 4689958

Stability:: Stable for 2 years from date of purchase from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H315-H319-H335

Precautionary statements: P271-P280

Safety Statements: 22-24

RIDADR: NA 1993 / PGIII

WGK Germany: 3

RTECS: PB9185000

F: 10-21

HS Code: 29419090

Use

Aphidicolin is a tetracyclic diterpene antibiotic isolated from fungi, notably Cephalosporium, Nigrospora, Harziella and Phoma. Aphidicolin has antibiotic, antiviral and antimitotic properties, blocking the cell cycle at early S-phase. This property has been used to synchronise cell division and is useful as a tool in cell differentiation research. Aphidicolin is a reversible inhibitor of DNA replication by inhibiting selected DNA polymerases. Aphidicolin induces apoptosis, prolongs the half-life of DNA methyltransferase, is active against Leishmania parasites and acts synergistically with the antitumor agents, vincristine and doxorubicin.