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ChemicalBook > Product Catalog >API >Synthetic Anti-infective Drugs >Natural source of Anti-infectives >14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE

14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE

14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE Structure
CAS No.
42895-58-9
Chemical Name:
14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE
Synonyms
AP 10;14-dehydro Andrographolide;Andrographolide Impurity 1;14-deoxy11,12 deoxyandrographolide;14-Deoxy-11,12-didehydroandrographol;14-Deoxy-11,14-didehydroandrographolide;11,12-Didehydro-14-deoxyandrographolide;14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE;Deoxy-11,12-Didehydroandrographolide, 14-;14 - deoxy11,12-12 dehydroandrographolide
CBNumber:
CB6735337
Molecular Formula:
C20H28O4
Molecular Weight:
332.43
MOL File:
42895-58-9.mol
Modify Date:
2024/7/2 8:55:14
Request For Quotation

14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE Properties

Melting point 204-205℃
Boiling point 519.6±50.0 °C(Predicted)
Density 1.17
storage temp. Store at -20°C
solubility DMF: 10 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 2 mg/ml
pka 14.80±0.70(Predicted)
form Solid
color White to off-white

SAFETY

Risk and Safety Statements

WGK Germany  3

14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 55549 14-Deoxy-11,12-didehydroandrographolide analytical standard 42895-58-9 5MG ₹31533.23 2022-06-14 Buy
Product number Packaging Price Buy
55549 5MG ₹31533.23 Buy

14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE Chemical Properties,Uses,Production

Description

14-deoxy-11,12-didehydro Andrographolide is an analog of the natural diterpenoid andrographolide that can be isolated from A. paniculata. It retains the anti-inflammatory, antiallergenic, immuno-stimulatory, antiviral, antioxidant, hepatoprotective, and cardiovascular activities of andrographolide without producing cytotoxicity in KB cells (ED50 >20 μg/ml) that can occur with andrographolide 6.5 μg/ml.

Uses

14-Deoxy-11,12-didehydroandrographolide is the derivative of Andrographolide(A637475) is a labdane diterpenoid (2). Andrographolide is the main bioactive component isolated from the medicinal plant Andrographis paniculata (2). Andrographolide showed significant antihepatotoxic action in P. berghei K173-induced hepatic damage in M. natalensis(1). Andrographolide inhibits tumor necrosis factor-α (TNF-α)-induced intercellular adhesion mol.-1 (ICAM-1) expression and adhesion of HL-60 cells onto human umbilical vein endothelial cells (HUVEC), which are associated with inflammatory diseases (2). These findings suggest that Andrographolide may have potential as a cardiovascular-protective agent.

14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE Preparation Products And Raw materials

Raw materials

Preparation Products

14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE Suppliers

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Shaanxi Pioneer Biotech Co., Ltd . 58
career henan chemical co 58
Hubei Ipure Biology Co., Ltd 58
Dideu Industries Group Limited 58

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14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE 3-[(1E)-2-[(1R,4aS,5R,6R,8aR)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethenyl]- 2(5H)-furanone ent-(3β,11E)-3,19-Dihydroxy-8(17),11,13-labdatrien-16,15-olide 11,12-Didehydro-14-deoxyandrographolide 14-Deoxy-11,14-didehydroandrographolide AP 10 Deoxy-11,12-Didehydroandrographolide, 14- 3-[(E)-2-[(1R,4aβ)-2-Methylene-5α-(hydroxymethyl)-5,8aα-dimethyl-6α-hydroxydecalin-1α-yl]ethenyl]-2,5-dihydrofuran-2-one 3-[(E)-2-[(1R,4aβ)-2-Methylene-5α-(hydroxymethyl)-6α-hydroxy-5,8aα-dimethyldecahydronaphthalene-1α-yl]ethenyl]-2,5-dihydrofuran-2-one 3-[(E)-2-[(1R,4aβ)-Decahydro-6α-hydroxy-5α-(hydroxymethyl)-5,8aα-dimethyl-2-methylenenaphthalen-1-yl]vinyl]furan-2(5H)-one 14-Deoxy-11,12-didehydroandrographol 14-Deoxy-11,12-didehydroandrographolide16,15-olide 3,19-Dihydroxylabda-8(17),11,13-trien-16,15-olide 3-((E)-2-((1R,4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl)vinyl)furan-2(5H)-one 14-Deoxy-11,12-didehydroandrographolide?, >98% 2(5H)-Furanone, 3-[(1E)-2-[(1R,4aS,5R,6R,8aR)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethenyl]- 14-dehydro Andrographolide 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE USP/EP/BP Andrographolide Impurity 1 4-[(E)-2-[(1R,4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethenyl]-2H-furan-5-one 14-deoxy11,12 deoxyandrographolide 14 - deoxy11,12-12 dehydroandrographolide 42895-58-9